{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:37Z","timestamp":1787018077582,"version":"build-2736575974"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["201509-FDN-353640"],"award-info":[{"award-number":["201509-FDN-353640"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Calgary, Clinical Research Fund"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Self-management education and support (SMES) interventions have modest effects on intermediate outcomes for those at risk of cardiovascular disease, but few studies have measured or demonstrated an effect on clinical end points. Advertising for commercial products is known to influence behavior, but advertising principles are not typically incorporated into SMES design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This randomized trial studied the effect of a novel tailored SMES program designed by an advertising firm among a population of older adults with low income at high cardiovascular risk in Alberta, Canada. The intervention included health promotion messaging from a fictitious \u201cpeer\u201d and facilitated relay of clinical information to patients\u2019 primary care provider and pharmacist. The primary outcome was the composite of death, myocardial infarction, stroke, coronary revascularization, and hospitalizations for cardiovascular-related ambulatory care\u2013sensitive conditions. Rates of the primary outcome and its components were compared using negative binomial regression. Secondary outcomes included quality of life (EQ-5D [EuroQoL 5-dimension] index score), medication adherence, and overall health care costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We randomized 4761 individuals, with a mean age of 74.4 years, of whom 46.8% were female. There was no evidence of statistical interaction (\n                      <jats:italic>P<\/jats:italic>\n                      =0.99) or of a synergistic effect between the 2 interventions in the factorial trial with respect to the primary outcome, which allowed us to evaluate the effect of each intervention separately. Over a median follow-up time of 36 months, the rate of the primary outcome was lower in the group that received SMES compared with the control group (incidence rate ratio, 0.78 [95% CI, 0.61 to 1.00];\n                      <jats:italic>P<\/jats:italic>\n                      =0.047). No significant between-group changes in quality of life over time were observed (mean difference, 0.0001 [95% CI, \u22120.018 to 0.018];\n                      <jats:italic>P<\/jats:italic>\n                      =0.99). The proportion of participants who were adherent to medications was not different between the 2 groups (\n                      <jats:italic>P<\/jats:italic>\n                      =0.199 for statins and\n                      <jats:italic>P<\/jats:italic>\n                      =0.754 for angiotensin-converting enzyme inhibitors\/angiotensin receptor blockers). Overall adjusted health care costs did not differ between those receiving SMES and the control group ($2015 [95% CI, \u2212$1953 to $5985];\n                      <jats:italic>P<\/jats:italic>\n                      =0.320).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>For older adults with low income, a tailored SMES program using advertising principles reduced the rate of clinical outcomes compared with usual care. The mechanisms of improvement are unclear and further studies are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02579655.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.123.064189","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T10:46:15Z","timestamp":1678013175000},"page":"1492-1504","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Self-Management Support Using Advertising Principles for Older Adults With Low Income at High Cardiovascular Risk: A Randomized Controlled Trial"],"prefix":"10.1161","volume":"147","clinical-trial-number":[{"clinical-trial-number":"nct02579655","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-3630","authenticated-orcid":true,"given":"David J.T.","family":"Campbell","sequence":"first","affiliation":[{"name":"Departments of Community Health Sciences (D.J.T.C., M.T., P.F., J.Z., F.A., J.F., D.V.E., B.J.M.), University of Calgary, Alberta, Canada."},{"name":"Medicine (D.J.T.C., M.T., B.J.M.), University of Calgary, Alberta, Canada."},{"name":"Cardiac Sciences (D.J.T.C., D.V.E.), University of Calgary, Alberta, Canada."},{"name":"Cumming School of Medicine, O\u2019Brien Institute for Public Health (D.J.T.C., M.T., D.V.E., B.J.M.), University of Calgary, Alberta, Canada."},{"name":"Libin Cardiovascular Institute (D.J.T.C., M.T., D.V.E., B.J.M.), University of Calgary, Alberta, 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