{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:31:54Z","timestamp":1787959914257,"version":"build-2784847793"},"reference-count":159,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:p>Mitral regurgitation and tricuspid regurgitation are the most common valvular heart diseases in patients with heart failure and have independent prognostic value. Transcatheter interventions are now available for the treatment of valvular heart disease, and their efficacy and safety have been tested in randomized controlled trials. However, evidence is still limited and sometimes inconclusive because several aspects of these trials limit their interpretation or consistency. These include heterogeneity in the pathogenesis and clinical characteristics of patients, the dynamic nature of secondary atrioventricular valve disease severity, the role of heart failure medications and devices, dependency on procedural results and operators\u2019 skills, smaller number of patients enrolled and the power to detect differences in trials, and limitations to use patients\u2019 reported outcomes with unblinded study protocols. These specific aspects of trials in patients with atrioventricular valve disease are reviewed in this article with a focus on possible solutions to generate further evidence for the efficacy and safety for transcatheter treatments of atrioventricular valve disease in patients with heart failure.<\/jats:p>","DOI":"10.1161\/circulationaha.124.070411","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T18:00:20Z","timestamp":1746468020000},"page":"1342-1363","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Evidence Generation and Implementation of Transcatheter Interventions for Atrioventricular Valvular Heart Disease in Heart Failure: Current Status and Future Directions"],"prefix":"10.1161","volume":"151","author":[{"given":"Marco","family":"Metra","sequence":"first","affiliation":[{"name":"Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M.M., D.T., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-2857","authenticated-orcid":true,"given":"Daniela","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M.M., D.T., M.A.)."},{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, Stockholm, Sweden (D.T., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":true,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M.M., D.T., M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-8683","authenticated-orcid":true,"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK) of German Heart Center Charit\u00e9, German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charit\u00e9 Universit\u00e4tsmedizin, Germany (S.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-197X","authenticated-orcid":true,"given":"Antoni","family":"Bayes-Genis","sequence":"additional","affiliation":[{"name":"Institut del Cor, Hospital Universitari Germans Trias I Pujol, Barcelona, Spain (A.B.-G.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV; Departamento de Medicina, Universitat Aut\u00f2noma de Barcelona), Barcelona, Spain (A.B.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-0037","authenticated-orcid":true,"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Heart Valve Center, Universit\u00e4tsmedizin Johannes Gutenberg-University, Mainz, Germany (R.S.v.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-2514","authenticated-orcid":true,"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Clinic III, Saarland University Hospital, Homburg\/Saar, Germany (M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-3389","authenticated-orcid":true,"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"University of Rennes, CHU Rennes, Inserm, LTSI\u2013UMR 1099, France (E.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5640-0332","authenticated-orcid":true,"given":"Gerasimos S.","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens, Greece (G.S.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-1709","authenticated-orcid":true,"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"Valve Center IRCCS Ospedale San Raffaele, Cardiac Surgery, University Vita Salute, Milan, Italy (F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-7064","authenticated-orcid":true,"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroclaw Medical University Poland (P.P.)."},{"name":"Institute of Heart Diseases, University Hospital, Wroclaw, Poland (P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-0887","authenticated-orcid":true,"given":"Gianluigi","family":"Savarese","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, Stockholm, Sweden (D.T., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-165X","authenticated-orcid":true,"given":"Fabien","family":"Praz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland (F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-4720","authenticated-orcid":true,"given":"Javed","family":"Butler","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Research Institute, Dallas, TX (J.B.)."},{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson (J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.813"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038946"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.06.014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1830"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00570-z"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2858"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2929"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.11.018"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n1421"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-022-01991-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.11.002"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx402"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae060"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2276"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001582"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.018"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.09.029"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-01086"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027504"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.08.016"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805374"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.07.021"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1491"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab086"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz222"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300213"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3286"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314328"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.012"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.09.050"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.12.015"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.09.005"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.06.031"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.810200"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2362"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2310"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2408739"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.08.062"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.05.009"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30157"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.07.004"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.072648"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.008"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad783"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad653"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae088"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3106"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad585"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.028"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.029"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jead016"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.122.011958"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3075"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex143"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac209"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115961"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.11.022"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.07.035"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.07.030"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2637"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-20-01094"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.05.011"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.05.005"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa138"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-00191"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009685"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.09.050"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1975"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs465"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa129"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.10.015"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1752"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.031"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2401918"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.09.033"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.05.008"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300525"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab255"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.06.009"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2613"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad584"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.01.362"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037077"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeac068"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069144"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.03.009"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2216709"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad195"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2020.100486"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010042"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad667"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2316"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3081"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.04.017"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.08.023"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae082"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.05.006"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.018"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.036"},{"key":"e_1_3_3_109_2","unstructured":"Adams DH. TRILUMINATE Pivotal: outcomes of both randomized and single-arm subjects with transcatheter tricuspid valve edge-to-edge repair for tricuspid regurgitation. 2023. Accessed December 1 2024. https:\/\/tctmd.com\/slide\/triluminate-pivotal-outcomes-both-randomized-and-single-arm-subjects-transcatheter-tricuspid"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.02.049"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.08.026"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.028"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.21189"},{"key":"e_1_3_3_114_2","unstructured":"US Food and Drug Administration. Summary of safety and effectiveness data (SSED): device trade name: Edwards EVOQUE Tricuspid Valve Replacement System. Accessed December 1 2024. https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf23\/P230013B.pdf"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2778"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.10.015"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.049"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.542"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.04.019"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.122.012888"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.07.006"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.05.022"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00016-2"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3195"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.4266"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3274"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.10.008"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.29"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.07.024"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2874"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.06.034"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2467"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1418"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa665"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2853"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.014"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-22-00725"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.07.010"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.08.012"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.08.016"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad678"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.042"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00077"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad335"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2295"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2664"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad356"},{"key":"e_1_3_3_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.01.003"},{"key":"e_1_3_3_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.12.015"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.03.050"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.919395"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1774"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01553-9"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2162"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.039"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.014"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32600-5"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.01.016"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.023"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.06.011"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.124.070411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T18:00:39Z","timestamp":1751911239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.124.070411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":159,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,5,6]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.124.070411"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.124.070411","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"2025-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}