{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:53:35Z","timestamp":1793134415278,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,11,26]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Sacubitril\/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is an established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared with angiotensin-converting enzyme inhibitors in children. PANORAMA-HF (Prospective Trial to Assess the Angiotensin Receptor Blocker Neprilysin Inhibitor LCZ696 Versus Angiotensin-Converting Enzyme Inhibitor for the Medical Treatment of Pediatric HF) is a randomized, double-blind trial that evaluated the pharmacokinetics and pharmacodynamics (PK\/PD), safety, and efficacy of sacubitril\/valsartan versus enalapril in children 1 month to &lt;18 years of age with HF attributable to systemic left ventricular systolic dysfunction (LVSD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Children with HF attributable to LVSD were randomized to sacubitril\/valsartan versus enalapril to assess the efficacy and safety of sacubitril\/valsartan at 52 weeks of follow-up. The primary end point of the study was to determine whether sacubitril\/valsartan was superior to enalapril for the treatment of pediatric patients with HF attributable to systemic LVSD, assessed using a primary global rank end point consisting of ranking patients from worst to best on the basis of clinical events such as death, listing for urgent heart transplant, mechanical life support requirement, worsening HF, New York Heart Association (NYHA)\/Ross class, Patient Global Impression of Severity (PGIS), and Pediatric Quality of Life Inventory physical functioning domain. The change from baseline to 52 weeks in NT-proBNP (N-terminal pro\u2013B-type natriuretic peptide) was an exploratory end point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 375 children (mean age, 8.1\u00b15.6 years; 52% female) were randomized to sacubitril\/valsartan (N=187) or enalapril (N=188). At week 52, no significant difference was observed between the 2 treatment arms in the global rank end point (Mann-Whitney probability, 0.52 [95% CI, 0.47\u20130.58]; Mann-Whitney odds, 0.91 [95% CI, 0.72\u20131.14];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.42). At week 52, clinically meaningful reductions were observed in both treatment arms in NYHA\/Ross, PGIS, Patient Global Impression of Change, and NT-proBNP, without significant differences between groups. Adverse events were similar between treatment arms (incidence: sacubitril\/valsartan, 88.8%; enalapril, 87.8%), and the safety profile of sacubitril\/valsartan was acceptable in children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In this study, sacubitril\/valsartan did not show superiority over enalapril in the treatment of children with HF attributable to systemic LVSD using the prespecified global rank end point. However, both treatment arms showed clinically meaningful improvements over 52 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02678312.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.123.066605","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T08:48:55Z","timestamp":1727254135000},"page":"1756-1766","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["Sacubitril\/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial"],"prefix":"10.1161","volume":"150","clinical-trial-number":[{"clinical-trial-number":"nct02678312","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-5238","authenticated-orcid":true,"given":"Robert","family":"Shaddy","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital Los Angeles and the Keck School of Medicine of the University of Southern California, Los Angeles (R.S., P.F.K., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9762-7042","authenticated-orcid":true,"given":"Michael","family":"Burch","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children, London, UK (M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-1563","authenticated-orcid":true,"given":"Paul F.","family":"Kantor","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Los Angeles and the Keck School of Medicine of the University of Southern California, Los Angeles (R.S., P.F.K., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-8359","authenticated-orcid":true,"given":"Susan","family":"Solar-Yohay","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, NJ (S.S.-Y., M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Garito","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland (T.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-4921","authenticated-orcid":true,"given":"Sijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Novartis, Shanghai, China (S.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-3623","authenticated-orcid":true,"given":"Michele","family":"Kocun","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, NJ (S.S.-Y., M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-5621","authenticated-orcid":true,"given":"Chad","family":"Mao","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta and Emory University, GA (C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2347-6663","authenticated-orcid":true,"given":"Antoinette","family":"Cilliers","sequence":"additional","affiliation":[{"name":"Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4887-3367","authenticated-orcid":true,"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China (X.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-7337","authenticated-orcid":true,"given":"Charles","family":"Canter","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, St. Louis, MO (C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-0673","authenticated-orcid":true,"given":"Joseph","family":"Rossano","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia, PA (J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Wallis","sequence":"additional","affiliation":[{"name":"Levine Children\u2019s Hospital, Charlotte, NC (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-5808","authenticated-orcid":true,"given":"Jondavid","family":"Menteer","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Los Angeles and the Keck School of Medicine of the University of Southern California, Los Angeles (R.S., P.F.K., J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Daou","sequence":"additional","affiliation":[{"name":"Hotel Dieu de France Hospital, Beirut, Lebanon (L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-1491","authenticated-orcid":true,"given":"Jacek","family":"Kusa","sequence":"additional","affiliation":[{"name":"Regional Specialist Hospital in Wroclaw, Poland (J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-1795","authenticated-orcid":true,"given":"Kursat","family":"Tokel","sequence":"additional","affiliation":[{"name":"Baskent University Medical Faculty, Ankara, Turkey (K.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dilber","sequence":"additional","affiliation":[{"name":"University Hospital Centre, Zagreb, Croatia (D.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6731-2787","authenticated-orcid":true,"given":"Zhuoming","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine, China (Z.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xiao","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Shanghai, China (T.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-7831","authenticated-orcid":true,"given":"Nancy","family":"Halnon","sequence":"additional","affiliation":[{"name":"Mattel Children\u2019s Hospital and David Geffen School of Medicine, UCLA, Los Angeles, CA (N.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-1532","authenticated-orcid":true,"given":"Kevin P.","family":"Daly","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital and Harvard Medical School, MA (K.P.D., T.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-4698","authenticated-orcid":true,"given":"Matthew J.","family":"Bock","sequence":"additional","affiliation":[{"name":"Pediatrics, Division of Cardiology, Loma Linda University Children\u2019s Hospital, CA (M.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3856-7726","authenticated-orcid":true,"given":"Warren","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, Morgan Stanley Children\u2019s Hospital of New York, New York (W.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-7966","authenticated-orcid":true,"given":"Tajinder P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital and Harvard Medical School, MA (K.P.D., T.