{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:51Z","timestamp":1793137011099,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,7,21]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop and validate a SCD risk prediction model in pediatric hypertrophic cardiomyopathy to guide SCD prevention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In an international multicenter observational cohort study, phenotype-positive patients with isolated hypertrophic cardiomyopathy &lt;18 years of age at diagnosis were eligible. The primary outcome variable was the time from diagnosis to a composite of SCD events at 5-year follow-up: SCD, resuscitated sudden cardiac arrest, and aborted SCD, that is, appropriate shock following primary prevention implantable cardioverter defibrillators. Competing risk models with cause-specific hazard regression were used to identify and quantify clinical and genetic factors associated with SCD. The cause-specific regression model was implemented using boosting, and tuned with 10 repeated 4-fold cross-validations. The final model was fitted using all data with the tuned hyperparameter value that maximizes the c-statistic, and its performance was characterized by using the c-statistic for competing risk models. The final model was validated in an independent external cohort (SHaRe [Sarcomeric Human Cardiomyopathy Registry], n=285).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall, 572 patients met eligibility criteria with 2855 patient-years of follow-up. The 5-year cumulative proportion of SCD events was 9.1% (14 SCD, 25 resuscitated sudden cardiac arrests, and 14 aborted SCD). Risk predictors included age at diagnosis, documented nonsustained ventricular tachycardia, unexplained syncope, septal diameter\n                      <jats:italic>z<\/jats:italic>\n                      -score, left ventricular posterior wall diameter\n                      <jats:italic>z<\/jats:italic>\n                      score, left atrial diameter\n                      <jats:italic>z<\/jats:italic>\n                      score, peak left ventricular outflow tract gradient, and presence of a pathogenic variant. Unlike in adults, left ventricular outflow tract gradient had an inverse association, and family history of SCD had no association with SCD. Clinical and clinical\/genetic models were developed to predict 5-year freedom from SCD. Both models adequately discriminated between patients with and without SCD events with a c-statistic of 0.75 and 0.76, respectively, and demonstrated good agreement between predicted and observed events in the primary and validation cohorts (validation c-statistic 0.71 and 0.72, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study provides a validated SCD risk prediction model with &gt;70% prediction accuracy and incorporates risk factors that are unique to pediatric hypertrophic cardiomyopathy. An individualized risk prediction model has the potential to improve the application of clinical practice guidelines and shared decision making for implantable cardioverter defibrillator insertion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT0403679.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.120.047235","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:00:39Z","timestamp":1589778039000},"page":"217-229","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":218,"title":["A Validated Model for Sudden Cardiac Death Risk Prediction in Pediatric Hypertrophic Cardiomyopathy"],"prefix":"10.1161","volume":"142","clinical-trial-number":[{"clinical-trial-number":"nct0403679","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Anastasia","family":"Miron","sequence":"first","affiliation":[{"name":"Division of Cardiology (A.M., T.P., S.M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Lafreniere-Roula","sequence":"additional","affiliation":[{"name":"Ted Rogers Computational Program, Ted Rogers Center for Heart Research, The Hospital for Sick Children, University Health Network, Toronto, Ontario, Canada (M.L.-R., C.-P, S.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Po","family":"Steve Fan","sequence":"additional","affiliation":[{"name":"Ted Rogers Computational Program, Ted Rogers Center for Heart Research, The Hospital for Sick Children, University Health Network, Toronto, Ontario, Canada (M.L.-R., C.-P, S.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katey R.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Vancouver, Canada (K.R.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Dragulescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.D., V.B.L., L.N.B., A.J., E.J.-St-M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Papaz","sequence":"additional","affiliation":[{"name":"Division of Cardiology (A.M., T.P., S.M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Manlhiot","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins Medical Center, Baltimore, MD (C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Lucile Packard Children\u2019s Hospital Stanford, Palo Alto, CA (B.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Butts","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Children\u2019s Medical Center of Dallas, TX (R.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Gardin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Children\u2019s Hospital of Eastern Ontario, Ottawa, Ontario, Canada (L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Ontario, Canada (E.A.S., S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor S.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Pediatric Cardiology, Baylor College of Medicine, Texas Children\u2019s Hospital (T.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete F.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Congenital Heart Disease, Pediatric Electrophysiology and Pacing, Cleveland Clinic Children\u2019s Hospital, OH (P.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seshadri","family":"Balaji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Oregon Health &amp; Science University, OHSU Doernbecher Children\u2019s Hospital, Portland (S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie Beaus\u00e9jour","family":"Ladouceur","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.D., V.B.L., L.N.B., A.J., E.J.-St-M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee N.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.D., V.B.L., L.N.B., A.J., E.J.-St-M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Colan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, MA (S.D.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Godown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Monroe Carrell Jr Children\u2019s Hospital at Vanderbilt, Nashville, TN (J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather T.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Pediatrics, Medical University of South Carolina, Charleston (H.T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie","family":"Ingles","sequence":"additional","affiliation":[{"name":"Agnes Ginges Center for Molecular Cardiology at Centenary Institute, The University of Sydney, New South Wales, Australia (J.I., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Jeewa","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.D., V.B.L., L.N.B., A.J., E.J.-St-M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Jefferies","sequence":"additional","affiliation":[{"name":"Division of Adult Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis (J.L.