{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:32:48Z","timestamp":1792031568459,"version":"4.4.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The present analysis was based on the ongoing, prospective, multicenter ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) trial registry in China. Our analytic sample comprised 2134 patients recruited at 48 sites between 2017 and 2021 and included 462 patients who received BMM and 1672 patients who received EVT. We performed an inversed probability of treatment weighting analysis. Qualifying patients had to present within 24 hours of estimated BAO. The primary clinical outcome was favorable functional outcome (modified Rankin Scale score, 0\u20133) at 90 days. We also performed a sensitivity analysis with the propensity score matching\u2013based and the instrumental variable\u2013based analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In our primary analysis using the inversed probability of treatment weighting\u2013based analysis, there was a significantly higher rate of favorable outcome at 90 days among EVT patients compared with BMM-treated patients (adjusted relative risk, 1.42 [95% CI, 1.19\u20131.65]; absolute risk difference, 11.8% [95% CI, 6.9\u201316.7]). The mortality was significantly lower (adjusted relative risk, 0.78 [95% CI, 0.69\u20130.88]; absolute risk difference, \u221210.3% [95% CI, \u221215.8 to \u22124.9]) in patients undergoing EVT. Results were generally consistent across the secondary end points. Similar associations were seen in the propensity score matching\u2013based and instrumental variable\u2013based analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this real-world study, EVT was associated with significantly better functional outcomes and survival at 90 days. Well-designed randomized studies comparing EVT with BMM in the acute BAO are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"www.chictr.org.cn\">www.chictr.org.cn<\/jats:ext-link>\n                      ; Unique identifier: ChiCTR2000041117.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.121.058544","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T14:02:34Z","timestamp":1657029754000},"page":"6-17","source":"Crossref","is-referenced-by-count":99,"title":["Endovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry"],"prefix":"10.1161","volume":"146","author":[{"given":"Chunrong","family":"Tao","sequence":"first","affiliation":[{"name":"Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-540X","authenticated-orcid":true,"given":"Adnan I.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Zeenat Qureshi Stroke Research Center, University of Minnesota, Minneapolis (A.I.Q.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Yin","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei Anhui, 230001, China (C.T., Y.Y., J.L., R.L., P.X., J.Sun, W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Maoming People\u2019s Hospital, Guangdong, China (G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincan","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhoukou Central Hospital, China (X.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing First Hospital, China (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurovascular Intervention, Cangzhou Central Hospital, China (Yongchang Liu)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Suzhou Municipal Hospital, China (Z.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-7016","authenticated-orcid":true,"given":"Jinhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (J.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, China (G.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Qingdao Central Hospital, Qingdao University, China (B.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou First People\u2019s Hospital, China (C.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Jingzhou Central Hospital, China 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(H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, China (W.Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fujian Provincial Hospital, Fuzhou, China (Y.Li)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China (D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China (C.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Emergency, Xiangtan Central Hospital, China (G.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Liangxiang Hospital, Fangshan District, Beijing, China (C.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Karamay Central Hospital, China (W.Liang)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Kunming Medical University, China (Chun Chen)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Anqing Hospital Affiliated to Anhui Medical University, China (X.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Wan-bei Coal and Electricity Group, The Third Hospital Affiliated of Bengbu Medical College, Suzhou, China (J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, General Hospital of Wan-bei Coal and Electricity Group, The Third Hospital Affiliated of Bengbu Medical College, Suzhou, China (J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Lishui 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Endovascular treatment for acute basilar artery occlusion - a multicenter randomized controlled trial (ATTENTION) [published online February 22, 2022]. Int J Stroke. doi: 10.1177\/17474930221077164. https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930221077164","journal-title":"Int J Stroke"},{"key":"e_1_3_3_44_2","article-title":"Basilar Artery Occlusion Chinese Endovascular Trial (BAOCHE): protocol for a prospective randomized controlled study [published online August 28, 2021].","author":"Li C","unstructured":"Li, C, Wu, C, Wu, L, Zhao, W, Chen, J, Ren, M, Yao, C, Yan, X, Dong, C, Song, H, et al. Basilar Artery Occlusion Chinese Endovascular Trial (BAOCHE): protocol for a prospective randomized controlled study [published online August 28, 2021]. 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