{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:33Z","timestamp":1791837513829,"version":"4.3.4"},"reference-count":83,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implicated in preeclampsia, but the mechanistic link remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              Single-cell RNA sequencing and spatial transcriptomics were used to identify immune cell subsets associated with preeclampsia. Cell-based studies and animal models including conditional knockout mice and a new preeclampsia mouse model induced by recombinant mouse galectin-9 were applied to validate the pathogenic role of a CD11c\n              <jats:sup>high<\/jats:sup>\n              subpopulation of decidual macrophages (dM\u03c6) and to determine its underlying regulatory mechanisms in preeclampsia. A retrospective preeclampsia cohort study was performed to determine the value of circulating galectin-9 in predicting preeclampsia.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              We discovered a distinct CD11c\n              <jats:sup>high<\/jats:sup>\n              dM\u03c6 subset that inhibits spiral artery remodeling in preeclampsia. The proinflammatory CD11c\n              <jats:sup>high<\/jats:sup>\n              dM\u03c6 exhibits perivascular enrichment in the decidua from patients with preeclampsia. We also showed that trophoblast-derived galectin-9 activates CD11c\n              <jats:sup>high<\/jats:sup>\n              dM\u03c6 by means of CD44 binding to suppress spiral artery remodeling. In 3 independent preeclampsia mouse models, placental and plasma galectin-9 levels were elevated. Galectin-9 administration in mice induces preeclampsia-like phenotypes with increased CD11c\n              <jats:sup>high<\/jats:sup>\n              dM\u03c6 and defective spiral arteries, whereas galectin-9 blockade or macrophage-specific CD44 deletion prevents such phenotypes. In pregnant women, increased circulating galectin-9 levels in the first trimester and at 16 to 20 gestational weeks can predict subsequent preeclampsia onset.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>\n              These findings highlight a key role of a distinct perivascular inflammatory CD11c\n              <jats:sup>high<\/jats:sup>\n              dM\u03c6 subpopulation in the pathogenesis of preeclampsia. CD11c\n              <jats:sup>high<\/jats:sup>\n              dM\u03c6 activated by increased galectin-9 from trophoblasts suppresses uterine spiral artery remodeling, contributing to preeclampsia. Increased circulating galectin-9 may be a biomarker for preeclampsia prediction and intervention.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.123.064391","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T10:00:41Z","timestamp":1707127241000},"page":"1670-1688","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["A Galectin-9\u2013Driven CD11c\n            <sup>high<\/sup>\n            Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia"],"prefix":"10.1161","volume":"149","author":[{"given":"Yanhong","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, China (Y. Li, Y.S., C.X., Y. Lin, L.X., J.C., W.Z., L.L., D.L., M.D.)."},{"name":"Department of Obstetrics, Longgang District Maternity and Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Clinical Institute of Shantou University Medical College), Shenzhen, Guangdong, China (Y. Li, Y. Lin, W.Z., J. Yang, M.D.)."},{"name":"Department of Obstetrics and Gynecology, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University Shanghai, China (Y. Li, M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Sang","sequence":"additional","affiliation":[{"name":"Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, China (Y. Li, Y.S., C.X., Y. Lin, L.X., J.C., W.Z., L.L., D.L., M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-7159","authenticated-orcid":true,"given":"Yunjian","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China (Y.C., Y.Z., H.Z., L.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, China (Y. Li, Y.S., C.X., Y. Lin, L.X., J.C., W.Z., L.L., D.L., M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikong","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, China (Y. Li, Y.S., C.X., Y. Lin, L.X., J.C., W.Z., L.L., D.L., M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6201-2109","authenticated-orcid":true,"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China (Y.C., Y.Z., H.Z., L.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.N.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, China (P.C.N.C., W.S.B.Y.)."},{"name":"The University of Hong Kong Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital, Shenzhen, China (P.C.N.C., W.S.B.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-0879","authenticated-orcid":true,"given":"William S.B.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, LKS Faculty of Medicine, The University of Hong Kong, China (P.C.N.C., W.S.B.Y.)."},{"name":"The University of Hong Kong Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong\u2013Shenzhen Hospital, Shenzhen, China (P.C.N.C., W.S.B.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China (Y.C., Y.Z., H.Z., L.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-5844","authenticated-orcid":true,"given":"Ningzheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Cyrus Tang Hematology Center, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China (N.D., Q.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, China (Y. 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