{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:32:31Z","timestamp":1780396351589,"version":"3.54.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,2,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Insight into type 5 long QT syndrome (LQT5) has been limited to case reports and small family series. Improved understanding of the clinical phenotype and genetic features associated with rare\n              <jats:italic>KCNE1<\/jats:italic>\n              variants implicated in LQT5 was sought through an international multicenter collaboration.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Patients with either presumed autosomal dominant LQT5 (N = 229) or the recessive Type 2 Jervell and Lange-Nielsen syndrome (N = 19) were enrolled from 22 genetic arrhythmia clinics and 4 registries from 9 countries.\n              <jats:italic>KCNE1<\/jats:italic>\n              variants were evaluated for ECG penetrance (defined as QTc &gt;460 ms on presenting ECG) and genotype-phenotype segregation. Multivariable Cox regression was used to compare the associations between clinical and genetic variables with a composite primary outcome of definite arrhythmic events, including appropriate implantable cardioverter-defibrillator shocks, aborted cardiac arrest, and sudden cardiac death.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total of 32 distinct\n              <jats:italic>KCNE1<\/jats:italic>\n              rare variants were identified in 89 probands and 140 genotype positive family members with presumed LQT5 and an additional 19 Type 2 Jervell and Lange-Nielsen syndrome patients. Among presumed LQT5 patients, the mean QTc on presenting ECG was significantly longer in probands (476.9\u00b138.6 ms) compared with genotype positive family members (441.8\u00b130.9 ms,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). ECG penetrance for heterozygous genotype positive family members was 20.7% (29\/140). A definite arrhythmic event was experienced in 16.9% (15\/89) of heterozygous probands in comparison with 1.4% (2\/140) of family members (adjusted hazard ratio [HR] 11.6 [95% CI, 2.6\u201352.2];\n              <jats:italic>P<\/jats:italic>\n              =0.001). Event incidence did not differ significantly for Type 2 Jervell and Lange-Nielsen syndrome patients relative to the overall heterozygous cohort (10.5% [2\/19]; HR 1.7 [95% CI, 0.3\u201310.8],\n              <jats:italic>P<\/jats:italic>\n              =0.590). The cumulative prevalence of the 32\n              <jats:italic>KCNE1<\/jats:italic>\n              variants in the Genome Aggregation Database, which is a human database of exome and genome sequencing data from now over 140\u2009000 individuals, was 238-fold greater than the anticipated prevalence of all LQT5 combined (0.238% vs 0.001%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              The present study suggests that putative\/confirmed loss-of-function\n              <jats:italic>KCNE1<\/jats:italic>\n              variants predispose to QT prolongation, however, the low ECG penetrance observed suggests they do not manifest clinically in the majority of individuals, aligning with the mild phenotype observed for Type 2 Jervell and Lange-Nielsen syndrome patients.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.119.043114","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T10:00:19Z","timestamp":1579168819000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["An International Multicenter Evaluation of Type 5 Long QT Syndrome"],"prefix":"10.1161","volume":"141","author":[{"given":"Jason D.","family":"Roberts","sequence":"first","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada (J.D.R., I.E.H., M.D.Y., L.J.G., P.L.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Yukiko","family":"Asaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah, and Primary Children\u2019s Hospital, Salt Lake City (S.Y.A., S.P.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Istituti Clinici Scientifici Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico and Department of Molecular Medicine, University of Pavia, Italy (A.M., D.K., S.G.P.)."},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Martijn","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Tuleta","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Department of Cardiology I (I.T.), University Hospital Muenster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison R.","family":"Muir","sequence":"additional","affiliation":[{"name":"Northern Ireland Inherited Cardiac Conditions Service, Belfast City Hospital, United Kingdom (A.R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (L.C., C.S., P.J.S.)."},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Italy (L.C.)."},{"name":"Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy (L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Krahn","sequence":"additional","affiliation":[{"name":"Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada (A.D.K., T.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center, University of Rochester Medical Center, NY (V.K., W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Benjamin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Department of Molecular Pharmacology &amp; Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (M.B., J.R.G., M.J.A.)."},{"name":"Departments of Medicine (M.B.S., N.C., D.M.R.), Vanderbilt University Medical Center, Nashville, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Johnsrude","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, University of Louisville, KY (C.L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan (T.A., K.S., W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Marcondes","sequence":"additional","affiliation":[{"name":"Cardiac Inherited Disease Group New Zealand, Paediatric and Congenital Cardiac Services, Starship Children\u2019s Hospital, Auckland (L.M., J.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Baban","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Pediatric Cardiology and Cardiac Arrhythmias Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Ges\u00f9 Children\u2019s Hospital and Research Institute, Rome, Italy (A.B., F.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Udupa","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Canada (S.U., R.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brynn","family":"Dechert","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, University of Michigan Children\u2019s Hospital, University of Michigan, Ann Arbor (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fischbach","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, Sibley Heart Center Cardiology, GA (P.F., L.