{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:26:03Z","timestamp":1790774763875,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We reviewed the results of endovascular aneurysm repair in patients from the Japanese Committee for Stentgraft Management registry to determine the significance of persistent type II endoleak (p-T2EL) and the risk of late adverse events, including aneurysm sac enlargement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The prospectively captured medical records of 17\u2009099 patients &lt;75 years of age who underwent endovascular aneurysm repair for abdominal aortic aneurysm from 2006 to 2015 were reviewed. Patients were divided into 2 groups (with or without p-T2EL) and compared to examine the correlation between p-T2EL and the occurrence of aneurysm sac enlargement after endovascular aneurysm repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the patients, 4957 (29.0%) had p-T2EL and 12\u2009142 (71.0%) had no p-T2EL (non-T2EL). Mean age was significantly higher (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and there were fewer men (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) in the p-T2EL group. Among comorbidities, hypertension (\n                      <jats:italic>P<\/jats:italic>\n                      =0.019) and chronic kidney disease (\n                      <jats:italic>P<\/jats:italic>\n                      =0.040) were more prevalent and respiratory disorders were less prevalent (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) in the p-T2EL group. From each group, 4957 patients were matched according to propensity score to adjust for differences in patient characteristics. The cumulative incidence rates of abdominal aortic aneurysm\u2013related mortality (p-T2EL: 52 of 4957 [1.0%] versus non-T2EL: 21 of 12\u2009142 [0.2%]), rupture (p-T2EL: 38 of 4957 [0.8%] versus non-T2EL: 13 of 12\u2009142 [0.1%]), sac enlargement (\u22655 mm; p-T2EL: 1359 of 4957 [27.4%] versus non-T2EL: 332 of 12\u2009142 [2.7%]), and reintervention (p-T2EL: 739 of 4957 [14.9%] versus non-T2EL: 91 of 12\u2009142 [0.7%]) were significantly higher in the p-T2EL than the nonpT2EL group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Propensity score matching yielded higher estimated incremental risk, including abdominal aortic aneurysm\u2013related mortality, rupture, sac enlargement (\u22655 mm), and reintervention for p-T2EL (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Cox regression analysis revealed older age (\n                      <jats:italic>P<\/jats:italic>\n                      =0.010), proximal neck diameter (\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), and chronic kidney disease (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) as independent positive predictors and male sex as an independent negative predictor (\n                      <jats:italic>P<\/jats:italic>\n                      =0.015) of sac enlargement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The Japanese Committee for Stentgraft Management registry data show a correlation between p-T2EL and late adverse events, including aneurysm sac enlargement, reintervention, rupture, and abdominal aortic aneurysm\u2013related mortality after endovascular aneurysm repair. Besides p-T2EL, older age, female sex, chronic kidney disease, and dilated proximal neck were associated with sac enlargement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.121.056581","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T05:00:17Z","timestamp":1645765217000},"page":"1056-1066","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":133,"title":["Nationwide Analysis of Persistent Type II Endoleak and Late Outcomes of Endovascular Abdominal Aortic Aneurysm Repair in Japan: A Propensity-Matched Analysis"],"prefix":"10.1161","volume":"145","author":[{"given":"Yoshimasa","family":"Seike","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (Y.S., H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-2391","authenticated-orcid":true,"given":"Hitoshi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (Y.S., H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Keio University, Tokyo, Japan (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Toda Chuo General Hospital, Saitama, Japan (S.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Hoshina","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery (K.H.), University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Michihata","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health (N.M., H.Y.), University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6017-469X","authenticated-orcid":true,"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health (N.M., H.Y.), University of Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiro","family":"Komori","sequence":"additional","affiliation":[{"name":"Divison of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Japan (K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Japanese Committee for Stentgraft Management (JACSM)*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1583\/1074-6218(1998)005<0189:TIATIE>2.0.CO;2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1426"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909305"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.08.087"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574419858824"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2019.03.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.10.044"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.05.062"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.10.078"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X17704315"},{"key":"e_1_3_3_12_2","unstructured":"Japanese Committee for Stentgraft Management. 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