{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:44:09Z","timestamp":1791999849499,"version":"4.4.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2023,4,25]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Managing disease risk among first-degree relatives of probands diagnosed with a heritable disease is central to precision medicine. A critical component is often clinical screening, which is particularly important for conditions like dilated cardiomyopathy (DCM) that remain asymptomatic until severe disease develops. Nonetheless, probands are frequently ill-equipped to disseminate genetic risk information that motivates at-risk relatives to complete recommended clinical screening. An easily implemented remedy for this key issue has been elusive.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              The DCM Precision Medicine Study developed\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              , a booklet designed to help probands with DCM communicate genetic risk and the need for cardiovascular screening to their relatives. The effectiveness of the\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              booklet in increasing cardiovascular clinical screening uptake among first-degree relatives was assessed in a multicenter, open-label, cluster-randomized, controlled trial. The primary outcome measured in eligible first-degree relatives was completion of screening initiated within 12 months after proband enrollment. Because probands randomized to the intervention received the booklet at the enrollment visit, eligible first-degree relatives were limited to those who were alive the day after proband enrollment and not enrolled on the same day as the proband.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Between June 2016 and March 2020, 1241 probands were randomized (1:1) to receive\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              (n=621) or not (n=620) within strata defined by site and self-identified race\/ethnicity (non-Hispanic Black, non-Hispanic White, or Hispanic). Final analyses included 550 families (n=2230 eligible first-degree relatives) in the\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              arm and 561 (n=2416) in the control arm. A higher percentage of eligible first-degree relatives completed screening in the\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              arm (19.5% versus 16.0%), and the odds of screening completion among these first-degree relatives were higher in the\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              arm after adjustment for proband randomization stratum, sex, and age quartile (odds ratio, 1.30 [1-sided 95% CI, 1.08\u2013\u221e]). A prespecified subgroup analysis did not find evidence of heterogeneity in the adjusted intervention odds ratio across race\/ethnicity strata (\n              <jats:italic>P<\/jats:italic>\n              =0.90).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              <jats:italic>Family Heart Talk<\/jats:italic>\n              , a booklet that can be provided to patients with DCM by clinicians with minimal additional time investment, was effective in increasing cardiovascular clinical screening among first-degree relatives of these patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03037632.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.122.062507","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T18:00:48Z","timestamp":1682359248000},"page":"1281-1290","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of the\n            <i>Family Heart Talk<\/i>\n            Communication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial"],"prefix":"10.1161","volume":"147","clinical-trial-number":[{"clinical-trial-number":"nct03037632","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-5227","authenticated-orcid":true,"given":"Daniel D.","family":"Kinnamon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus."},{"name":"the Davis Heart and Lung Research Institute (D.D.K., E.J., G.J.H., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-3258","authenticated-orcid":true,"given":"Elizabeth","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Human Genetics (D.D.K., E.J., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus."},{"name":"the Davis Heart and Lung Research Institute (D.D.K., E.J., G.J.H., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrie J.","family":"Haas","sequence":"additional","affiliation":[{"name":"the Davis Heart and Lung Research Institute (D.D.K., E.J., G.J.H., J.O.M., H.N., R.E.H.), The Ohio State University, Columbus."},{"name":"Department of Internal Medicine, Division of Cardiovascular Medicine (G.J.H., R.E.H.), The Ohio State University, Columbus."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hofmeyer","sequence":"additional","affiliation":[{"name":"Medstar Research Institute, Washington Hospital Center, DC (M.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-2412","authenticated-orcid":true,"given":"Evan","family":"Kransdorf","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Ewald","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO (G.A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8033-3707","authenticated-orcid":true,"given":"Alanna A.","family":"Morris","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA (A.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-8495","authenticated-orcid":true,"given":"Anjali","family":"Owens","sequence":"additional","affiliation":[{"name":"Center for Inherited Cardiovascular Disease, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia (A.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-2540","authenticated-orcid":true,"given":"Brian","family":"Lowes","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha (B.L., D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Stoller","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha (B.L., D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":true,"given":"W.H. 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