{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:13:11Z","timestamp":1792253591842,"version":"4.4.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2021,5,25]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the\n                      <jats:italic>FBN1<\/jats:italic>\n                      (fibrillin-1) gene encoding a large glycoprotein in the extracellular matrix called fibrillin-1. The major complication of this connective disorder is the risk to develop thoracic aortic aneurysm. To date, no effective pharmacologic therapies have been identified for the management of thoracic aortic disease and the only options capable of preventing aneurysm rupture are endovascular repair or open surgery. Here, we have studied the role of mitochondrial dysfunction in the progression of thoracic aortic aneurysm and mitochondrial boosting strategies as a potential treatment to managing aortic aneurysms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Combining transcriptomics and metabolic analysis of aortas from an MFS mouse model (\n                      <jats:italic>Fbn1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>c1039g\/+<\/jats:italic>\n                      <\/jats:sup>\n                      ) and MFS patients, we have identified mitochondrial dysfunction alongside with mtDNA depletion as a new hallmark of aortic aneurysm disease in MFS. To demonstrate the importance of mitochondrial decline in the development of aneurysms, we generated a conditional mouse model with mitochondrial dysfunction specifically in vascular smooth muscle cells (VSMC) by conditional depleting Tfam (mitochondrial transcription factor A;\n                      <jats:italic>Myh11-Cre<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>ERT2<\/jats:italic>\n                      <\/jats:sup>\n                      <jats:italic>Tfam<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>flox\/flox<\/jats:italic>\n                      <\/jats:sup>\n                      mice). We used a mouse model of MFS to test for drugs that can revert aortic disease by enhancing Tfam levels and mitochondrial respiration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The main canonical pathways highlighted in the transcriptomic analysis in aortas from\n                      <jats:italic>Fbn1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>c1039g\/+<\/jats:italic>\n                      <\/jats:sup>\n                      mice were those related to metabolic function, such as mitochondrial dysfunction. Mitochondrial complexes, whose transcription depends on Tfam and mitochondrial DNA content, were reduced in aortas from young\n                      <jats:italic>Fbn1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>c1039g\/+<\/jats:italic>\n                      <\/jats:sup>\n                      mice. In vitro experiments in\n                      <jats:italic>Fbn1<\/jats:italic>\n                      -silenced VSMCs presented increased lactate production and decreased oxygen consumption. Similar results were found in MFS patients. VSMCs seeded in matrices produced by Fbn1-deficient VSMCs undergo mitochondrial dysfunction. Conditional Tfam-deficient VSMC mice lose their contractile capacity, showed aortic aneurysms, and died prematurely. Restoring mitochondrial metabolism with the NAD precursor nicotinamide riboside rapidly reverses aortic aneurysm in\n                      <jats:italic>Fbn1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>c1039g\/+<\/jats:italic>\n                      <\/jats:sup>\n                      mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Mitochondrial function of VSMCs is controlled by the extracellular matrix and drives the development of aortic aneurysm in Marfan syndrome. Targeting vascular metabolism is a new available therapeutic strategy for managing aortic aneurysms associated with genetic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.120.051171","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T05:00:47Z","timestamp":1615525247000},"page":"2091-2109","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":153,"title":["Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm"],"prefix":"10.1161","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-2954","authenticated-orcid":true,"given":"Jorge","family":"Oller","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., M.M.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Spain (J.O., R.R-D., R.R-M., A.M.B., J.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-8714","authenticated-orcid":true,"given":"Enrique","family":"Gaband\u00e9-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Ruiz-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (M.J.R-R., J.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8136-4145","authenticated-orcid":true,"given":"Gabriela","family":"Desd\u00edn-Mic\u00f3","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Aranda","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-1505","authenticated-orcid":true,"given":"Raquel","family":"Rodrigues-Diez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Spain (J.O., R.R-D., R.R-M., A.M.B., J.M.R.)."},{"name":"Departamento de Farmacolog\u00eda, Universidad Aut\u00f3noma de Madrid, Instituto de Investigaci\u00f3n Hospital La Paz, Spain (R.R-D., C.B-M., A.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-0459","authenticated-orcid":true,"given":"Constanza","family":"Ballesteros-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Universidad Aut\u00f3noma de Madrid, Instituto de Investigaci\u00f3n Hospital La Paz, Spain (R.R-D., C.B-M., A.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-1827","authenticated-orcid":true,"given":"Eva Mar\u00eda","family":"Blanco","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Roldan-Montero","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Spain (J.O., R.R-D., R.R-M., A.M.B., J.M.R.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jimenez Diaz, Madrid, Spain (R.R-M. J.L.M-V.)."},{"name":"Hospital Universitario Puerta de Hierro, Madrid, Spain. (R.R-M., J.L.M-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Acu\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Forteza Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Mart\u00edn-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Francisco","family":"Nistal","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain. (J.F.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Lino Cardenas","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Thoracic Aortic Center, Boston (C.L.L.C., M.E.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Evan","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Thoracic Aortic Center, Boston (C.L.L.C., M.E.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Mart\u00edn-Ventura","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jimenez Diaz, Madrid, Spain (R.R-M. J.L.M-V.)."},{"name":"Hospital Universitario Puerta de Hierro, Madrid, Spain. (R.R-M., J.L.M-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Briones","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Spain (J.O., R.R-D., R.R-M., A.M.B., J.M.R.)."},{"name":"Departamento de Farmacolog\u00eda, Universidad Aut\u00f3noma de Madrid, Instituto de Investigaci\u00f3n Hospital La Paz, Spain (R.R-D., C.B-M., A.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-9122","authenticated-orcid":true,"given":"Juan","family":"Miguel Redondo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital 12 de Octubre (i+12), Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., M.M.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Spain (J.O., R.R-D., R.R-M., A.M.B., J.M.R.)."},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (M.J.R-R., J.M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-8762","authenticated-orcid":true,"given":"Mar\u00eda","family":"Mittelbrunn","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas Universidad Aut\u00f3noma de Madrid, Spain (J.O., E.G-R., G.D-M., J.F.A., E.M.B., P.A., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300675"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312436"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.693523"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055695"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421001"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.025056"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/415168a"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31771"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy006"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313187"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312787"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0286-3"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.07.075"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(77)80005-2"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2010.01241.x"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165587"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3537"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.042"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.08.017"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1998-1"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-231"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.003"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax0860"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.232591499"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308710100"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1666"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110503"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00494-15"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4266"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-413-1_19"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152124"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13257"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.11.011"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041460"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.304936"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.023"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4854"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.005"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.04.008"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2693"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.04.001"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.310022"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy150"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304412"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081812"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.037"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-018-0008-5"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06376-x"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.646984"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15327"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv575"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.052"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.06.216"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.120.051171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:39:49Z","timestamp":1715575189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.120.051171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":57,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,5,25]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.120.051171"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.120.051171","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"2020-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}