{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:40Z","timestamp":1787018080896,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","funder":[{"name":"Edwards Lifesciences","award":["GARG"],"award-info":[{"award-number":["GARG"]}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Comprehensive knowledge of the clinical presentation, contemporary management, and outcomes on \u201call-comer\u201d patients referred for mitral valve surgery (MVS) are critical to evaluate current practice and adherence to guidelines, understand selection biases, and inform key stakeholders on quality improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>MITRACURE is a large international retrospective registry of consecutive adult patients who underwent isolated or combined MVS for mitral regurgitation (MR) in France or Canada in 2019 with in-depth clinical and echocardiographic characterization. Patients operated on for isolated mitral stenosis or who had a prior mitral valve intervention were excluded. Data were obtained from detailed chart abstraction and were site reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>In 2019, 3522 patients underwent MVS (48% combined) across 40 centers (88\u00b146 MVSs\/center, median 80, interquartile [51\u2013131]). Mean age was 65\u00b112 years, and 35% were women. The most common MR etiology was myxomatous (61%), followed by functional (9%), infective endocarditis (9%), and rheumatic disease (7%). MR quantification was performed in only 43%. Advanced clinical presentation was common: 43% were in New York Heart Association class III\/IV, 30% exhibited congestive heart failure, 47% were on diuretics, 22% had atrial fibrillation\/flutter, 35% presented with reduced ejection fraction, and 22% had pulmonary hypertension (\u226550 mm Hg). Most patients were symptomatic or presented with class I\/IIa indication for intervention, and an early intervention was performed only in 3% of patients. The repair rate was 62% overall and 80% in myxomatous disease. In-hospital mortality was 4.5% overall but 2.3% in patients with myxomatous MR (1.8% isolated, 3.1% combined).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>MITRACURE provides a contemporary, multicenter, \u201creal-world\u201d picture of the clinical presentation, management, and in-hospital outcomes of MVS for MR in two Western countries. Patients were often referred late in the disease process, with few patients undergoing early intervention. The higher mortality and lower repair rates reported may be more reflective of an unselected MR patient population but have room for improvement. Our results underline the need to develop strategies to improve management and outcomes of patients with MR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.124.073674","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:40:09Z","timestamp":1756636809000},"page":"927-938","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Presentation and Outcomes After Surgery for Mitral Regurgitation: Real-World Insights From the MITRACURE International Registry"],"prefix":"10.1161","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-5670","authenticated-orcid":true,"given":"David","family":"Messika-Zeitoun","sequence":"first","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada (D.M.-Z., A.Y.N.F., R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9872-399X","authenticated-orcid":true,"given":"Michael W.A.","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, Western University, London, ON, Canada (M.W.A.C., L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-6504","authenticated-orcid":true,"given":"Denis","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Department of Surgery, Montreal Heart Institute, Montreal, QC, Canada (D.B., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0110-9054","authenticated-orcid":true,"given":"Thierry","family":"Le Tourneau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, CHU de Nantes, CNRS, INSERM, L\u2019institut du Thorax, 44000 Nantes, France (T.L.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5864","authenticated-orcid":true,"given":"Julien","family":"Ternacle","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, CHU de Bordeaux, 33600 Pessac, France (J.T.)."},{"name":"INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, 33604 Pessac, France (J.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Demers","sequence":"additional","affiliation":[{"name":"Department of Surgery, Montreal Heart Institute, Montreal, QC, Canada (D.B., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linrui","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of Surgery, Western University, London, ON, Canada (M.W.A.C., 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