{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:22:38Z","timestamp":1793874158752,"version":"4.6.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Several sham-controlled trials have investigated the efficacy and safety of catheter-based renal denervation (RDN) with mixed outcomes. We aimed to perform a comprehensive meta-analysis of all randomized, sham-controlled trials investigating RDN with first- and second-generation devices in hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We searched MEDLINE and the Cochrane Library for eligible trials. Outcomes included both efficacy (24-hour and office systolic [SBP] and diastolic blood pressure [DBP]) and safety (all-cause death, vascular complication, renal artery stenosis &gt;70%, hypertensive crisis) of RDN. We performed a study-level, pairwise, random-effects meta-analysis of the summary data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Ten trials comprising 2478 patients with hypertension while being either off or on treatment were included. Compared with sham, RDN reduced 24-hour and office systolic blood pressure by 4.4 mm\u2009Hg (95% CI, 2.7 to 6.1;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.00001) and 6.6 mm\u2009Hg (95% CI, 3.6 to 9.7;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001), respectively. The 24-hour and office diastolic blood pressure paralleled these findings (\u20132.6 mm\u2009Hg [95% CI, \u20133.6 to \u20131.5];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.00001; \u20133.5 mm\u2009Hg [95% CI, \u20135.4 to \u20131.6];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0003). There was no difference in 24-hour and office systolic blood pressure reduction between trials with and without concomitant antihypertensive medication (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for interaction, 0.62 and 0.73, respectively). There was no relevant difference in vascular complications (odds ratio, 1.69 [95% CI, 0.57 to 5.0];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.34), renal artery stenosis (odds ratio, 1.50 [95% CI, 0.06 to 36.97];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.80), hypertensive crisis (odds ratio, 0.65 [95% CI, 0.30 to 1.38];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.26), and all-cause death (odds ratio, 1.76 [95% CI, 0.34 to 9.20];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.50) between RDN and sham groups. Change of renal function based on estimated glomerular filtration rate was comparable between groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for interaction, 0.84). There was significant heterogeneity between trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>RDN safely reduces ambulatory and office systolic blood pressure\/diastolic blood pressure versus a sham procedure in the presence and absence of antihypertensive medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.124.069709","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T05:01:58Z","timestamp":1727845318000},"page":"1599-1611","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis"],"prefix":"10.1161","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-5961","authenticated-orcid":true,"given":"Davor","family":"Vukadinovi\u0107","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Universit\u00e4t des Saarlandes, Homburg, Germany (D.V., L.L., M.B., F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-9556","authenticated-orcid":true,"given":"Lucas","family":"Lauder","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Universit\u00e4t des Saarlandes, Homburg, Germany (D.V., L.L., M.B., F.M.)."},{"name":"Department of Cardiology, University Heart Center, University Hospital Basel, Switzerland (L.L., F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-6655","authenticated-orcid":true,"given":"David E.","family":"Kandzari","sequence":"additional","affiliation":[{"name":"Piedmont Heart Institute, Atlanta, GA (D.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-6245","authenticated-orcid":true,"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY (D.L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-1058","authenticated-orcid":true,"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center\/NewYork-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY (A.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-7156","authenticated-orcid":true,"given":"Elazer R.","family":"Edelman","sequence":"additional","affiliation":[{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge (E.R.E., F.M.)."},{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA (E.R.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-5883","authenticated-orcid":true,"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University Erlangen\/Nuremberg, Germany (R.E.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-8318","authenticated-orcid":true,"given":"Michel","family":"Azizi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Paris, France (M.A.)."},{"name":"Hypertension Department, AP-HP, Hopital, Georges-Pompidou, Paris, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Universit\u00e4t des Saarlandes, Homburg, Germany (D.V., L.L., M.B., F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-549X","authenticated-orcid":true,"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Universit\u00e4t des Saarlandes, Homburg, Germany (D.V., L.L., M.B., F.M.)."},{"name":"Department of Cardiology, University Heart Center, University Hospital Basel, Switzerland (L.L., F.M.)."},{"name":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge (E.R.E., 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