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Knight","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, Sibley Heart Center Cardiology, GA (P.F., L.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics (E.V.), University of California San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deni","family":"Kukavica","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Istituti Clinici Scientifici Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico and Department of Molecular Medicine, University of Pavia, Italy (A.M., D.K., S.G.P.)."},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Stallmeyer","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Institute for Genetics of Heart Disease (B.S., S.D., E.S.-B.), University Hospital Muenster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Giudicessi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Department of Molecular Pharmacology &amp; Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (M.B., J.R.G., M.J.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Spazzolini","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (L.C., C.S., P.J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Shimamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan (T.A., K.S., W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafik","family":"Tadros","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Center, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada (R.T., J., C.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Cadrin-Tourigny","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Center, Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Quebec, Canada (R.T., J., C.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J.","family":"Duff","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Canada (H.J.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Queen\u2019s University, Kingston, Ontario, Canada (C.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Roston","sequence":"additional","affiliation":[{"name":"Heart Rhythm Services, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada (A.D.K., T.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanushi D.","family":"Wijeyeratne","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St. George\u2019s University of London, and St. George\u2019s University Hospitals NHS Foundation Trust, United Kingdom (Y.D.W., E.R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"El Hajjaji","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada (J.D.R., I.E.H., M.D.Y., L.J.G., P.L.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisoon D.","family":"Yousif","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada (J.D.R., I.E.H., M.D.Y., L.J.G., P.L.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne J.","family":"Gula","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada (J.D.R., I.E.H., M.D.Y., L.J.G., P.L.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Leong-Sit","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada (J.D.R., I.E.H., M.D.Y., L.J.G., P.L.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Chavali","sequence":"additional","affiliation":[{"name":"Departments of Medicine (M.B.S., N.C., D.M.R.), Vanderbilt University Medical Center, Nashville, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Landstrom","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, and Department of Cell Biology, Duke University School of Medicine, Durham, NC (A.P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Centre, location AMC, Heart Center, Department of Clinical and Experimental Cardiology, The Netherlands (G.M.M., A.A.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Dittmann","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Institute for Genetics of Heart Disease (B.S., S.D., E.S.-B.), University Hospital Muenster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A. M.","family":"Wilde","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Amsterdam University Medical Centre, location AMC, Heart Center, Department of Clinical and Experimental Cardiology, The Netherlands (G.M.M., A.A.M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah R.","family":"Behr","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St. George\u2019s University of London, and St. George\u2019s University Hospitals NHS Foundation Trust, United Kingdom (Y.D.W., E.R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Denmark (J.T.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin M.","family":"Scheinman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Section of Cardiac Electrophysiology M.M.S.), University of California San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco V.","family":"Perez","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (M.V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Kaski","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., P.J.S., E.S.-B., S.G.P.)."},{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital and UCL Institute of Cardiovascular Science, London, United Kingdom (J.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Gow","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Canada (S.U., R.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Drago","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex 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Department of Medicine, Toronto General Hospital, University of Toronto, Ontario, Canada (M.H.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Skinner","sequence":"additional","affiliation":[{"name":"Cardiac Inherited Disease Group New Zealand, Paediatric and Congenital Cardiac Services, Starship Children\u2019s Hospital, Auckland (L.M., J.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan (T.A., K.S., W.S.)."},{"name":"Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"The Heart and Vascular Research Center, Metro-Health Campus, Case Western Reserve University, Cleveland, OH (E.S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Roden","sequence":"additional","affiliation":[{"name":"Departments of Medicine (M.B.S., N.C., D.M.R.), Vanderbilt University Medical Center, Nashville, TN."},{"name":"Pharmacology (D.M.R.), Vanderbilt University Medical Center, Nashville, TN."},{"name":"Biomedical Informatics (D.M.R.), Vanderbilt University Medical Center, Nashville, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Clinical Cardiovascular Research Center, University of Rochester Medical Center, NY (V.K., W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (A.M., I.T., L.C., A.B., D.K., B.S., C.S., Y.D.W., S.D., A.A.M.W., E.R.B., J.T.-H., J.P.K., F.D., 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