{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:58:27Z","timestamp":1792205907873,"version":"4.4.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Few middle-aged and older adults engage in regular leisure-time exercise. Incidental physical activity (IPA) encompasses activities of daily living outside the leisure-time domain. No dose-response study is available to guide IPA-focused interventions and guidelines. We examined the associations of device-assessed IPA intensities (vigorous [VIPA], moderate [MIPA], light [LIPA]) with major adverse cardiovascular events (MACE) and mortality, and we estimated the \u201chealth equivalence\u201d of LIPA and MIPA against 1 minute of VIPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A total of 24\u2009139 nonexercisers from the 2013 to 2015 UK Biobank accelerometry substudy (56.2% women) with a mean\u00b1SD age of 61.9\u00b17.6 years were analyzed using a prospective cohort design. IPA energy expenditure and daily durations of VIPA, MIPA, and LIPA were calculated with a validated machine learning-based intensity classifier. MACE included incident stroke, myocardial infarction, and heart failure; CVD death; CVD mortality; and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Analyses included 22\u2009107 (MACE), 22\u2009174 (CVD mortality), and 24\u2009139 (all-cause mortality) participants, corresponding to 908\/223\/1071 events over 7.9 years of follow-up. IPA volume exhibited an L-shaped association with a nadir at \u224835 to 38 kJ\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      \u00b7d\n                      <jats:sup>\u22121<\/jats:sup>\n                      , corresponding to hazard ratios of 0.49 (95% CI, 0.39\u20130.61) for MACE, 0.33 (95% CI, 0.22\u20130.52) for CVD mortality, and 0.31 (95% CI, 0.25\u20130.38) for all-cause mortality. Any amounts of VIPA or MIPA were associated with lower risk, with a plateau of \u224814 minutes per day (VIPA) and 34 to 50 minutes per day (MIPA). The median VIPA (4.6 min\/d) and MIPA (23.8 min\/d) durations were associated with CVD mortality hazard ratio of 0.62 (95% CI, 0.46\u20130.83) and 0.50 (95% CI, 0.31\u20130.80), respectively. LIPA showed a subtle inverse gradient which was statistically significant only for CVD mortality at levels &gt;130 minutes per day. One minute of VIPA was equivalent to 2.8 (MACE) to 3.4 (CVD mortality) minutes of MIPA and 34.7 (CVD mortality) to 48.5 (MACE) minutes of LIPA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Any daily IPA amount of vigorous or moderate intensity was associated with lower CVD risk in a dose-response manner. LIPA had weak associations with all outcomes. One minute of vigorous or \u22483.0 to 3.5 minutes of moderate IPA was associated with a similar degree of lower CVD risk. Our findings highlight the potential cardiovascular health value of incidental physical activity, especially for people who struggle to do structured exercise.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.124.072253","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T14:00:21Z","timestamp":1744639221000},"page":"1063-1075","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Dose Response of Incidental Physical Activity Against Cardiovascular Events and Mortality"],"prefix":"10.1161","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7323-3225","authenticated-orcid":true,"given":"Emmanuel","family":"Stamatakis","sequence":"first","affiliation":[{"name":"Mackenzie Wearables Research Hub, Charles Perkins Centre (E.S., R.K.B., N.A.K., A.S., M.N.A.)"},{"name":"School of Health Sciences, Faculty of Medicine and Health, University of Sydney, NSW, 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