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Congenital &amp; Pediatric Cardiology, Indraprastha Apollo Hospitals, New Delhi, India (M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Levitas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-7882","authenticated-orcid":true,"given":"Michele","family":"Senni","sequence":"additional","affiliation":[{"name":"University of Milan\u2013Bicocca, A.S.S.T. Papa Giovanni XXIII, Bergamo, Italy (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9793-3912","authenticated-orcid":true,"given":"Giorgia","family":"Grutter","sequence":"additional","affiliation":[{"name":"Bambino Ges\u00f9 Children Hospital, IRCSS, Rome, Italy (G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-280X","authenticated-orcid":true,"given":"Gi Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Seoul National University Children\u2019s Hospital, Korea (G.B.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-5949","authenticated-orcid":true,"given":"Jinyoung","family":"Song","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6125-187X","authenticated-orcid":true,"given":"Hyoung Doo","family":"Lee","sequence":"additional","affiliation":[{"name":"Pusan National University Yangsan Hospital Yangsan-si, Gyeongsangnam-Do, Korea (H.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-3539","authenticated-orcid":true,"given":"Ching Kit","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (C.K.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-4750","authenticated-orcid":true,"given":"Joan","family":"Sanchez-de-Toledo","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de Deu Esplugues de Llobregat, Spain (J.S.-d.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-4812","authenticated-orcid":true,"given":"Yuk","family":"Law","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, WA (Y.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-9099","authenticated-orcid":true,"given":"Suthep","family":"Wanitkun","sequence":"additional","affiliation":[{"name":"Ramathibodi Hospital Mahidol University, Bangkok, Thailand (S.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Cui","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center Guangzhou, Guangdong, China (Y.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-2697","authenticated-orcid":true,"given":"Rui","family":"Anjos","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Lisboa Ocidental EPE Hospital de Santa Cruz Carnaxide, Lisboa, Portugal (R.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-3929","authenticated-orcid":true,"given":"Timur","family":"Mese","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey Dr. Behcet Uz Childrens Hospital-Konak\/Izmir, Turkey (T.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8722-5805","authenticated-orcid":true,"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"M3C-Necker, Congenital and Paediatric Cardiology Department, Hospital Necker-Enfants Malades, University of Paris Cit\u00e9, France (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Ablonczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Agnoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"AlHabdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Amedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ameduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Alberto Annoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Asante-Korang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Audi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Ballweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bosaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Castaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Chag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Chaloupecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Chehab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Daehnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Di Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Dittrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eser","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Donti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritvikrom","family":"Durongpisitkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Favilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Feingold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Garcia-Guereta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gil-Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gomez-Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gorenflo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Gran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Hirono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Sheng","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Inuzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Ishido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Jeewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Won Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kaneva-Nencheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazaros","family":"Kochilas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shine","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Viktorovna Leontyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lytrivi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Malcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marinho da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constancio","family":"Medrano Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Milanesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Deanne Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Odri Komazec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pacileo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Mark Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasubramanian","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Riggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rusconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sabiniewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Salaymeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schweigmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Emmanuelle","family":"Seguela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yurievna Sitnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Spicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Stiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanthan","family":"Sundararaghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuhito","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Beno\u00eet","family":"Thambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conceicao","family":"Trigo Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulal","family":"Ulger Tutar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Vaughn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan","family":"Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Vignati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieh-Neng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jou-Kou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Ziolkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesl","family":"Zuhlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14748"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016520"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-20-358"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.01.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"e_1_3_3_8_2","unstructured":"Novartis. Entresto (sacubitril and valsartan). Prescribing information. Novartis; 2021."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.012"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.12.024"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.07.006"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.122.009816"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.10.1171"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2003)003<0329:tpaapp>2.0.co;2"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.725"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.931"},{"key":"e_1_3_3_18_2","unstructured":"European Medicines Agency. Report on the Expert Group Meeting of Paediatric Heart Failure; London UK; November 29 2010."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.969154"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.926030"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.055"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.069"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2222"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780080407"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2001.25652"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.123.066605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T14:29:37Z","timestamp":1754317777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.123.066605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":24,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11,26]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.123.066605"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.123.066605","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"assertion":[{"value":"2023-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}