{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:01Z","timestamp":1792787581299,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","funder":[{"DOI":"10.13039\/501100016983","name":"Shanghai Clinical Research Center","doi-asserted-by":"crossref","award":["19MC1910300"],"award-info":[{"award-number":["19MC1910300"]}],"id":[{"id":"10.13039\/501100016983","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010108","name":"Zhongshan Hospital","doi-asserted-by":"crossref","award":["2020ZSLC57"],"award-info":[{"award-number":["2020ZSLC57"]}],"id":[{"id":"10.13039\/501100010108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hangzhou Zhongmei Huadong Pharmaceutical Company"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2023,1,17]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Dual antiplatelet therapy (DAPT) with aspirin as a background therapy has become the standard care after percutaneous coronary intervention. However, some adverse noncardiac effects limited the use of aspirin in clinical practice. Thus, evaluation of pharmacological alternatives to aspirin is attractive. Previous data indicated that indobufen could lessen the unwanted side effects of aspirin while retaining the antithrombotic efficacy, but its combination with a P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitor still lacks randomized clinical trial evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this randomized, open-label, noninferiority trial, patients with negative cardiac troponin undergoing coronary drug-eluting stent implantation were randomly assigned in a 1:1 ratio to receive either indobufen-based DAPT (indobufen 100 mg twice a day plus clopidogrel 75 mg\/d for 12 months) or conventional DAPT (aspirin 100 mg\/d plus clopidogrel 75 mg\/d for 12 months). The primary end point was a 1-year composite of cardiovascular death, nonfatal myocardial infarction, ischemic stroke, definite or probable stent thrombosis, or Bleeding Academic Research Consortium criteria type 2, 3, or 5 bleeding. The end points were adjudicated by an independent Clinical Event Committee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Between January 11, 2018, and October 12, 2020, 4551 patients were randomized in 103 cardiovascular centers: 2258 patients to the indobufen-based DAPT group and 2293 to the conventional DAPT group. The primary end point occurred in 101 patients (4.47%) in the indobufen-based DAPT group and 140 patients (6.11%) in the conventional DAPT group (absolute difference, \u22121.63%;\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>noninferiority<\/jats:sub>\n                      &lt;0.001; hazard ratio, 0.73 [95% CI, 0.56\u20130.94];\n                      <jats:italic>P<\/jats:italic>\n                      =0.015). Cardiovascular death, nonfatal myocardial infarction, ischemic stroke, and stent thrombosis were observed in 0.13%, 0.40%, 0.80%, and 0.22% of patients in the indobufen-based DAPT group and 0.17%, 0.44%, 0.83%, and 0.17% of patients in the conventional DAPT group (all\n                      <jats:italic>P<\/jats:italic>\n                      &gt;0.05). The occurrence of Bleeding Academic Research Consortium criteria type 2, 3, or 5 bleeding events was lower in the indobufen-based DAPT group compared with the conventional DAPT group (2.97% versus 4.71%; hazard ratio, 0.63 [95% CI, 0.46\u20130.85];\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), with the main decrease in type 2 bleeding (1.68% versus 3.49%; hazard ratio, 0.48 [95% CI, 0.33\u20130.70];\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In Chinese patients with negative cardiac troponin undergoing drug-eluting stent implantation, indobufen plus clopidogrel DAPT compared with aspirin plus clopidogrel DAPT significantly reduced the risk of 1-year net clinical outcomes, which was driven mainly by a reduction in bleeding events without an increase in ischemic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\">https:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      ; Unique identifier: ChiCTR-IIR-17013505.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.122.062762","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T18:13:42Z","timestamp":1667758422000},"page":"212-222","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Indobufen or Aspirin on Top of Clopidogrel After Coronary Drug-Eluting Stent Implantation (OPTION): A Randomized, Open-Label, End Point\u2013Blinded, Noninferiority Trial"],"prefix":"10.1161","volume":"147","author":[{"given":"Hongyi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Taian City Central Hospital, Shandong, China (H.Y.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Xi\u2019an No. 3 Hospital, Affiliated Hospital of Northwest University, Xi\u2019an, Shanxi, China (K.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China (X.Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Central Hospital of Wuhan, Hubei, China (M.H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Hospital of Tianjin Medical University, China (G.P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangnan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, China (J.N.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dongguan Third People\u2019s Hospital, Guangdong, China (J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghe","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Jining Medical University, Shandong, China (G.H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinman","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-3692","authenticated-orcid":true,"given":"Juying","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-7332","authenticated-orcid":true,"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, China (H.Y.W., L.L.X., X.Z., C.Z., Y.M.W., J.Y.Q., J.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the OPTION 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Society of Cardiology and Chinese College of Cardiovascular Physicians expert consensus statement on dual antiplatelet therapy in patients with coronary artery disease [in Chinese].","volume":"49","author":"Atherosclerosis and Coronary Heart Disease Working Group of Chinese Society of Cardiology; Interventional Cardiology Working Group of Chinese Society of Cardiology, Specialty Committee on Prevention and Treatment of Thrombosis of Chinese College of Cardiovascular Physicians, Specialty Committee on Coronary Artery Disease and Atherosclerosis of Chinese College of Cardiovascular Physicians, Editorial Board of Chinese Journal of Cardiology","year":"2021","unstructured":"Atherosclerosis and Coronary Heart Disease Working Group of Chinese Society of Cardiology; Interventional Cardiology Working Group of Chinese Society of Cardiology, Specialty Committee on Prevention and Treatment of Thrombosis of Chinese College of Cardiovascular Physicians, Specialty Committee on Coronary Artery Disease and Atherosclerosis of Chinese College of Cardiovascular Physicians, Editorial Board of Chinese Journal of Cardiology. Chinese Society of Cardiology and Chinese College of Cardiovascular Physicians expert consensus statement on dual antiplatelet therapy in patients with coronary artery disease [in Chinese]. Chin J Cardiol. 2021;49:432\u2013454.","journal-title":"Chin J Cardiol"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.122.062762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T15:19:01Z","timestamp":1677770341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.122.062762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,1,17]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.122.062762"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.122.062762","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]},"assertion":[{"value":"2022-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}