{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:14:20Z","timestamp":1793726060685,"version":"4.6.1"},"reference-count":87,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiac sarcoidosis (CS) is an enigmatic disorder characterized by unexplained patchy, sterile granulomas intermixed with preserved myocardium and fibrotic regions without granuloma. CS causes arrhythmias, sudden cardiac death, and heart failure. The mechanisms producing this remarkable histopathology and disease progression remain unexplained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Using comprehensive single-cell and spatial transcriptomic analyses, we characterized the cellular composition and gene expression in preserved, granulomatous, and fibrotic regions of human CS hearts. From unexpectedly identified clonally expanded cardiac B cells with rearranged immunoglobulin sequences, we reconstructed antibodies and screened libraries comprising the human peptidome or microbial and allergen peptides to define reactive epitopes in CS hearts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Cellular composition and gene expression differed substantially in CS tissues with preserved, granulomatous, or fibrotic histopathology. Cardiomyocytes upregulated arrhythmogenic and inflammasome transcripts associated with pyroptosis. Cardiomyocytes and fibroblasts activated chemoattractant cytokines that sustained myeloid and lymphoid infiltration. Granulomas contained abundant macrophages expressing modulators of cell\u2013cell fusion, along with Th17-skewed T cells that upregulated B-cell\u2013activating factor, thereby promoting antibody production. Fibrotic regions, without active granulomas, exhibited tertiary lymphoid structures, with clonal expansion of mature B and plasma cells. Reconstructed antibodies derived from expanded B-cell clones were inert to microbial and allergen peptides, but reacted to PPL (periplakin), a desmosome protein, and other peptides expressed on cardiac cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Progressive inflammatory signals in CS are mediated by chemoattractant genes in cardiomyocytes and fibroblasts within preserved myocardium, cell\u2013cell fusion modulators in activated macrophages within granulomatous regions, and tertiary lymphoid structures in fibrotic regions that produce patient-specific autoimmune antibodies. Identification of PPL as a CS autoantigen may account for shared clinical manifestations in CS and arrhythmic desmosomal cardiomyopathies. CS autoantigens may underlie enigmatic histopathologic findings, perpetuate disease, and contribute to adverse outcomes. Uncovering an intracardiac humoral autoimmune axis in CS provides specific therapeutic opportunities to limit granuloma formation and B-cell activation, which may reduce arrhythmogenicity and progressive dysfunction. Parallel analytic strategies have potential to define autoantigens in other enigmatic cardiac immune disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.126.079304","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:00:47Z","timestamp":1779958847000},"page":"2011-2028","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Integrative Molecular Analyses of Inflammatory and Autoimmune Signals in Cardiac Sarcoidosis"],"prefix":"10.1161","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0343-0562","authenticated-orcid":true,"given":"Meraj","family":"Neyazi","sequence":"first","affiliation":[{"name":"Department of Genetics (M.N., G.V., K.J.B., Y.C., J.M.G., O.G.L., A. Verma, A.J.W., B.A.M., D.M.D., S.R.D., D.R., H.W., S.J.E., J.G.S., C.E.S.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA."},{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.N.)."},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site North, Hamburg, Germany (M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-2296","authenticated-orcid":true,"given":"Gabriela","family":"Venturini","sequence":"additional","affiliation":[{"name":"Department of Genetics (M.N., G.V., K.J.B., Y.C., J.M.G., O.G.L., A. Verma, A.J.W., B.A.M., D.M.D., S.R.D., D.R., H.W., S.J.E., J.G.S., C.E.S.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2184-4654","authenticated-orcid":true,"given":"Kemar J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Genetics (M.N., G.V., K.J.B., Y.C., J.M.G., O.G.L., A. Verma, A.J.W., B.A.M., D.M.D., S.R.D., D.R., H.W., S.J.E., J.G.S., C.E.S.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA."},{"name":"Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (K.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-855X","authenticated-orcid":true,"given":"Youjung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Genetics (M.N., G.V., K.J.B., Y.C., J.M.G., O.G.L., A. Verma, A.J.W., B.A.M., D.M.D., S.R.D., D.R., H.W., S.J.E., J.G.S., C.E.S.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA."},{"name":"Biomedical Research Institute (Y.C.), Seoul National University Hospital, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-4690","authenticated-orcid":true,"given":"Joshua M.","family":"Gorham","sequence":"additional","affiliation":[{"name":"Department of Genetics (M.N., G.V., K.J.B., Y.C., J.M.G., O.G.L., A. Verma, A.J.W., B.A.M., D.M.D., S.R.D., D.R., H.W., S.J.E., J.G.S., C.E.S.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7476-9117","authenticated-orcid":true,"given":"Olivia G.","family":"Layton","sequence":"additional","affiliation":[{"name":"Department of Genetics (M.N., G.V., K.J.B., Y.C., J.M.G., O.G.L., A. 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