{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:54:27Z","timestamp":1788191667954,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2023,9,19]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Previous studies comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel coronary disease not involving the left main have shown significantly lower rates of death, myocardial infarction (MI), or stroke after CABG. These studies did not routinely use current-generation drug-eluting stents or fractional flow reserve (FFR) to guide PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>FAME 3 (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) is an investigator-initiated, multicenter, international, randomized trial involving patients with 3-vessel coronary artery disease (not involving the left main coronary artery) in 48 centers worldwide. Patients were randomly assigned to receive FFR-guided PCI using zotarolimus drug-eluting stents or CABG. The prespecified key secondary end point of the trial reported here is the 3-year incidence of the composite of death, MI, or stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 1500 patients were randomized to FFR-guided PCI or CABG. Follow-up was achieved in &gt;96% of patients in both groups. There was no difference in the incidence of the composite of death, MI, or stroke after FFR-guided PCI compared with CABG (12.0% versus 9.2%; hazard ratio [HR], 1.3 [95% CI, 0.98\u20131.83];\n                      <jats:italic>P<\/jats:italic>\n                      =0.07). The rates of death (4.1% versus 3.9%; HR, 1.0 [95% CI, 0.6\u20131.7];\n                      <jats:italic>P<\/jats:italic>\n                      =0.88) and stroke (1.6% versus 2.0%; HR, 0.8 [95% CI, 0.4\u20131.7];\n                      <jats:italic>P<\/jats:italic>\n                      =0.56) were not different. MI occurred more frequently after PCI (7.0% versus 4.2%; HR, 1.7 [95% CI, 1.1\u20132.7];\n                      <jats:italic>P<\/jats:italic>\n                      =0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>At 3-year follow-up, there was no difference in the incidence of the composite of death, MI, or stroke after FFR-guided PCI with current-generation drug-eluting stents compared with CABG. There was a higher incidence of MI after PCI compared with CABG, with no difference in death or stroke. These results provide contemporary data to allow improved shared decision-making between physicians and patients with 3-vessel coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02100722.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.123.065770","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T05:00:39Z","timestamp":1692594039000},"page":"950-958","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Fractional Flow Reserve\u2013Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial"],"prefix":"10.1161","volume":"148","clinical-trial-number":[{"clinical-trial-number":"nct02100722","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Frederik M.","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Catharina Hospital, Eindhoven, the Netherlands (F.M.Z., N.H.J.P., A.H.M.v.S., P.A.L.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-9051","authenticated-orcid":true,"given":"Victoria Y.","family":"Ding","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit (V.Y.D., M.D.), Stanford University, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico H.J.","family":"Pijls","sequence":"additional","affiliation":[{"name":"Catharina Hospital, Eindhoven, the Netherlands (F.M.Z., N.H.J.P., A.H.M.v.S., P.A.L.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-1267","authenticated-orcid":true,"given":"Zsolt","family":"Piroth","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, Hungary (Z.P., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6847-6990","authenticated-orcid":true,"given":"Albert H.M.","family":"van Straten","sequence":"additional","affiliation":[{"name":"Catharina Hospital, Eindhoven, the Netherlands (F.M.Z., N.H.J.P., A.H.M.v.S., P.A.L.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-4970","authenticated-orcid":true,"given":"Laszlo","family":"Szekely","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, Hungary (Z.P., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedrius","family":"Davidavicius","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Vilnius University, Lithuania (G.D., G.K.)."},{"name":"Vilnius University Hospital Santaros Klinikos, Lithuania (G.D., G.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gintaras","family":"Kalinauskas","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Vilnius University, Lithuania (G.D., G.K.)."},{"name":"Vilnius University Hospital Santaros Klinikos, Lithuania (G.D., G.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Mansour","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Canada (S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-2395","authenticated-orcid":true,"given":"Rajesh","family":"Kharbanda","sequence":"additional","affiliation":[{"name":"Oxford University Hospital NHS Trust, UK (R.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"\u00d6stlund-Papadogeorgos","sequence":"additional","affiliation":[{"name":"Danderyd University Hospital and Karolinska Institutet, Solna, Sweden (N.\u00d6.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4667-9181","authenticated-orcid":true,"given":"Adel","family":"Aminian","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Charleroi, Belgium (A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-3463","authenticated-orcid":true,"given":"Keith G.","family":"Oldroyd","sequence":"additional","affiliation":[{"name":"Golden Jubilee National Hospital, Glasgow, UK (K.G.O., N.A.-A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawwar","family":"Al-Attar","sequence":"additional","affiliation":[{"name":"Golden Jubilee National Hospital, Glasgow, UK (K.G.O., N.A.-A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Jagic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Centre Zemun, University of Belgrade, Serbia (N.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Henk E.","family":"Dambrink","sequence":"additional","affiliation":[{"name":"Isala Hospital, Zwolle, the Netherlands (J.-H.E.