{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:58:32Z","timestamp":1791647912102,"version":"4.3.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","funder":[{"name":"Cardiovascular Research Foundation"},{"name":"Abbott | Abbott Vascular"},{"name":"Medtronic"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Intravascular imaging\u2013guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared with angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding clinical outcomes is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients with significant coronary artery lesions undergoing PCI in a 1:1 ratio to undergo either an OCT-guided or IVUS-guided PCI. The primary end point was a composite of death from cardiac causes, target vessel\u2013related myocardial infarction, or ischemia-driven target-vessel revascularization at 1 year, which was powered for noninferiority of the OCT group compared with the IVUS group. Safety outcomes were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      At 1 year, primary end point events occurred in 25 of 1005 patients (Kaplan-Meier estimate, 2.5%) in the OCT group and in 31 of 1003 patients (Kaplan-Meier estimate, 3.1%) in the IVUS group (absolute difference, \u22120.6 percentage points; upper boundary of one-sided 97.5% CI, 0.97 percentage points;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001 for noninferiority). The incidence of contrast-induced nephropathy was similar (14 patients [1.4%] in the OCT group versus 15 patients [1.5%] in the IVUS group;\n                      <jats:italic>P<\/jats:italic>\n                      =0.85). The incidence of major procedural complications was lower in the OCT group than in the IVUS group (22 [2.2%] versus 37 [3.7%];\n                      <jats:italic>P<\/jats:italic>\n                      =0.047), although imaging procedure-related complications were not observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with significant coronary artery lesions, OCT-guided PCI was noninferior to IVUS-guided PCI with respect to the incidence of a composite of death from cardiac causes, target vessel\u2013related myocardial infarction, or ischemia-driven target-vessel revascularization at 1 year. The selected study population and lower-than-expected event rates should be considered in interpreting the trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique number: NCT03394079.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.123.066429","type":"journal-article","created":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T03:14:07Z","timestamp":1693106047000},"page":"1195-1206","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":174,"title":["Optical Coherence Tomography\u2013Guided or Intravascular Ultrasound\u2013Guided Percutaneous Coronary Intervention: The OCTIVUS Randomized Clinical Trial"],"prefix":"10.1161","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-0562","authenticated-orcid":true,"given":"Do-Yoon","family":"Kang","sequence":"first","affiliation":[{"name":"Division of Cardiology (D.-Y.K., J.-M.A., H.K., Y.C., J.L., D.-W.P., S.-J.P.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4031-391X","authenticated-orcid":true,"given":"Jung-Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology (D.-Y.K., J.-M.A., H.K., Y.C., J.L., D.-W.P., S.-J.P.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Cheol","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Biostatistics (S.-C.Y.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ho","family":"Hur","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Keimyung University Dongsan Hospital, Daegu, Korea (S.-H.H., Y.-K.C., C.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Kyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Keimyung University Dongsan Hospital, Daegu, Korea (S.-H.H., Y.-K.C., C.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Keimyung University Dongsan Hospital, Daegu, Korea (S.-H.H., Y.-K.C., C.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-6678","authenticated-orcid":true,"given":"Soon Jun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea (S.J.H., S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4660-8911","authenticated-orcid":true,"given":"Subin","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea (S.J.H., S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-8596","authenticated-orcid":true,"given":"Sang-Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Korea (S.-W.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-3477","authenticated-orcid":true,"given":"Hoyoun","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea (H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5775-5821","authenticated-orcid":true,"given":"Jun-Hyok","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Medical Research Institute, Pusan National University Hospital, Korea (J.-H.O., J.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Cheon","family":"Choe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Medical Research Institute, Pusan National University Hospital, Korea (J.-H.O., 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Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-2589","authenticated-orcid":true,"given":"Yeonwoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology (D.-Y.K., J.-M.A., H.K., Y.C., J.L., D.-W.P., S.-J.P.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3946-3478","authenticated-orcid":true,"given":"Jinho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology (D.-Y.K., J.-M.A., H.K., Y.C., J.L., D.-W.P., S.-J.P.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Won","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 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