{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:08:15Z","timestamp":1792094895648,"version":"4.4.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to treat cardiogenic shock. However, VA-ECMO might hamper myocardial recovery. The Impella unloads the left ventricle. This study aimed to evaluate whether left ventricular unloading in patients with cardiogenic shock treated with VA-ECMO was associated with lower mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Data from 686 consecutive patients with cardiogenic shock treated with VA-ECMO with or without left ventricular unloading using an Impella at 16 tertiary care centers in 4 countries were collected. The association between left ventricular unloading and 30-day mortality was assessed by Cox regression models in a 1:1 propensity score\u2013matched cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Left ventricular unloading was used in 337 of the 686 patients (49%). After matching, 255 patients with left ventricular unloading were compared with 255 patients without left ventricular unloading. In the matched cohort, left ventricular unloading was associated with lower 30-day mortality (hazard ratio, 0.79 [95% CI, 0.63\u20130.98];\n              <jats:italic>P<\/jats:italic>\n              =0.03) without differences in various subgroups. Complications occurred more frequently in patients with left ventricular unloading: severe bleeding in 98 (38.4%) versus 45 (17.9%), access site\u2013related ischemia in 55 (21.6%) versus 31 (12.3%), abdominal compartment in 23 (9.4%) versus 9 (3.7%), and renal replacement therapy in 148 (58.5%) versus 99 (39.1%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In this international, multicenter cohort study, left ventricular unloading was associated with lower mortality in patients with cardiogenic shock treated with VA-ECMO, despite higher complication rates. These findings support use of left ventricular unloading in patients with cardiogenic shock treated with VA-ECMO and call for further validation, ideally in a randomized, controlled trial.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.120.048792","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T09:00:14Z","timestamp":1602234014000},"page":"2095-2106","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":475,"title":["Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation"],"prefix":"10.1161","volume":"142","author":[{"given":"Benedikt","family":"Schrage","sequence":"first","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Moritz","family":"Becher","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-8091","authenticated-orcid":true,"given":"Alexander","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery (A.B., H.R.), University Heart and Vascular Center Hamburg, Germany."},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiram","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Tampa General Hospital, University of South Florida (H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Brunner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I (S. Brunner, D.K., M.O.), LMU Klinikum, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Colson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, CHU Montpellier, University Montpellier, France (P.C., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaston","family":"Cudemus Deseda","sequence":"additional","affiliation":[{"name":"Division of Anesthesia, Critical Care and Pain Medicine (G.C.D.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-0743","authenticated-orcid":true,"given":"Salim","family":"Dabboura","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Eckner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Paracelsus Medical University N\u00fcrnberg, Germany (D.E., M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Eden","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"Department of Internal Medicine III, Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany(M.E., D.F., N.F., C.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Germany (I.E., T.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derk","family":"Frank","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"Department of Internal Medicine III, Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany(M.E., D.F., N.F., C.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"Department of Internal Medicine III, Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany(M.E., D.F., N.F., C.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-6671","authenticated-orcid":true,"given":"Masaki","family":"Funamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery (M.F., D.M.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-5593","authenticated-orcid":true,"given":"Alina","family":"Go\u00dfling","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Graf","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Germany (I.E., T.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hagl","sequence":"additional","affiliation":[{"name":"Herzchirurgische Klinik und Poliklinik (C.H.), LMU Klinikum, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulus","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."},{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"Institute of Cardiovascular Sciences, University of Birmingham and University Hospitals Birmingham and Sandwell and West Birmingham National Health ServiceTrusts, United Kingdom (P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6125-4114","authenticated-orcid":true,"given":"Danny","family":"Kupka","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (B.S., P.M.B., S. Blankenberg, S.D., A.G., P.K., D.W.), University Heart and Vascular Center Hamburg, Germany."},{"name":"Medizinische Klinik und Poliklinik I (S. Brunner, D.K., M.O.), LMU Klinikum, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Benjamin, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Germany (U.L., C.S.)."},{"name":"Franklin\/German Centre for Cardiovascular Research (DZHK), partner site Berlin\/Institute of Health (BIH), Germany (U.L., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Lipinski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of California, San Diego (J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Lopes","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA (M.L., D.A.M., A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Majunke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Germany (N.M., M.S., L.S., H.T., F.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Maniuc","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I (S. Brunner, D.K., M.O.), LMU Klinikum, Munich, Germany."