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-9065","authenticated-orcid":true,"given":"Petr","family":"Kala","sequence":"additional","affiliation":[{"name":"Medical Faculty of Masaryk University and University Hospital Brno, Czech Republic (P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Angeras","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital, Sweden (O.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"MacCarthy","sequence":"additional","affiliation":[{"name":"Kings College Hospital, London, UK (P.M., O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Wendler","sequence":"additional","affiliation":[{"name":"Kings College Hospital, London, UK (P.M., O.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2983-4215","authenticated-orcid":true,"given":"Filip","family":"Casselman","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, Belgium (F.C., B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Witt","sequence":"additional","affiliation":[{"name":"S\u00f6dersjukhuset Hospital, Stockholm, Sweden (N.W.)."},{"name":"Karolinska Institutet, Solna, Sweden (N.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-1662","authenticated-orcid":true,"given":"Kreton","family":"Mavromatis","sequence":"additional","affiliation":[{"name":"Atlanta VA Healthcare System, Decatur, GA (K.M.)."},{"name":"Emory University School of Medicine, Atlanta, GA (K.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-3545","authenticated-orcid":true,"given":"Steven E.S.","family":"Miner","sequence":"additional","affiliation":[{"name":"Southlake Regional Health Centre, Newmarket, Canada (S.E.S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydeep","family":"Sarma","sequence":"additional","affiliation":[{"name":"Wythenshawe Hospital, Manchester, UK (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Engstr\u00f8m","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen, Denmark (T.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-4862","authenticated-orcid":true,"given":"Evald H.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital, Denmark (E.H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A.L.","family":"Tonino","sequence":"additional","affiliation":[{"name":"Catharina Hospital, Eindhoven, the Netherlands (F.M.Z., N.H.J.P., A.H.M.v.S., P.A.L.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-6132","authenticated-orcid":true,"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[{"name":"Houston Methodist Hospital, TX (M.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Stanford Cardiovascular Institute (H.O., A.C.Y., W.F.F.), Stanford University, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-232X","authenticated-orcid":true,"given":"Yuhei","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"New York Presbyterian Brooklyn Methodist and Weill Cornell Medical College (Y.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4686-9441","authenticated-orcid":true,"given":"Mark A.","family":"Hlatky","sequence":"additional","affiliation":[{"name":"Departments of Health Policy and Medicine (M.A.H.), Stanford University, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-2148","authenticated-orcid":true,"given":"Kenneth W.","family":"Mahaffey","sequence":"additional","affiliation":[{"name":"Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, CA (K.W.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-2651","authenticated-orcid":true,"given":"Manisha","family":"Desai","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit (V.Y.D., M.D.), Stanford University, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-492X","authenticated-orcid":true,"given":"Y. Joseph","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery (Y.J.W.), Stanford University, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Stanford Cardiovascular Institute (H.O., A.C.Y., W.F.F.), Stanford University, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-168X","authenticated-orcid":true,"given":"Bernard","family":"De Bruyne","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, Belgium (F.C., B.D.)."},{"name":"Lausanne University Centre Hospital, Switzerland (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-1368","authenticated-orcid":true,"given":"William F.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Stanford Cardiovascular Institute (H.O., A.C.Y., W.F.F.), Stanford University, CA."},{"name":"VA Palo Alto Health Care System, CA (W.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the FAME 3 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804626"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211585"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415447"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.005"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408758"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803538"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2112299"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.06.024"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.04.012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826e1058"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1038"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.720"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.020"},{"key":"e_1_3_3_16_2","unstructured":"R Foundation for Statistical Computing. R: A language and environment for statistical computing. Published 2022. https:\/\/www.R-project.org"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr213"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.012"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31357-5"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.053"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.060049"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.047"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac019"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.10.041"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2216607"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1908419"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.123.065770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:35:09Z","timestamp":1715571309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.123.065770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,9,19]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.123.065770"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.123.065770","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]},"assertion":[{"value":"2023-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}