{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:43:00Z","timestamp":1790419380915,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["U01 HL133817"],"award-info":[{"award-number":["U01 HL133817"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["U01 HL132853"],"award-info":[{"award-number":["U01 HL132853"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Government | Canadian Institutes of Health Research","award":["342193"],"award-info":[{"award-number":["342193"]}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-16-RHUS-00010"],"award-info":[{"award-number":["ANR-16-RHUS-00010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2024,12,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The MINT trial (Myocardial Ischemia and Transfusion) raised concern for harm from a restrictive versus liberal transfusion strategy in patients with acute myocardial infarction (MI) and anemia. Type 1 and type 2 MI are distinct pathophysiologic entities that may respond differently to blood transfusion. This analysis sought to determine whether the effects of transfusion varied among patients with a type 1 or a type 2 MI and anemia. The authors hypothesized that the liberal transfusion strategy would be of greater benefit in type 2 than in type 1 MI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>The authors compared rates of death or MI at 30 days in patients with type 1 (n=1460) and type 2 (n=1955) MI and anemia who were randomly allocated to a restrictive (threshold, 7\u20138 g\/dL) or a liberal (threshold, 10 g\/dL) transfusion strategy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The primary outcome of death or MI was observed in 16% of type 1 MI and 15.4% of type 2 MI patients. The rate of death or MI was higher in patients with type 1 MI randomized to a restrictive (18.2%) versus liberal (13.8%) transfusion strategy (relative risk [RR], 1.32 [95% CI, 1.04\u20131.67]) with no difference observed between the restrictive (15.8%) and liberal (15.1%) transfusion strategies in patients with type 2 MI (RR, 1.05 [95% CI, 0.85\u20131.29]). The test for a differential effect of transfusion strategy by MI type was not statistically significant (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              = 0.16).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>The concern for harm with a restrictive transfusion strategy in patients with acute MI and anemia raised in the MINT primary outcome manuscript may be more apparent in patients with type 1 than type 2 MI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02981407.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circulationaha.124.071208","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:00:50Z","timestamp":1724922050000},"page":"1826-1836","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial"],"prefix":"10.1161","volume":"150","clinical-trial-number":[{"clinical-trial-number":"nct02981407","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-9748","authenticated-orcid":true,"given":"Andrew P.","family":"DeFilippis","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (A.P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-0155","authenticated-orcid":true,"given":"J. Dawn","family":"Abbott","sequence":"additional","affiliation":[{"name":"Lifespan Cardiovascular Institute and Department of Medicine, Division of Cardiology, Alpert Medical School of Warren Alpert Medical School. Brown University, Providence, RI (J.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-7422","authenticated-orcid":true,"given":"Brandon M.","family":"Herbert","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Public Health, PA (B.M.H., M.H.B., M.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-9033","authenticated-orcid":true,"given":"Marnie H.","family":"Bertolet","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Public Health, PA (B.M.H., M.H.B., M.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-5317","authenticated-orcid":true,"given":"Bernard R.","family":"Chaitman","sequence":"additional","affiliation":[{"name":"St Louis University School of Medicine, MO (B.R.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-6750","authenticated-orcid":true,"given":"Harvey D.","family":"White","sequence":"additional","affiliation":[{"name":"Green Lane Coordinating Center, Auckland, New Zealand (H.D.W., C.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-7837","authenticated-orcid":true,"given":"Andrew M.","family":"Goldsweig","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baystate Medical Center, Springfield, MA (A.M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-9244","authenticated-orcid":true,"given":"Tamar S.","family":"Polonsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Medicine, IL (T.S.P.M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-7671","authenticated-orcid":true,"given":"Rajesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, University of Toledo, OH (R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9463-0165","authenticated-orcid":true,"given":"Caroline","family":"Alsweiler","sequence":"additional","affiliation":[{"name":"Green Lane Coordinating Center, Auckland, New Zealand (H.D.W., C.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-2808","authenticated-orcid":true,"given":"Johanne","family":"Silvain","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, ACTION Study Group, INSERM UMRS1166, Institut de Cardiologie H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re (AP-HP), Paris, France (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-4470","authenticated-orcid":true,"given":"Pedro G.M.","family":"de Barros e Silva","sequence":"additional","affiliation":[{"name":"Brazilian Clinical Research Institute, Sao Paulo (P.G.M.dBeS.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-4673","authenticated-orcid":true,"given":"Graham S.","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Perth Hospital and Medical School, University of Western Australia, Perth (G.S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Daneault","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Sherbrooke, QC, Canada (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meechai","family":"Tessalee","sequence":"additional","affiliation":[{"name":"Department 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M.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-2833","authenticated-orcid":true,"given":"Jeffrey L.","family":"Carson","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (J.L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-2440","authenticated-orcid":true,"given":"Shaun G.","family":"Goodman","sequence":"additional","affiliation":[{"name":"St Michael\u2019s Hospital, Unity Health Toronto and Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto (S.G.G.)."},{"name":"Canadian VIGOUR (Virtual Coordinating Centre for Global Collaborative Cardiovascular Research) Centre, University of Alberta, Edmonton (S.G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MINT 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