{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:00:09Z","timestamp":1784383209990,"version":"3.55.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UKRI | Medical Research Council","award":["MR\/S021108\/1"],"award-info":[{"award-number":["MR\/S021108\/1"]}]},{"name":"UKRI | Medical Research Council","award":["MR\/V001620\/1"],"award-info":[{"award-number":["MR\/V001620\/1"]}]},{"name":"UKRI | Medical Research Council","award":["MR\/W000520\/1"],"award-info":[{"award-number":["MR\/W000520\/1"]}]},{"name":"NIHR | NIHR Imperial Biomedical Research Centre","award":["302493"],"award-info":[{"award-number":["302493"]}]},{"name":"British Heart Foundation","award":["FS\/ICRF\/22\/26051"],"award-info":[{"award-number":["FS\/ICRF\/22\/26051"]}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2025,12,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Little correlation exists between the burden of ischemia and severity of angina in patients with stable coronary artery disease. This placebo-controlled, n-of-1 study investigated the relationship between ischemia, the collateral circulation, and symptoms in stable coronary artery disease. Additionally, it explored the association between progressive collateral recruitment and ischemic preconditioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Fifty-one participants with severe single-vessel coronary artery disease and angina were recruited. Antianginal medications were stopped, and daily angina symptoms were documented using a dedicated smartphone application (ORBITA [Objective Randomized Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina] app) for 14 days before undergoing invasive pressure wire studies and coronary flow reserve assessment. Each participant then underwent four 60-s episodes of low-pressure balloon occlusion across their coronary stenosis. Each episode was paired with an audiovisually identical placebo inflation in a randomized order. After each episode, participants scored pain intensity on a 10-point scale, and a placebo-controlled pain intensity score was calculated. Collateral flow index was calculated from simultaneous measures of aortic, right atrial, and distal coronary wedge pressure during balloon occlusion. Higher\n                      <jats:italic toggle=\"yes\">Pr<\/jats:italic>\n                      values from Bayesian models indicate a greater likelihood of association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean (\u00b1SD) age of participants was 63\u00b19 years, and 78% were men. The median (interquartile range) fractional flow reserve was 0.68 (0.57\u20130.79), the median instantaneous wave-free ratio was 0.80 (0.48\u20130.89), and the median coronary flow reserve was 1.42 (1.08\u20131.85). Daily angina frequency showed little correlation with severity of ischemia, as assessed by fractional flow reserve (Somers\u2019 D 0.124,\n                      <jats:italic toggle=\"yes\">Pr<\/jats:italic>\n                      =0.057) or instantaneous wave-free ratio (Somers\u2019 D 0.056,\n                      <jats:italic toggle=\"yes\">Pr<\/jats:italic>\n                      =0.150). However, there was strong evidence of an association between lower fractional flow reserve and instantaneous wave-free ratio values and greater collateral flow (Somers\u2019 D 0.302,\n                      <jats:italic toggle=\"yes\">Pr<\/jats:italic>\n                      =0.998 and Somers\u2019 D 0.316,\n                      <jats:italic toggle=\"yes\">Pr<\/jats:italic>\n                      =0.999, respectively). There was also strong evidence of an association between more collateralization (higher collateral flow index) and lower pain intensity scores (Somers\u2019 D 0.341,\n                      <jats:italic toggle=\"yes\">Pr<\/jats:italic>\n                      =0.999). Finally, pain intensity scores and collateral flow index remained stable between sequential balloon occlusion episodes within individual patients, indicating little evidence of ischemic preconditioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Coronary collateralization is associated with ischemic burden and may reduce the intensity of ischemic chest pain. This may explain the nonlinear relationship between stenosis, ischemia, and angina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04280575.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.125.074687","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:40:13Z","timestamp":1761601213000},"page":"1541-1551","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study"],"prefix":"10.1161","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-1113","authenticated-orcid":true,"given":"Christopher A.","family":"Rajkumar","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0330-5542","authenticated-orcid":true,"given":"Michael J.","family":"Foley","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiyyaz","family":"Ahmed-Jushuf","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-7309","authenticated-orcid":true,"given":"Shayna","family":"Chotai","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-6525","authenticated-orcid":true,"given":"Florentina A.","family":"Simader","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1170-6492","authenticated-orcid":true,"given":"Muhammad","family":"Mohsin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Salih","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashiananthan","family":"Ganesananthan","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Bual","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Petraco","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhjinder S.","family":"Nijjer","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Sen","sequence":"additional","affiliation":[{"name":"One Heart Clinic, London, UK (S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joban","family":"Sehmi","sequence":"additional","affiliation":[{"name":"West Hertfordshire Hospitals NHS Trust, Watford, UK (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-2750","authenticated-orcid":true,"given":"Neil","family":"Ruparelia","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Royal Berkshire NHS Foundation Trust, Reading, UK (N.