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Yet, patients undergoing transcatheter cardiac interventions require antithrombotic therapy before, during, or after the procedure to prevent thromboembolic events. However, these therapies are associated with an increased risk of bleeding complications. To date, challenges and controversies exist regarding balancing the risk of thrombotic and bleeding complications in these patients such that the optimal antithrombotic regimens to adopt in each specific procedure is still unclear. In this review, we summarize current evidence on antithrombotic therapies for device-based transcatheter interventions targeting structural heart disease and emphasize the importance of a tailored approach in these patients.<\/jats:p>","DOI":"10.1161\/circulationaha.121.054305","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T23:09:10Z","timestamp":1634598550000},"page":"1323-1343","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":75,"title":["Antithrombotic Therapy in Patients Undergoing Transcatheter Interventions for Structural Heart Disease"],"prefix":"10.1161","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-830X","authenticated-orcid":true,"given":"Paolo","family":"Calabr\u00f2","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli,\u201d Naples, Italy (P.C., F.G., E.M., A.C.)."},{"name":"Division of Cardiology, A.O.R.N. \u201cSant\u2019Anna e San Sebastiano,\u201d Caserta, Italy (P.C., F.G., E.M., A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Gragnano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli,\u201d Naples, Italy (P.C., F.G., E.M., A.C.)."},{"name":"Division of Cardiology, A.O.R.N. \u201cSant\u2019Anna e San Sebastiano,\u201d Caserta, Italy (P.C., F.G., E.M., A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Niccoli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. 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