{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:29:00Z","timestamp":1782124140338,"version":"3.54.5"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","funder":[{"name":"Canadian Government | Canadian Institutes of Health Research","award":["PJT-175075"],"award-info":[{"award-number":["PJT-175075"]}]},{"name":"McMaster Surgical Associates","award":["2019-20"],"award-info":[{"award-number":["2019-20"]}]},{"DOI":"10.13039\/100030936","name":"Population Health Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,10,22]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared with intravenous tranexamic acid, which may lower the risk of seizures. We aimed to determine whether topical tranexamic acid reduces the risk of in-hospital seizure without increasing the risk of transfusion among cardiac surgery patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a multicenter, double dummy, blinded, randomized controlled trial of patients recruited by convenience sampling in academic hospitals undergoing cardiac surgery with cardiopulmonary bypass. Between September 17, 2019, and November 28, 2023, a total of 3242 patients from 16 hospitals in 6 countries were randomly assigned (1:1 ratio) to receive either intravenous tranexamic acid (control) through surgery or topical tranexamic acid (treatment) at the end of surgery. The primary outcome was seizure, and the secondary outcome was red blood cell transfusion. After the last planned interim analysis, when 75% of anticipated participants had completed follow up, the data and safety monitoring board recommended to terminate the trial, and upon unblinding, the operations committee stopped the trial for safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 3242 randomized patients (mean age, 66.0 years; 77.7% male), in-hospital seizure occurred in 4 of 1624 patients (0.2%) in the topical group, and 11 of 1628 patients (0.7%) in the intravenous group (absolute risk difference, \u22120.5% [95% CI, \u22120.9 to 0.03];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.07). Red blood cell transfusion occurred in 570 patients (35.1%) in the topical group and in 433 (26.8%) in the intravenous group (absolute risk difference, 8.3% [95% CI, 5.2\u201311.5];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.007). The absolute risk difference in transfusion of \u22654 units of red blood cells in the topical group compared with the intravenous group was 8.2% (95% CI, 3.4\u201312.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Among patients undergoing cardiac surgery, topical administration of tranexamic acid resulted in an 8.3% absolute increase in transfusion without reducing the incidence of seizure, compared with intravenous tranexamic acid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03954314.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.124.069606","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T08:30:49Z","timestamp":1712565049000},"page":"1315-1323","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial"],"prefix":"10.1161","volume":"150","clinical-trial-number":[{"clinical-trial-number":"nct03954314","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-7621","authenticated-orcid":true,"given":"Andr\u00e9","family":"Lamy","sequence":"first","affiliation":[{"name":"Population Health Research Institute, Hamilton, ON, Canada (A.L., E.P.B-C., R.P.W., I.C., J.V., R.K., K.B., S.I.B., M.H.M., J.S., S.Y., P.J.D.)."},{"name":"Surgery (A.L., R.P.W.), McMaster University, Hamilton, ON, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Sirota","sequence":"additional","affiliation":[{"name":"E. Meshalkin National Medical Research Center, Novosibirsk, Russia (D.A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Jacques","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Canada (F.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Poostizadeh","sequence":"additional","affiliation":[{"name":"Kelowna General Hospital, BC, Canada (A.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Noiseux","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), QC, Canada (N.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-9169","authenticated-orcid":true,"given":"Sergey","family":"Efremov","sequence":"additional","affiliation":[{"name":"Saint Petersburg State University Hospital, Russia (S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Demers","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, University of Montr\u00e9al, QC, Canada (P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Akselrod","sequence":"additional","affiliation":[{"name":"Petrovsky National Centre of Surgery, Moscow, Russia (B.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-3830","authenticated-orcid":true,"given":"Chew Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala 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