{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:57:36Z","timestamp":1781593056501,"version":"3.54.5"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Individuals are exposed to air pollution and ionizing radiation from natural sources through inhalation of particles. This study investigates the association between cardiac arrhythmias and short-term exposures to fine particulate matter (particulate matter \u22642.5 \u00b5m aerodynamic diameter; PM\n              <jats:sub>2.5<\/jats:sub>\n              ) and particle radioactivity.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Ventricular arrhythmic events were identified among 176 patients with dual-chamber implanted cardioverter-defibrillators in Boston, Massachusetts between September 2006 and June 2010. Patients were assigned exposures based on residential addresses. Daily PM\n              <jats:sub>2.5<\/jats:sub>\n              levels were estimated at 1-km\u00d71-km grid cells from a previously validated prediction model. Particle gross \u03b2 activity was used as a surrogate for particle radioactivity and was measured from several monitoring sites by the US Environmental Protection Agency\u2019s monitoring network. The association of the onset of ventricular arrhythmias (VA) with 0- to 21-day moving averages of PM\n              <jats:sub>2.5<\/jats:sub>\n              and particle radioactivity (2 single-pollutant models and a 2-pollutant model) before the event was examined using time-stratified case-crossover analyses, adjusted for dew point and air temperatures.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total of 1,050 VA were recorded among 91 patients, including 123 sustained VA among 25 of these patients. In the single-pollutant model of PM\n              <jats:sub>2.5<\/jats:sub>\n              , each interquartile range increase in daily PM\n              <jats:sub>2.5<\/jats:sub>\n              levels for a 21-day moving average was associated with 39% higher odds of a VA event (95% CI, 12%\u201372%). In the single-pollutant model of particle radioactivity, each interquartile range increase in particle radioactivity for a 2-day moving average was associated with 13% higher odds of a VA event (95% CI, 1%\u201326%). In the 2-pollutant model, for the same averaging window of 21 days, each interquartile range increase in daily PM\n              <jats:sub>2.5<\/jats:sub>\n              was associated with an 48% higher odds of a VA event (95% CI, 15%\u201390%), and each interquartile range increase of particle radioactivity with a 10% lower odds of a VA event (95% CI, \u201329% to 14%). We found that with higher levels of particle radioactivity, the effect of PM\n              <jats:sub>2.5<\/jats:sub>\n              on VAs is reduced.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              In this high-risk population, intermediate (21-day) PM\n              <jats:sub>2.5<\/jats:sub>\n              exposure was associated with higher odds of a VA event onset among patients with known cardiac disease and indication for implanted cardioverter-defibrillator implantation independently of particle radioactivity.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.120.046321","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T09:01:30Z","timestamp":1593507690000},"page":"858-867","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Exposure to Air Pollution and Particle Radioactivity With the Risk of Ventricular Arrhythmias"],"prefix":"10.1161","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2192-198X","authenticated-orcid":true,"given":"Adjani A.","family":"Peralta","sequence":"first","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. Chan School of Public Health, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-9296","authenticated-orcid":true,"given":"Mark S.","family":"Link","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Department of Internal Medicine, Division of Cardiology, Cardiac Arrhythmia Service, Dallas (M.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. Chan School of Public Health, Boston, MA."},{"name":"Department of Epidemiology (J.S., D.W.D., M.A.M., F.L.), Harvard T.H. Chan School of Public Health, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Luttmann-Gibson","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. Chan School of Public Health, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Dockery","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. Chan School of Public Health, Boston, MA."},{"name":"Department of Epidemiology (J.S., D.W.D., M.A.M., F.L.), Harvard T.H. Chan School of Public Health, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1360-2580","authenticated-orcid":true,"given":"Annelise","family":"Blomberg","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. Chan School of Public Health, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-7510","authenticated-orcid":true,"given":"Yaguang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. 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Chan School of Public Health, Boston, MA."},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA (D.R.G., F.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Laden","sequence":"additional","affiliation":[{"name":"Department of Environmental Health (A.A.P., J.S., H.L.-G., D.W.D., A.B., Y.W., D.R.G., F.L., P.K.), Harvard T.H. Chan School of Public Health, Boston, MA."},{"name":"Department of Epidemiology (J.S., D.W.D., M.A.M., F.L.), Harvard T.H. Chan School of Public Health, Boston, MA."},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA (D.R.G., F.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Coull","sequence":"additional","affiliation":[{"name":"Department of Biostatistics (B.A.C.), Harvard T.H. 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