{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:37:55Z","timestamp":1790699875790,"version":"4.1.0"},"reference-count":76,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Autoimmunity is increasingly recognized as a key contributing factor in heart muscle diseases. The functional features of cardiac autoimmunity in humans remain undefined because of the challenge of studying immune responses in situ. We previously described a subset of c-mesenchymal epithelial transition factor (c-Met)\u2013expressing (c-Met\n              <jats:sup>+<\/jats:sup>\n              ) memory T lymphocytes that preferentially migrate to cardiac tissue in mice and humans.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              In-depth phenotyping of peripheral blood T cells, including c-Met\n              <jats:sup>+<\/jats:sup>\n              T cells, was undertaken in groups of patients with inflammatory and noninflammatory cardiomyopathies, patients with noncardiac autoimmunity, and healthy controls. Validation studies were carried out using human cardiac tissue and in an experimental model of cardiac inflammation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              We show that c-Met\n              <jats:sup>+<\/jats:sup>\n              T cells are selectively increased in the circulation and in the myocardium of patients with inflammatory cardiomyopathies. The phenotype and function of c-Met\n              <jats:sup>+<\/jats:sup>\n              T cells are distinct from those of c-Met\u2013negative (c-Met\n              <jats:sup>\u2212<\/jats:sup>\n              ) T cells, including preferential proliferation to cardiac myosin and coproduction of multiple cytokines (interleukin-4, interleukin-17, and interleukin-22). Furthermore, circulating c-Met\n              <jats:sup>+<\/jats:sup>\n              T cell subpopulations in different heart muscle diseases identify distinct and overlapping mechanisms of heart inflammation. In experimental autoimmune myocarditis, elevations in autoantigen-specific c-Met\n              <jats:sup>+<\/jats:sup>\n              T cells in peripheral blood mark the loss of immune tolerance to the heart. Disease development can be halted by pharmacologic c-Met inhibition, indicating a causative role for c-Met\n              <jats:sup>+<\/jats:sup>\n              T cells.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              Our study demonstrates that the detection of circulating c-Met\n              <jats:sup>+<\/jats:sup>\n              T cells may have use in the diagnosis and monitoring of adaptive cardiac inflammation and definition of new targets for therapeutic intervention when cardiac autoimmunity causes or contributes to progressive cardiac injury.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.121.055610","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:14Z","timestamp":1669248014000},"page":"1930-1945","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Circulating c-Met\u2013Expressing Memory T Cells Define Cardiac Autoimmunity"],"prefix":"10.1161","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2505-7102","authenticated-orcid":true,"given":"Silvia","family":"Fanti","sequence":"first","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Stephenson","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-7237","authenticated-orcid":true,"given":"Etel","family":"Rocha-Vieira","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Federal University of Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil (E.R.-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-7212","authenticated-orcid":true,"given":"Alexandros","family":"Protonotarios","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."},{"name":"Institute of Cardiovascular Science, University College London, UK (A.P., P.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-9615","authenticated-orcid":true,"given":"Stavroula","family":"Kanoni","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriomina","family":"Shahaj","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-4594","authenticated-orcid":true,"given":"M. Paula","family":"Longhi","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-1509","authenticated-orcid":true,"given":"Vishal S.","family":"Vyas","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-8504","authenticated-orcid":true,"given":"Carlene","family":"Dyer","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-0344","authenticated-orcid":true,"given":"Elena","family":"Pontarini","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9886-6870","authenticated-orcid":true,"given":"Angeliki","family":"Asimaki","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Science Institute, St George\u2019s, University of London, UK (A.A., C.B.-B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4626-1276","authenticated-orcid":true,"given":"Carlos","family":"Bueno-Beti","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Science Institute, St George\u2019s, University of London, UK (A.A., C.B.-B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-4883","authenticated-orcid":true,"given":"Monica","family":"De Gaspari","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (M.D.G., S.R., C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-1748","authenticated-orcid":true,"given":"Stefania","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (M.D.G., S.R., C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-9753","authenticated-orcid":true,"given":"Cristina","family":"Basso","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (M.D.G., S.R., C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bombardieri","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Coe","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosu","family":"Wang","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-4252","authenticated-orcid":true,"given":"Daniel","family":"Harding","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-7235","authenticated-orcid":true,"given":"Iain","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences &amp; Sport, University of Stirling, UK (I.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-0049","authenticated-orcid":true,"given":"Egle","family":"Solito","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Department of Medicina Molecolare e Biotecnologie Mediche, University of Naples \u201cFederico II,\u201d Italy (E. Solito)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-3984","authenticated-orcid":true,"given":"Perry","family":"Elliott","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."},{"name":"Institute of Cardiovascular Science, University College London, UK (A.P., P.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7803","authenticated-orcid":true,"given":"Stephane","family":"Heymans","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, the Netherlands (S.H., M.S.)."