{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:01:12Z","timestamp":1792450872480,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Inflammation is a key factor of myocardial damage in reperfused ST-segment\u2013elevation myocardial infarction. We hypothesized that colchicine, a potent anti-inflammatory agent, may reduce infarct size (IS) and left ventricular (LV) remodeling at the acute phase of ST-segment\u2013elevation myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this double-blind multicenter trial, we randomly assigned patients admitted for a first episode of ST-segment\u2013elevation myocardial infarction referred for primary percutaneous coronary intervention to receive oral colchicine (2-mg loading dose followed by 0.5 mg twice a day) or matching placebo from admission to day 5. The primary efficacy outcome was IS determined by cardiac magnetic resonance imaging at 5 days. The relative LV end-diastolic volume change at 3 months and IS at 3 months assessed by cardiac magnetic resonance imaging were among the secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We enrolled 192 patients, 101 in the colchicine group and 91 in the control group. At 5 days, the gadolinium enhancement\u2013defined IS did not differ between the colchicine and placebo groups with a mean of 26 interquartile range (IQR) [16\u201344] versus 28.4 IQR [14\u201340] g of LV mass, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      =0.87). At 3 months follow-up, there was no significant difference in LV remodeling between the colchicine and placebo groups with a +2.4% (IQR, \u20138.3% to 11.1%) versus \u20131.1% (IQR, \u20138.0% to 9.9%) change in LV end-diastolic volume (\n                      <jats:italic>P<\/jats:italic>\n                      =0.49). Infarct size at 3 months was also not significantly different between the colchicine and placebo groups (17 IQR [10\u201328] versus 18 IQR [10\u201327] g of LV mass, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      =0.92). The incidence of gastrointestinal adverse events during the treatment period was greater with colchicine than with placebo (34% versus 11%, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      =0.0002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this randomized, placebo-controlled trial, oral administration of high-dose colchicine at the time of reperfusion and for 5 days did not reduce IS assessed by cardiac magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03156816.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.121.056177","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T03:00:30Z","timestamp":1629687630000},"page":"859-869","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":172,"title":["Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction"],"prefix":"10.1161","volume":"144","clinical-trial-number":[{"clinical-trial-number":"nct03156816","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-8129","authenticated-orcid":true,"given":"Nathan","family":"Mewton","sequence":"first","affiliation":[{"name":"H\u00f4pital Cardiovasculaire Louis Pradel, Clinical Investigation Center, INSERM 1407 and INSERM CarMeN 1060, Hospices Civils de Lyon and Claude Bernard University, Lyon, France (N.M., C.P., T.B., A.H., F.D., L.H., N.E.J, R.D., C.D.B., G.F., E.B.-C., G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS, Cardiology Department, CHU de Montpellier, France (F.R., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-855X","authenticated-orcid":true,"given":"Didier","family":"Bresson","sequence":"additional","affiliation":[{"name":"Cardiology Division, University Hospital of Mulhouse, H\u00f4pital Emile Muller, Mulhouse, France (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Prieur","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiovasculaire Louis Pradel, Clinical Investigation Center, INSERM 1407 and INSERM CarMeN 1060, Hospices Civils de Lyon and Claude Bernard University, Lyon, France (N.M., C.P., T.B., A.H., F.D., L.H., N.E.J, R.D., C.D.B., G.F., E.B.-C., G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-0093","authenticated-orcid":true,"given":"Claire","family":"Bouleti","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Poitiers, CIC Inserm 1402n CHU de Poitiers, France (C.B., B.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bochaton","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiovasculaire Louis Pradel, Clinical Investigation Center, INSERM 1407 and INSERM CarMeN 1060, Hospices Civils de Lyon and Claude Bernard University, Lyon, France (N.M., C.P., T.B., A.H., F.D., L.H., N.E.J, R.D., C.D.B., G.F., E.B.-C., G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-6387","authenticated-orcid":true,"given":"Fabrice","family":"Ivanes","sequence":"additional","affiliation":[{"name":"Cardiology Department CHRU de Tours and EA4245 T2i Tours University, France (F.I., D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dubreuil","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Saint-Joseph Saint-Luc, Invasive Cardiology Department, Lyon, France (O.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Biere","sequence":"additional","affiliation":[{"name":"Institut MITOVASC, CNRS 6015 INSERM U1083, Universit\u00e9 d\u2019Angers, Cardiology Division, CHU Angers, France (L.B., F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hayek","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiovasculaire Louis Pradel, Clinical Investigation Center, INSERM 1407 and INSERM CarMeN 1060, Hospices Civils de Lyon and Claude Bernard University, Lyon, France (N.M., C.P., T.B., A.H., F.D., L.H., N.E.J, R.D., C.D.B., G.F., E.B.-C., G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-0118","authenticated-orcid":true,"given":"Fran\u00e7ois","family":"Derimay","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiovasculaire Louis Pradel, Clinical Investigation Center, INSERM 1407 and INSERM CarMeN 1060, Hospices Civils de Lyon and Claude Bernard University, Lyon, France (N.M., C.P., T.B., A.H., F.D., L.H., N.E.J, R.D., C.D.B., G.F., E.B.-C., G.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-5655","authenticated-orcid":true,"given":"Mariama","family":"Akodad","sequence":"additional","affiliation":[{"name":"PhyMedExp, Universit\u00e9 de Montpellier, INSERM, CNRS, Cardiology 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