{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:29:19Z","timestamp":1791430159893,"version":"4.3.3"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,8,25]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Streptococci frequently cause infective endocarditis (IE), yet the prevalence of IE in patients with bloodstream infections (BSIs) caused by different streptococcal species is unknown. We aimed to investigate the prevalence of IE at species level in patients with streptococcal BSIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We investigated all patients with streptococcal BSIs, from 2008 to 2017, in the Capital Region of Denmark. Data were crosslinked with Danish nationwide registries for identification of concomitant hospitalization with IE. In a multivariable logistic regression analysis, we investigated the risk of IE according to streptococcal species adjusted for age, sex, \u22653 positive blood culture bottles, native valve disease, prosthetic valve, previous IE, and cardiac device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 6506 cases with streptococcal BSIs (mean age 68.1 years [SD 16.2], 52.8% men) the IE prevalence was 7.1% (95% CI, 6.5\u20137.8). The lowest IE prevalence was found with\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic>S pneumoniae<\/jats:italic>\n                      ) 1.2% (0.8\u20131.6) and\n                      <jats:italic>Spyogenes<\/jats:italic>\n                      1.9% (0.9\u20133.3). An intermediary IE prevalence was found with\n                      <jats:italic>Sanginosus<\/jats:italic>\n                      4.8% (3.0\u20137.3),\n                      <jats:italic>Ssalivarius<\/jats:italic>\n                      5.8% (2.9\u201310.1), and\n                      <jats:italic>Sagalactiae<\/jats:italic>\n                      9.1% (6.6\u201312.1). The highest IE prevalence was found with\n                      <jats:italic>Smitis\/oralis<\/jats:italic>\n                      19.4% (15.6\u201323.5),\n                      <jats:italic>Sgallolyticus<\/jats:italic>\n                      (formerly\n                      <jats:italic>Sbovis<\/jats:italic>\n                      ) 30.2% (24.3\u201336.7),\n                      <jats:italic>Ssanguinis<\/jats:italic>\n                      34.6% (26.6\u201343.3),\n                      <jats:italic>Sgordonii<\/jats:italic>\n                      44.2% (34.0\u201354.8), and\n                      <jats:italic>Smutans<\/jats:italic>\n                      47.9% (33.3\u201362.8). In multivariable analysis using\n                      <jats:italic>S pneumoniae<\/jats:italic>\n                      as reference, all species except\n                      <jats:italic>S pyogenes<\/jats:italic>\n                      were associated with significantly higher IE risk, with the highest risk found with\n                      <jats:italic>S gallolyticus<\/jats:italic>\n                      odds ratio (OR) 31.0 (18.8\u201351.1),\n                      <jats:italic>S mitis\/oralis<\/jats:italic>\n                      OR 31.6 (19.8\u201350.5),\n                      <jats:italic>S sanguinis<\/jats:italic>\n                      OR 59.1 (32.6\u2013107),\n                      <jats:italic>S gordonii<\/jats:italic>\n                      OR 80.8 (43.9\u2013149), and\n                      <jats:italic>S mutans<\/jats:italic>\n                      OR 81.3 (37.6\u2013176).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The prevalence of IE in streptococcal BSIs is species dependent with\n                      <jats:italic>S mutans, S gordonii, S sanguinis, S gallolyticus<\/jats:italic>\n                      , and\n                      <jats:italic>S mitis\/oralis<\/jats:italic>\n                      having the highest IE prevalence and the highest associated IE risk after adjusting for IE risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.120.046723","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T05:01:03Z","timestamp":1593061263000},"page":"720-730","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":179,"title":["Prevalence of Infective Endocarditis in Streptococcal Bloodstream Infections Is Dependent on Streptococcal Species"],"prefix":"10.1161","volume":"142","author":[{"given":"Sandra","family":"Chamat-Hedemand","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital, Roskilde, Denmark (S.C.-H., N.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark (S.C.-H., A.D., L.B.O., T.K.L., G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauge","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Denmark (L.\u00d8., E.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Arpi","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital Herlev-Gentofte, Denmark (M.A., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Denmark (L.\u00d8., E.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Boel","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital Herlev-Gentofte, Denmark (M.A., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Bruun","family":"Oestergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark (S.C.-H., A.D., L.B.O., T.K.L., G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine K.","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark (S.C.-H., A.D., L.B.O., T.K.L., G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-402X","authenticated-orcid":true,"given":"Gunnar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark (S.C.-H., A.D., L.B.O., T.K.L., G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Research, Nordsjaellands Hospital, Hiller\u00f8d, Denmark (C.T.-P.)."},{"name":"Department of Cardiology, Aalborg University Hospital, Denmark (C.T.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Eske","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital, Roskilde, Denmark (S.C.-H., 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