},{"name":"Department of Cardiovascular Sciences, Centre for Vascular and Molecular Biology, KU Leuven, Belgium (S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8165-6631","authenticated-orcid":true,"given":"Maurits","family":"Sikking","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, the Netherlands (S.H., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Savvatis","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1031-4084","authenticated-orcid":true,"given":"Saidi A.","family":"Mohiddin","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Barts Heart Centre, Barts Health NHS Trust, St Bartholomew\u2019s Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-5823","authenticated-orcid":true,"given":"Federica M.","family":"Marelli-Berg","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK."},{"name":"Centre for Inflammation and Therapeutic Innovation (F.M.M.-B.), Queen Mary University of London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13613"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.12703\/P6-25"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-301121"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2019.20098"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.08.007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006709"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S5900"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02767044"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2005.06.014"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.3.295"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155616.07901.35"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav3487"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85851"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.014"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet588"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.09.014"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000129068.03900.25"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.2008\/000711-0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61685-9"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-020-04900-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60509-0"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2211-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01728-5"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8753"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101212"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2017"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.06.003"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00897-1"},{"key":"e_1_3_3_32_2","first-page":"499","article-title":"Clinical significance and pathogenic role of anti-cardiac myosin autoantibody in dilated cardiomyopathy.","volume":"116","author":"Wang Z","year":"2003","unstructured":"Wang, Z, Liao, Y, Dong, J, Li, S, Wang, J, Fu, ML. Clinical significance and pathogenic role of anti-cardiac myosin autoantibody in dilated cardiomyopathy. Chin Med J (Engl). 2003;116:499\u2013502.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy122"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(99)00172-2"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.937"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044934"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12686"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/12.suppl_d.175"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916930802031546"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1390"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501739"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744075"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1676-0"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.546586"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161702"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5504"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0818-9641.2004.01253.x"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3523"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-014-0230-z"},{"key":"e_1_3_3_50_2","unstructured":"Deleted in proof."},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.11.005"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.012"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601480"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.020"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.04.028"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020428"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)63241-5"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.02.008"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4436"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097326"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408241102"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200203)32:3<606::AID-IMMU606>3.0.CO;2-D"},{"key":"e_1_3_3_63_2","first-page":"603","article-title":"Cytokine gene polymorphisms in childhood dilated cardiomyopathy: interferon-gamma, tumor necrosis factor-alpha and transforming growth factor-beta 1 genes are associated with the disease in Turkish patients.","volume":"23","author":"Balci SO","year":"2013","unstructured":"Balci, SO, Col-Araz, N, Baspinar, O, Sever, T, Balat, A, Pehlivan, S. Cytokine gene polymorphisms in childhood dilated cardiomyopathy: interferon-gamma, tumor necrosis factor-alpha and transforming growth factor-beta 1 genes are associated with the disease in Turkish patients. Iran J Pediatr. 2013;23:603\u2013604.","journal-title":"Iran J Pediatr"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.04.003"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12728"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)80732-2"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.7.1153"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.104.3.275"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.16.1571"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm456"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.007"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.072"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000047527.11221.29"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.033"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740597"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0327-9"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.121.055610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T18:01:03Z","timestamp":1716228063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.121.055610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":76,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2022,12,20]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.121.055610"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.121.055610","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2021-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}