{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:47:05Z","timestamp":1792363625087,"version":"4.4.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Renal denervation (RDN) can lower blood pressure (BP) in patients with hypertension in both the presence and absence of medication. This is a sham-controlled trial investigating the safety and efficacy of RDN in China.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This prospective, multicenter, randomized, patient- and outcome-assessor-blinded, sham-controlled trial investigated radiofrequency RDN in patients with hypertension on standardized triple antihypertensive therapy. Eligible patients were randomized 1:1 to undergo RDN using a multi-electrode radiofrequency catheter (Iberis; Shanghai Angiocare Medical Technology, Shanghai, China) or a sham procedure. The primary efficacy outcome was the between-group difference in baseline-adjusted change in mean 24-hour ambulatory systolic BP from randomization to 6 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Of 217 randomized patients (mean age, 45.3\u00b110.2 years; 21% female), 107 were randomized to RDN and 110 were randomized to sham control. At 6 months, there was a greater reduction in 24-hour systolic BP in the RDN (\u221213.0\u00b112.1 mm Hg) compared with the sham control group (\u22123.0\u00b113.0 mm Hg; baseline-adjusted between-group difference, \u22129.4 mm Hg [95% CI, \u221212.8 to \u22125.9];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). Compared with sham, 24-hour diastolic BP was lowered by \u22125.0 mm Hg ([95% CI, \u22127.5 to \u22122.4];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) 6 months after RDN, and office systolic and diastolic BP was lowered by \u22126.4 mm Hg ([95% CI, \u221210.5 to \u22122.3];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.003) and \u22125.1 mm Hg ([95% CI, \u22128.2 to \u22122.0];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.001), respectively. One patient in the RDN group experienced an access site complication (hematoma), which resolved without sequelae. No other major device- or procedure-related safety events occurred through follow-up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In this trial of Chinese patients with uncontrolled hypertension on a standardized triple pharmacotherapy, RDN was safe and reduced ambulatory and office BP at 6 months compared with sham.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02901704.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.124.069215","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T09:00:32Z","timestamp":1725440432000},"page":"1588-1598","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation in Chinese Patients With Uncontrolled Hypertension: The Randomized, Sham-Controlled, Multi-Center Iberis-HTN Trial"],"prefix":"10.1161","volume":"150","clinical-trial-number":[{"clinical-trial-number":"nct02901704","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-8379","authenticated-orcid":true,"given":"Xiongjing","family":"Jiang","sequence":"first","affiliation":[{"name":"Fuwai Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, China (X.J., H.D., R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-549X","authenticated-orcid":true,"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Heart Center, University Hospital Basel, Switzerland (F.M., L.L)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Research &amp; Biometrics Center, National Center for Cardiovascular Diseases, The Chinese Academy of Medical Sciences, China (W.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, China (X.J., H.D., R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-764X","authenticated-orcid":true,"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital, China (J.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhengzhou Central Hospital Affiliated to Zhengzhou University, China (S.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University, China (X.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chengdu Medical Collage, China (P.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hebei University (Z.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-9556","authenticated-orcid":true,"given":"Lucas","family":"Lauder","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Heart Center, University Hospital Basel, Switzerland (F.M., L.L)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-9725","authenticated-orcid":true,"given":"Zhifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinxiang Central Hospital, China (Z.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ji","sequence":"additional","affiliation":[{"name":"Tangshan Workers\u2019 Hospital, China (Z.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-1491","authenticated-orcid":true,"given":"Yifei","family":"Dong","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang University, China (Y.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-0573","authenticated-orcid":true,"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Xuzhou Central Hospital (B. 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