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-6813","authenticated-orcid":true,"given":"Jason N.","family":"Dungu","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."},{"name":"Anglia Ruskin School of Medicine and MTRC, Chelmsford, UK (J.N.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alamgir","family":"Kabir","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kare","family":"Tang","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Gamma","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2693-5114","authenticated-orcid":true,"given":"John R.","family":"Davies","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-4817","authenticated-orcid":true,"given":"Tushar","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK (T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-0335","authenticated-orcid":true,"given":"Graham D.","family":"Cole","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-6331","authenticated-orcid":true,"given":"James P.","family":"Howard","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-7994","authenticated-orcid":true,"given":"Thomas R.","family":"Keeble","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."},{"name":"Anglia Ruskin School of Medicine and MTRC, Chelmsford, UK (J.N.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-841X","authenticated-orcid":true,"given":"Gerald J.","family":"Clesham","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Mid and South Essex NHS Foundation Trust, Basildon, UK (J.N.D., A.K., K.T., R.G., J.R.D., T.R.K., G.J.C.)."},{"name":"Anglia Ruskin School of Medicine and MTRC, Chelmsford, UK (J.N.D., T.R.K., G.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5245-4547","authenticated-orcid":true,"given":"Peter D.","family":"O\u2019Kane","sequence":"additional","affiliation":[{"name":"University Hospitals Dorset NHS Foundation Trust, Bournemouth, UK (P.D.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-5493","authenticated-orcid":true,"suffix":"Jr","given":"Frank E.","family":"Harrell","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, TN (F.E.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-0814","authenticated-orcid":true,"given":"Darrel P.","family":"Francis","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-0867","authenticated-orcid":true,"given":"Matthew J.","family":"Shun-Shin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-5532","authenticated-orcid":true,"given":"Rasha K.","family":"Al-Lamee","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., M.M., A.S., S.G., R.P., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, UK (C.A.R., M.J.F., F.A.-J., S.C., F.A.S., S.G., N.B., R.P., S.S.N., N.R., G.D.C., J.P.H., D.P.F., M.J.S.-S., R.K.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.1139"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32714-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810320407"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.04.016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038"},{"key":"e_1_3_3_8_2","unstructured":"Lower R. Tractatus de corde. Apud Conradum Wishoff; 1740."},{"key":"e_1_3_3_9_2","unstructured":"Heberden W. Medical transactions published by the College of Physicians in London. London Barker S Doodley J 1772."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016442"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.930651"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(01)02186-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.11.3026"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.804187"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.04.001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00111-G"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00384-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042918"},{"key":"e_1_3_3_19_2","unstructured":"Harrell F. (2024). rmsb: Bayesian Regression Modeling Strategies. R package version 1.1-1 Accessed March 1 2025.<https:\/\/CRAN.R-project.org\/package=rmsb> 10.32614\/cran.package.rmsb"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90091-x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960220911"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.4.6.797"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90502-0"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(96)00499-8"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01861.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143624.72027.11"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.19.1945"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv626"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01675-8"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.74.5.1124"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00674-3"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(03)00055-x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(85)80380-6"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.125.074687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T19:00:33Z","timestamp":1764615633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.125.074687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":32,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,12,2]]}},"alternative-id":["10.1161\/CIRCULATIONAHA.125.074687"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.125.074687","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"2025-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}