{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:24Z","timestamp":1791410904626,"version":"4.3.3"},"reference-count":137,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2021,3,9]]},"abstract":"<jats:p>After 15 years of successive randomized, controlled trials, indications for transcatheter aortic valve replacement (TAVR) are rapidly expanding. In the coming years, this procedure could become the first line treatment for patients with a symptomatic severe aortic stenosis and a tricuspid aortic valve anatomy. However, randomized, controlled trials have excluded bicuspid aortic valve (BAV), which is the most frequent congenital heart disease occurring in 1% to 2% of the total population and representing at least 25% of patients 80 years of age or older referred for aortic valve replacement. The use of a less invasive transcatheter therapy in this elderly population became rapidly attractive, and approximately 10% of patients currently undergoing TAVR have a BAV. The U.S. Food and Drug Administration and the \u201cEuropean Conformity\u201d have approved TAVR for low-risk patients regardless of the aortic valve anatomy whereas international guidelines recommend surgical replacement in BAV populations. Given this progressive expansion of TAVR toward younger and lower-risk patients, heart teams are encountering BAV patients more frequently, while the ability of this therapy to treat such a challenging anatomy remains uncertain. This review will address the singularity of BAV anatomy and associated technical challenges for the TAVR procedure. We will examine and summarize available clinical evidence and highlight critical knowledge gaps regarding TAVR utilization in BAV patients. We will provide a comprehensive overview of the role of computed tomography scans in the diagnosis, and classification of BAV and TAVR procedure planning. Overall, we will offer an integrated framework for understanding the current role of TAVR in the treatment of bicuspid aortic stenosis and for guiding physicians in clinical decision-making.<\/jats:p>","DOI":"10.1161\/circulationaha.120.048048","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T14:00:17Z","timestamp":1615212017000},"page":"1043-1061","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":201,"title":["Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis"],"prefix":"10.1161","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-1473","authenticated-orcid":true,"given":"Flavien","family":"Vincent","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire de Lille, Institut C\u0153ur Poumon, Cardiology, Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases (F.V., T.D., C.D., N.D., B.V., B.S., T.P., H.S., G.S., E.VB.)"},{"name":"Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- European Genomic Institute for Diabetes, F-59000 Lille, France (F.V., E.VB.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York (F.V., B.R., M. 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Shen, P.P.)."},{"name":"H\u00f4pital Cardiologique Haut-L\u00e9v\u00eaque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France (J.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Denimal","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Lille, Institut C\u0153ur Poumon, Cardiology, Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases (F.V., T.D., C.D., N.D., B.V., B.S., T.P., H.S., G.S., E.VB.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myl\u00e8ne","family":"Shen","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval\/Qu\u00e9bec Heart and Lung Institute, Laval University, Canada (F.V., J.T., M. 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