{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:53Z","timestamp":1791216473832,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiac troponin (cTn) is key in diagnosing myocardial infarction (MI). After MI, the clinically observed half-life of cTn has been reported to be 7 to 20 hours, but this estimate reflects the combined elimination and simultaneous release of cTn from cardiomyocytes. More precise timing of myocardial injuries necessitates separation of these 2 components. We used a novel method for determination of isolated cTn elimination kinetics in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients with MI were included within 24 hours after revascularization and underwent plasmapheresis to obtain plasma with a high cTn concentration. After at least 3 weeks, patients returned for an autologous plasma retransfusion followed by blood sampling for 8 hours. cTn was measured with 5 different high-sensitivity cTn assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Of 25 included patients, 20 participants (mean age, 64.5 years; SD, 8.2 years; 4 women [20%]) received a retransfusion after a median of 5.8 weeks (interquartile range, 5.0\u20136.9 weeks) after MI. After retransfusion of a median of 620 mL (range, 180\u2013679 mL) autologous plasma, the concentration of cTn in participants\u2019 blood increased 4 to 445 times above the upper reference level of the 5 high-sensitivity cTn assays. The median elimination half-life ranged from 134.1 minutes (95% CI, 117.8\u2013168.0) for the Elecsys high-sensitivity cTnT assay to 239.7 minutes (95% CI, 153.7\u2013295.1) for the Vitros high-sensitivity cTnI assay. The median clearance of cTnI ranged from 40.3 mL\/min (95% CI, 32.0\u201344.9) to 52.7 mL\/min (95% CI, 42.2\u201357.8). The clearance of cTnT was 77.0 mL\/min (95% CI, 45.2\u201395.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This novel method showed that the elimination half-life of cTnI and cTnT was 5 to 16 hours shorter than previously reported. This indicates a considerably longer duration of cardiomyocyte cTn release after MI than previously thought. Improved knowledge of timing of myocardial injury may call for changes in the management of MI and other disorders with myocardial injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.123.066565","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T05:16:09Z","timestamp":1725945369000},"page":"1187-1198","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans"],"prefix":"10.1161","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-0502","authenticated-orcid":true,"given":"Jonas Henrik","family":"Kristensen","sequence":"first","affiliation":[{"name":"Departments of Cardiology (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Emergency Medicine (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Department of Clinical Medicine (J.H.K., R.B.H., N.S., S.A., M.D., N.R.J., J.K., K.D., H.B., K.K.I.), University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-6268","authenticated-orcid":true,"given":"Rasmus Bo","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Emergency Medicine (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Department of Clinical Medicine (J.H.K., R.B.H., N.S., S.A., M.D., N.R.J., J.K., K.D., H.B., K.K.I.), University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-4541","authenticated-orcid":true,"given":"Nina","family":"Strandkj\u00e6r","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Emergency Medicine (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Department of Clinical Medicine (J.H.K., R.B.H., N.S., S.A., M.D., N.R.J., J.K., K.D., H.B., K.K.I.), University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."},{"name":"Emergency Medicine (J.H.K., R.B.H., N.S., N.J., K.K.I.), Copenhagen University Hospital\u2013Herlev and Gentofte, Herlev, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Cardiothoracic Anaesthesiology (M.\u00d8. 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