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin K.","family":"Lal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, University of Utah Primary Children\u2019s Hospital, Salt Lake City (A.K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Royal Children\u2019s Hospital, Melbourne, Victoria, Australia (J.M., R.G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Jean-St-Michel","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.D., V.B.L., L.N.B., A.J., E.J.-St-M.), Hospital for Sick Children, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Michels","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus MC Rotterdam, South Holland, Netherlands (M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children\u2019s Hospital Colorado, Aurora (S.J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[{"name":"Referral Center for Cardiomyopathies, Careggi University Hospital, Florence, Italy (I.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Parent","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Riley Children\u2019s Hospital, Indianapolis, IN (J.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Brazil (A.C.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Semsarian","sequence":"additional","affiliation":[{"name":"Agnes Ginges Center for Molecular Cardiology at Centenary Institute, The University of Sydney, New South Wales, Australia (J.I., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Whitehill","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children\u2019s Healthcare of Atlanta, GA (R.D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel G.","family":"Wittekind","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital, OH (S.G.W., C.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Russell","sequence":"additional","affiliation":[{"name":"Pediatrics, C.S. Mott Children\u2019s Hospital, Ann Arbor, MI (M.W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Conway","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Stollery Children\u2019s Hospital, Edmonton, AB, Canada (J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Columbia University College of Physicians and Surgeons\/Morgan Stanley Children\u2019s Hospital, New York, NY (M.E.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chet","family":"Villa","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital, OH (S.G.W., C.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Royal Children\u2019s Hospital, Melbourne, Victoria, Australia (J.M., R.G.W.)."},{"name":"Murdoch Children\u2019s Research Institute, University of Melbourne, Victoria, Australia (R.G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Rossano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children\u2019s Hospital of Philadelphia, PA (J.W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Kantor","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Children\u2019s Hospital of Los Angeles, CA (P.F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn Y.","family":"Ho","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (C.Y.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-4484","authenticated-orcid":true,"given":"Seema","family":"Mital","sequence":"additional","affiliation":[{"name":"Division of Cardiology (A.M., T.P., S.M.), Hospital for Sick Children, Toronto, Ontario, Canada."},{"name":"Department of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, University of Toronto, Ontario, Canada (E.A.S., S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6120118"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.4.785"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.019"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.011"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.079"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303271"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz118"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.037"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2018.03.001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.0789"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy219"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.094730"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001569"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005820"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/ac.65.5.2056238"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2018.08.011"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.033"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030437"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht439"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315694"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-313700"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.134.suppl_1.17056"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033200"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.108.836478"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.10.027"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.06.018"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.1391"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.2861"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/9781118742440.app1","volume-title":"In: Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult","author":"Colan SD","year":"2016","unstructured":"Colan, SD. Normal echocardiographic values for cardiovascular structures. Lai, WW, Mertens, LL, Cohen, MS. eds. In: Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult. 2nd ed. Hoboken, NJ: John Wiley & Sons Ltd; 2016:883\u2013901.","edition":"2"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/9781118742440.ch5","volume-title":"In: Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult","author":"Sluysmans T","year":"2016","unstructured":"Sluysmans, T, Colan, SD. Structural measurements and adjustments for growth. Lai, WW, Mertens, LL, Cohen, MS. eds. In: Echocardiography in Pediatric and Congenital Heart Disease: From Fetus to Adult. 2nd ed. Hoboken, NJ: John Wiley & Sons Ltd; 2016:61\u201372.","edition":"2"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2712"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-7-33"},{"key":"e_1_3_4_35_2","volume-title":"In: Flexible Imputation of Missing Data. Advanced Techniques Part 2","author":"Graham JW","year":"2018","unstructured":"Graham, JW. Imputation in practice. Van Buuren, S, ed. In: Flexible Imputation of Missing Data. Advanced Techniques Part 2. 2nd ed. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2018.","edition":"2"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxt059"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2016:30:2"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.4.405"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.061"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000963"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13157"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.04.040"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20190045"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028895"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.783654"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.108.821314"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw268"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.120.047235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:51:10Z","timestamp":1715572270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.120.047235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,21]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7,21]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.120.047235"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.120.047235","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,21]]},"assertion":[{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}