{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:36:10Z","timestamp":1790706970580,"version":"4.1.0"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2026,2,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>We report IMPROVE-DiCE (Improve Diabetic Cardiac Energetics), a 2-part open-label, phase 2a trial evaluating the safety and effectiveness of ninerafaxstat, a novel therapeutic designed to enhance cardiac energetics. Between May and September 2021, part 1 enrolled patients with type 2 diabetes and obesity without heart failure with preserved ejection fraction (HFpEF). Between January 2023 and June 2024, part 2 enrolled patients with type 2 diabetes, obesity, and HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Forty-two participants received 200 mg ninerafaxstat twice daily (part 1, n=21, 43% women, 72\u00b10.5 years of age, 4\u20138 weeks; part 2, n=21, 29% women, 71\u00b16 years of age, 12 weeks). Myocardial energetics (phosphocreatine-to-ATP ratio [PCr\/ATP], primary outcome) and function (rest and dobutamine stress) were assessed before and after treatment using magnetic resonance imaging,\n                      <jats:sup>31<\/jats:sup>\n                      P- and\n                      <jats:sup>1<\/jats:sup>\n                      H magnetic resonance spectroscopy. In part 1, hyperpolarized [1-\n                      <jats:sup>13<\/jats:sup>\n                      C]pyruvate magnetic resonance spectroscopy to assess in vivo pyruvate dehydrogenase flux (n=9) and plasma metabolomics and proteomics were also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In part 1, in patients with diabetes and obesity but without HFpEF, the heart was characterized by impaired pyruvate dehydrogenase flux, reduced PCr\/ATP, triglyceride deposition, and diastolic impairment. Treatment with ninerafaxstat was associated with improved PCr\/ATP (+0.39\u00b10.49 [95% CI, 0.16\u20130.62]; Cohen\u2019s\n                      <jats:italic toggle=\"yes\">d<\/jats:italic>\n                      , 0.79;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002) and lower myocardial triglyceride (by 34%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.03). In part 2, in patients with diabetes, obesity, and symptomatic HFpEF, the heart was characterized by reduced PCr\/ATP, diastolic impairment, and failure of systolic augmentation to exercise. Consistently, treatment with ninerafaxstat was associated with improvement in PCr\/ATP (+0.15\u00b10.25 [95% CI, 0.03\u20130.26]; Cohen\u2019s\n                      <jats:italic toggle=\"yes\">d<\/jats:italic>\n                      , 0.60;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02), improved systolic augmentation to exercise (+1.4 L\/min,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04), improved exercise capacity (6-minute walk distance +16 m,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02), and improved New York Heart Association class symptom burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>These mechanistic phase 2a study results show that ninerafaxstat is safely tolerated and improves myocardial energetics in participants with obesity and diabetes without or with clinically manifest HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04826159.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.125.074041","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:00:48Z","timestamp":1766052048000},"page":"550-563","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["IMPROVE-DiCE, a 2-Part, Open-Label, Phase 2a Trial Evaluating the Safety and Effectiveness of Ninerafaxstat in Patients With Cardiometabolic Syndromes"],"prefix":"10.1161","volume":"153","clinical-trial-number":[{"clinical-trial-number":"nct04826159","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Moritz J.","family":"Hundertmark","sequence":"first","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."},{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (M.J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Birkhoelzer","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Portwood","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5568-1145","authenticated-orcid":true,"given":"Adrienne G.","family":"Siu","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."},{"name":"Department of Physiology, Anatomy and Genetics, Medical Sciences Division, Oxford, United Kingdom (A.G.S., J.G., D.J.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-5942","authenticated-orcid":true,"given":"Violet","family":"Matthews","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (V.M., R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-6711","authenticated-orcid":true,"given":"Andrew J.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Grist","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."},{"name":"Department of Physiology, Anatomy and Genetics, Medical Sciences Division, Oxford, United Kingdom (A.G.S., J.G., D.J.T.)."},{"name":"Department of Radiology, Oxford University Hospitals NHS Foundations Trust, Oxford, United Kingdom (J.G.)."},{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom (J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"M\u00f3zes","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-0963","authenticated-orcid":true,"given":"John A.","family":"Henry","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Patel","sequence":"additional","affiliation":[{"name":"Imbria Pharmaceuticals, Boston, MA (J.P., P.C., A.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chamberlin","sequence":"additional","affiliation":[{"name":"Imbria Pharmaceuticals, Boston, MA (J.P., P.C., A.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-2528","authenticated-orcid":true,"given":"Rizwan","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom (V.M., R.S.)."},{"name":"Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (R.S., A.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Yavari","sequence":"additional","affiliation":[{"name":"Imbria Pharmaceuticals, Boston, MA (J.P., P.C., A.Y.)."},{"name":"Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom (R.S., A.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-0178","authenticated-orcid":true,"given":"Hakim-Moulay","family":"Dehbi","sequence":"additional","affiliation":[{"name":"Comprehensive Clinical Trials Unit, University College London, London, United Kingdom (H.-M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."},{"name":"CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-0359","authenticated-orcid":true,"given":"Xu","family":"Shi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."},{"name":"CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuning","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."},{"name":"CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-4841","authenticated-orcid":true,"given":"Jeremy M.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."},{"name":"CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-7687","authenticated-orcid":true,"given":"Robert E.","family":"Gerszten","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."},{"name":"CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA (P.R., X.S., S.Z., J.M.R., R.E.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-8024","authenticated-orcid":true,"given":"Michael P.","family":"Frenneaux","sequence":"additional","affiliation":[{"name":"Imperial College London (M.P.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-3642","authenticated-orcid":true,"given":"Ladislav","family":"Valkovi\u010d","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."},{"name":"Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia (L.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-1299","authenticated-orcid":true,"given":"Jack J.J.J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark (J.J.J.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-5645","authenticated-orcid":true,"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian J.","family":"Tyler","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."},{"name":"Department of Physiology, Anatomy and Genetics, Medical Sciences Division, Oxford, United Kingdom (A.G.S., J.G., D.J.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-7769","authenticated-orcid":true,"given":"Oliver J.","family":"Rider","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (M.J.H., S.M.B., C.P., A.G.S., A.J.L., J.G., F.M., J.A.H., L.V., S.N., D.J.T., O.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00465-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1170"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(72)90595-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-021-01407-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000691"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.03.020"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318241"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx018"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa217"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0339-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.14.6452"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072789.89096.10"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042770"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316260"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv442"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.597"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr212"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.054858"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0511-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(21)01898-2"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.03.387"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz641"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz108"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00610-6"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1350"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185356"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23011"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.09.002"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.007275"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13406"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0627"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.069518"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.7.2190"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5206"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2016.1126248"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306842"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.645614"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.062"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.068"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0263-2"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.086"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-012-0174-6"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.077"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9080248"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0270"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi816"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.09.009"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065134"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069479"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062021"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1143658"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14816"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0921"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.04.064"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14418"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.10.018"},{"key":"e_1_3_3_61_2","first-page":"996","article-title":"Effect of nicotinic acid on exogenous myocardial glucose utilization.","volume":"36","author":"Stone CK","year":"1995","unstructured":"Stone CK, Holden JE, Stanley W, Perlman SB. Effect of nicotinic acid on exogenous myocardial glucose utilization. J Nucl Med. 1995;36:996\u20131002.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd7064"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2012.01029.x"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1350"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.125.074041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:50:19Z","timestamp":1773935419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.125.074041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":63,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,2,24]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.125.074041"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.125.074041","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"2025-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}