},{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Germany (O.M., P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"McGrath","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery (M.F., D.M.), Massachusetts General Hospital, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1319-6738","authenticated-orcid":true,"given":"Sven","family":"M\u00f6bius-Winkler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Jena, Germany (S.M.-W., P.C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-5382","authenticated-orcid":true,"given":"David A.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA (M.L., D.A.M., A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, CHU Montpellier, University Montpellier, France (P.C., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curt","family":"Noel","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."},{"name":"Department of Internal Medicine III, Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany(M.E., D.F., N.F., C.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nordbeck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital W\u00fcrzburg, Germany (O.M., P.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9830-1941","authenticated-orcid":true,"given":"Martin","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Mechanical Circulatory Support Program, Vita Salute University, Milan, Italy (F.P., V.P.)."},{"name":"Department of Anesthesia and Intensive Care, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) ISMETT (Istituto Mediterraneo trapianti e terapie avanzate), UPMC (University of Pittsburgh Medical Center)Italy, Palermo, Italy (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, St. Rita\u2019s Medical Center, Lima, OH (S.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Pauschinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Paracelsus Medical University N\u00fcrnberg, Germany (D.E., M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-4230","authenticated-orcid":true,"given":"Vittorio","family":"Pazzanese","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Mechanical Circulatory Support Program, Vita Salute University, Milan, Italy (F.P., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery (A.B., H.R.), University Heart and Vascular Center Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Sandri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Germany (N.M., M.S., L.S., H.T., F.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9442-7141","authenticated-orcid":true,"given":"P. Christian","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Jena, Germany (S.M.-W., P.C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"H.G. Schwinger","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II, Klinikum Weiden, Germany (R.H.G.S., L.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Malte","family":"Sinning","sequence":"additional","affiliation":[{"name":"University Heart Center Bonn, Department of Cardiology, Germany (J.-M.S., A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-9078","authenticated-orcid":true,"given":"Adem","family":"Aksoy","sequence":"additional","affiliation":[{"name":"University Heart Center Bonn, Department of Cardiology, Germany (J.-M.S., A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Skurk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Campus Benjamin, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Germany (U.L., C.S.)."},{"name":"Franklin\/German Centre for Cardiovascular Research (DZHK), partner site Berlin\/Institute of Health (BIH), Germany (U.L., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Szczanowicz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Germany (N.M., M.S., L.S., H.T., F.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":true,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Germany (N.M., M.S., L.S., H.T., F.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Tietz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Germany (N.M., M.S., L.S., H.T., F.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubodh","family":"Varshney","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA (M.L., D.A.M., A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Wechsler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II, Klinikum Weiden, Germany (R.H.G.S., L.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-1956","authenticated-orcid":true,"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK), partner site Hamburg\/L\u00fcbeck\/Kiel, Germany (B.S., P.M.B., A.B., S. Blankenberg, S.D., M.E., I.E., D.F., N.F., T.G., P.K., C.N., D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036691"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz363"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.044"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.09.009"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.085"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.668"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000767"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000629"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005853"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_3_4_13_2","volume-title":"R: A language and environment for statistical computing [computer program]","year":"2010","unstructured":"R: A language and environment for statistical computing [computer program]. Vienna, AustriaR Foundation for Statistical Computing2010"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.038"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28329"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.037"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001039"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005618"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040931"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1808788"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208410"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.02.004"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.09.008"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030677"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036614"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0254"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044007"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13319"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2018.12.09"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0267659119827231"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000660"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.120.048792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:37:03Z","timestamp":1715585823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.120.048792"}},"subtitle":["Results From an International, Multicenter Cohort Study"],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":31,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.120.048792"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.120.048792","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"2020-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}