{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:13:32Z","timestamp":1789766012658,"version":"4.0.1"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Understanding the clinical course and short-term outcomes of suspected myocarditis after the coronavirus disease 2019 (COVID-19) vaccination has important public health implications in the decision to vaccinate youth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively collected data on patients &lt;21 years old presenting before July 4, 2021, with suspected myocarditis within 30 days of COVID-19 vaccination. Lake Louise criteria were used for cardiac MRI findings. Myocarditis cases were classified as confirmed or probable on the basis of the Centers for Disease Control and Prevention definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We report on 139 adolescents and young adults with 140 episodes of suspected myocarditis (49 confirmed, 91 probable) at 26 centers. Most patients were male (n=126, 90.6%) and White (n=92, 66.2%); 29 (20.9%) were Hispanic; and the median age was 15.8 years (range, 12.1\u201320.3; interquartile range [IQR], 14.5\u201317.0). Suspected myocarditis occurred in 136 patients (97.8%) after the mRNA vaccine, with 131 (94.2%) after the Pfizer-BioNTech vaccine; 128 (91.4%) occurred after the second dose. Symptoms started at a median of 2 days (range, 0\u201322; IQR, 1\u20133) after vaccination. The most common symptom was chest pain (99.3%). Patients were treated with nonsteroidal anti-inflammatory drugs (81.3%), intravenous immunoglobulin (21.6%), glucocorticoids (21.6%), colchicine (7.9%), or no anti-inflammatory therapies (8.6%). Twenty-six patients (18.7%) were in the intensive care unit, 2 were treated with inotropic\/vasoactive support, and none required extracorporeal membrane oxygenation or died. Median hospital stay was 2 days (range, 0\u201310; IQR, 2\u20133). All patients had elevated troponin I (n=111, 8.12 ng\/mL; IQR, 3.50\u201315.90) or T (n=28, 0.61 ng\/mL; IQR, 0.25\u20131.30); 69.8% had abnormal ECGs and arrhythmias (7 with nonsustained ventricular tachycardia); and 18.7% had left ventricular ejection fraction &lt;55% on echocardiogram. Of 97 patients who underwent cardiac MRI at a median 5 days (range, 0\u201388; IQR, 3\u201317) from symptom onset, 75 (77.3%) had abnormal findings: 74 (76.3%) had late gadolinium enhancement, 54 (55.7%) had myocardial edema, and 49 (50.5%) met Lake Louise criteria. Among 26 patients with left ventricular ejection fraction &lt;55% on echocardiogram, all with follow-up had normalized function (n=25).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Most cases of suspected COVID-19 vaccine myocarditis occurring in persons &lt;21 years have a mild clinical course with rapid resolution of symptoms. Abnormal findings on cardiac MRI were frequent. Future studies should evaluate risk factors, mechanisms, and long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.121.056583","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T05:03:16Z","timestamp":1638766996000},"page":"345-356","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":160,"title":["Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination"],"prefix":"10.1161","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-6061","authenticated-orcid":true,"given":"Dongngan T.","family":"Truong","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, University of Utah and Primary Children\u2019s Hospital, Salt Lake City (D.T.T., L.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2864-1830","authenticated-orcid":true,"given":"Audrey","family":"Dionne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Department of Pediatrics; Harvard Medical School, MA (A.D., J.W.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Muniz","sequence":"additional","affiliation":[{"name":"Nicklaus Children\u2019s Hospital, Miami, FL (J.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly E.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical University of South Carolina, Charleston (K.E.M., A.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Portman","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s, Department of Pediatrics, University of Washington (M.A.P., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, University of Utah and Primary Children\u2019s Hospital, Salt Lake City (D.T.T., L.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Thacker","sequence":"additional","affiliation":[{"name":"Nemours Cardiac Center, Nemours Children\u2019s Health, Wilmington, DE (D.T., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-2809","authenticated-orcid":true,"given":"Matthew D.","family":"Elias","sequence":"additional","affiliation":[{"name":"Division of Cardiology, The Children\u2019s Hospital of Philadelphia, PA (M.D.E., T.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Li","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, NC (J.S.L., M.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga H.","family":"Toro-Salazar","sequence":"additional","affiliation":[{"name":"Connecticut Children's Medical Center and University of Connecticut School of Medicine, Farmington (O.H.T.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett R.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology; NewYork-Presbyterian\/Columbia University Irving Medical Center (B.R.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Atz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical University of South Carolina, Charleston (K.E.M., A.M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-5392","authenticated-orcid":true,"given":"C. 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