{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:35:11Z","timestamp":1791434111416,"version":"4.3.3"},"reference-count":75,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects occurring in association with ventricular hypoplasia. The pathogenesis of HLHS is unknown, but hemodynamic disturbances are assumed to play a prominent role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>To identify perturbations in gene programs controlling ventricular muscle lineage development in HLHS, we performed whole-exome sequencing of 87 HLHS parent\u2013offspring trios, nuclear transcriptomics of cardiomyocytes from ventricles of 4 patients with HLHS and 15 controls at different stages of heart development, single cell RNA sequencing, and 3D modeling in induced pluripotent stem cells from 3 patients with HLHS and 3 controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Gene set enrichment and protein network analyses of damaging de novo mutations and dysregulated genes from ventricles of patients with HLHS suggested alterations in specific gene programs and cellular processes critical during fetal ventricular cardiogenesis, including cell cycle and cardiomyocyte maturation. Single-cell and 3D modeling with induced pluripotent stem cells demonstrated intrinsic defects in the cell cycle\/unfolded protein response\/autophagy hub resulting in disrupted differentiation of early cardiac progenitor lineages leading to defective cardiomyocyte subtype differentiation\/maturation in HLHS. Premature cell cycle exit of ventricular cardiomyocytes from patients with HLHS prevented normal tissue responses to developmental signals for growth, leading to multinucleation\/polyploidy, accumulation of DNA damage, and exacerbated apoptosis, all potential drivers of left ventricular hypoplasia in absence of hemodynamic cues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results highlight that despite genetic heterogeneity in HLHS, many mutations converge on sequential cellular processes primarily driving cardiac myogenesis, suggesting novel therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.121.056198","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T14:00:27Z","timestamp":1635170427000},"page":"1409-1428","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome"],"prefix":"10.1161","volume":"144","author":[{"given":"Markus","family":"Krane","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Dre\u00dfen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-7492","authenticated-orcid":true,"given":"Gianluca","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"My","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8492-2982","authenticated-orcid":true,"given":"Christine M.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Laue","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Mastantuono","sequence":"additional","affiliation":[{"name":"German Heart Center Munich, and Institute of Human Genetics (E.M., R.B., T.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany (E.M., R.B., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Berutti","sequence":"additional","affiliation":[{"name":"German Heart Center Munich, and Institute of Human Genetics (E.M., R.B., T.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany (E.M., R.B., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilansi","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-1535","authenticated-orcid":true,"given":"Ralf","family":"Gilsbach","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology (R.G., P.S., L.H.), University of Freiburg, Germany."},{"name":"Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany (R.G.)."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site RheinMain, Frankfurt am Main, Germany (R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-7816","authenticated-orcid":true,"given":"Pedro","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology (R.G., P.S., L.H.), University of Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-3406","authenticated-orcid":true,"given":"Harald","family":"Lahm","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Applied Tissue Engineering and Regenerative Medicine (CANTER), Munich University of Applied Sciences, Germany (S. Schwarz, S. Sudhop)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie A.","family":"Doppler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-5957","authenticated-orcid":true,"given":"Sharon","family":"Paige","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Stanford University School of Medicine, CA (S.P., S.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan","family":"Puluca","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Doll","sequence":"additional","affiliation":[{"name":"Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (S.D., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Neb","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brade","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Abou-Ajram","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-3231","authenticated-orcid":true,"given":"Bernd","family":"Northoff","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine (B.N., L.M.H.), University Hospital, LMU Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesca M.","family":"Holdt","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine (B.N., L.M.H.), University Hospital, LMU Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-9503","authenticated-orcid":true,"given":"Stefanie","family":"Sudhop","sequence":"additional","affiliation":[{"name":"Center for Applied Tissue Engineering and Regenerative Medicine (CANTER), Munich University of Applied Sciences, Germany (S. Schwarz, S. Sudhop)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sahara","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Goedel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Dendorfer","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."},{"name":"Walter-Brendel-Centre of Experimental Medicine (A.D.), University Hospital, LMU Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-0081","authenticated-orcid":true,"given":"Fleur V.Y.","family":"Tjong","sequence":"additional","affiliation":[{"name":"Heart Centre, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, The Netherlands (F.V.Y.T., C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Rijlaarsdam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Leiden University Medical Center, The Netherlands (M.E.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-4375","authenticated-orcid":true,"given":"Julie","family":"Cleuziou","sequence":"additional","affiliation":[{"name":"Department of Congenital and Paediatric Heart Surgery, Institute Insure (J.C.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology and Congenital Heart Defects (N.L.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kupatt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-3514","authenticated-orcid":true,"given":"Connie","family":"Bezzina","sequence":"additional","affiliation":[{"name":"Heart Centre, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, The Netherlands (F.V.Y.T., C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Institute Insure (M.K., M.D., H.L., S.A.D., N.P., I.N., Z.Z., C.A.-A., R.L.),Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E.","family":"Bowles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Division of Cardiology), University of Utah School of Medicine, Salt Lake City (N.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mann","sequence":"additional","affiliation":[{"name":"Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (S.D., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-5027","authenticated-orcid":true,"given":"Bruce D.","family":"Gelb","sequence":"additional","affiliation":[{"name":"The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York (B.D.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8739-6527","authenticated-orcid":true,"given":"Lia","family":"Crotti","sequence":"additional","affiliation":[{"name":"Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS, Milan, Italy (L.C.)."},{"name":"Cardiomyopathies Unit, Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Milan, Italy (L.C.)."},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-0007","authenticated-orcid":true,"given":"Lutz","family":"Hein","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology (R.G., P.S., L.H.), University of Freiburg, Germany."},{"name":"BIOSS, Center for Biological Signaling Studies (L.H.), University of Freiburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-8403","authenticated-orcid":true,"given":"Thomas","family":"Meitinger","sequence":"additional","affiliation":[{"name":"German Heart Center Munich, and Institute of Human Genetics (E.M., R.B., T.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."},{"name":"Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany (E.M., R.B., T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-3821","authenticated-orcid":true,"given":"Sean","family":"Wu","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Stanford University School of Medicine, CA (S.P., S.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sinnecker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-905X","authenticated-orcid":true,"given":"Peter J.","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Surgery, Yale University, New Haven, CT (P.J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-4846","authenticated-orcid":true,"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-7832","authenticated-orcid":true,"given":"Alessandra","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology (G.S., I.M., C.M.S., T.D., S.L., E.M., H.R., T.B., A.G., C.K., D.S., K.-L.L., A.M.), Klinikum rechts der Isar, School of Medicine &amp; Health, Technical University of Munich, Germany."},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013partner site Munich Heart Alliance, Germany (M.K., A.D., C.K., R.L., T.M., D.S., K.-L.L., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"61","article-title":"Pathologic anatomy and interrelationship of hypoplasia of the aortic tract complexes.","volume":"1","author":"Lev M","year":"1952","unstructured":"Lev, M. Pathologic anatomy and interrelationship of hypoplasia of the aortic tract complexes. Lab Invest 1952;1:61\u201370.","journal-title":"Lab Invest"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-3955(16)30727-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00500-5"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.021"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.857987"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.046"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(73)90810-2"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0683-4"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd6010010"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3870"},{"key":"e_1_3_4_12_2","article-title":"IPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome.","author":"Xinxiu Xu KJ","unstructured":"Xinxiu Xu, KJ, Bais, AS, Zhu, W, Yagi, H, Feinstein, TN, Nguyen, P, Criscione, J, Liu, X, Beutner, G, Karunakaran, KB, et al. IPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome. BioRxiv. Preprint posted online May 10, 2021. doi: 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