{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:00:20Z","timestamp":1769634020433,"version":"3.49.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,7,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The objective of this study was to evaluate the impact of left atrial appendage (LAA) exclusion on short-term outcomes in patients with atrial fibrillation undergoing isolated coronary artery bypass graft surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              We queried the 2010 to 2014 National Readmissions Database for patients who underwent coronary artery bypass graft repair with and without LAA ligation by using\n              <jats:italic>International Classification of Diseases, Ninth Revision, Clinical Modification<\/jats:italic>\n              procedure codes (\n              <jats:italic>International Classification of Diseases, Ninth Revision, Clinical Modification<\/jats:italic>\n              : 36.1xx). Only patients with a history of atrial fibrillation were included in our analysis. The primary outcome of our study was 30-day readmissions following discharge. Secondary outcomes were in-hospital mortality and stroke. To assess the postoperative outcomes, we used multivariate logistic regression models to adjust for clinical and demographic covariates.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In total, we analyzed 253 287 patients undergoing coronary artery bypass graft surgery, 7.0% of whom received LAA closure. LAA exclusion was associated with a greater risk of postoperative respiratory failure (8.2% versus 6.2%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and acute kidney injury (21.8% versus 18.5%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), but it did not significantly change the rate of blood transfusions or occurrence of cardiac tamponade. LAA exclusion was associated with a nonsignificant reduction in stroke (7.9% versus 8.6%,\n              <jats:italic>P<\/jats:italic>\n              =0.12), no difference in in-hospital mortality (2.2% versus 2.2%\n              <jats:italic>P<\/jats:italic>\n              =0.99), and a greater risk of 30-day readmission (16.0% versus 9.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). After covariate adjustment, LAA ligation remained a significant predictor of 30-day readmission (odds ratio, 1.640 [95% CI, 1.603\u20131.677],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>LAA exclusion during isolated coronary artery bypass graft surgery in patients with atrial fibrillation is associated with a higher rate of 30-day readmission. Postoperative measures to mitigate the loss of the hormonal and hemodynamic effects of the LAA may increase the therapeutic benefit of this procedure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.119.044642","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T09:00:20Z","timestamp":1591174820000},"page":"20-28","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Impact of Left Atrial Appendage Exclusion on Short-Term Outcomes in Isolated Coronary Artery Bypass Graft Surgery"],"prefix":"10.1161","volume":"142","author":[{"given":"Eitezaz","family":"Mahmood","sequence":"first","affiliation":[{"name":"Departments of Cardiothoracic Surgery (E.M., K.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."},{"name":"Department of Internal Medicine, North Shore University Hospital, Manhasset, NY (E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robina","family":"Matyal","sequence":"additional","affiliation":[{"name":"Anesthesia Critical Care and Pain Medicine (R.M., F.M., X.X., A.S., O.C., S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feroze","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Anesthesia Critical Care and Pain Medicine (R.M., F.M., X.X., A.S., O.C., S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinling","family":"Xu","sequence":"additional","affiliation":[{"name":"Anesthesia Critical Care and Pain Medicine (R.M., F.M., X.X., A.S., O.C., S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidan","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Anesthesia Critical Care and Pain Medicine (R.M., F.M., X.X., A.S., O.C., S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Anesthesia Critical Care and Pain Medicine (R.M., F.M., X.X., A.S., O.C., S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadia","family":"Karani","sequence":"additional","affiliation":[{"name":"Anesthesia Critical Care and Pain Medicine (R.M., F.M., X.X., A.S., O.C., S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7669-9426","authenticated-orcid":true,"given":"Kamal","family":"Khabbaz","sequence":"additional","affiliation":[{"name":"Departments of Cardiothoracic Surgery (E.M., K.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2013-000020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00887-X"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v10.i11.242"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1949.02900440011003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.10.076"},{"key":"e_1_3_3_8_2","volume-title":"NRD Overview","year":"2019","unstructured":"NRD Overview. Rockville, MD: Healthcare Cost and Utilization Project (HCUP); December 2019. https:\/\/www.hcup-us.ahrq.gov\/nrdoverview.jsp Cited August 10, 2019."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.071"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.03.037"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(97)00903-x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.063"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.9.3112"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0933"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(00)00419-x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.054"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021952"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.06.015"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux211"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.10.016"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.20125"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-012-0203-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087632"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2012.01422.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2225-319X.2013.12.06"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.119.044642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:49:58Z","timestamp":1715586598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.119.044642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7,7]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.119.044642"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.119.044642","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"2019-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}