{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:55:31Z","timestamp":1790675731130,"version":"4.1.0"},"reference-count":70,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Epigenetic mechanisms underlying susceptibility to abdominal aortic aneurysm (AAA) remain poorly understood. Identifying causal DNA methylation markers for AAA can elucidate the regulatory processes that drive aneurysm formation and accelerate translational applications. We leveraged the Veterans Affairs (VA) Million Veteran Program to identify methylation biomarkers and delineate underlying pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We first conducted an epigenome-wide association study of incident AAA (1324 cases and 42 065 noncases), performed stratified analyses by population group and smoking status, and conducted Mendelian randomization to facilitate causal inference of the CpG\u2013AAA association. Chromatin state, island context, and transcription factor binding were implicated through functional annotation of identified CpGs. To identify genes impacted by change in methylation state, we aligned associations with transcriptional data obtained in blood, aorta, and liver. We performed expression quantitative trait methylation to capture CpG\u2013gene-expression links across the genome. Network Mendelian randomization was used to test cardiometabolic and inflammatory mediation. Finally, we developed a methylation risk score for AAA using penalized regression and evaluated its performance against a clinical model in the Million Veteran Program and 2 external studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Epigenome-wide association study identified 1253 CpGs associated with incident AAA, and Mendelian randomization supported a putative causal role for 143 of these associations. Functional annotation pointed to predominantly distal, enhancer-centered regulation and enrichment of inflammatory transcription factor programs (eg, activator protein-1 and nuclear factor \u03baB). This distal architecture was consistent with expression quantitative trait methylation results, which showed a larger number of trans associations. Among 143 CpGs associated with AAA in Mendelian randomization analyses, we identified 213 CpG\u2013gene expression pairs with strong colocalization support, including\n                      <jats:italic toggle=\"yes\">AGER, C2<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">DDR1<\/jats:italic>\n                      . Multi-trait colocalization further prioritized 8 CpG\u2013gene expression\u2013AAA links with evidence of a shared genetic signal. Network Mendelian randomization identified 135 putative mediation pathways linking CpGs to AAA, including 58 via cardiometabolic traits and 77 via inflammation-related traits. Blood lipid traits mediated &gt;40% of the associations between AAA risk and CpGs near\n                      <jats:italic toggle=\"yes\">LDLR<\/jats:italic>\n                      (cg19305903) and\n                      <jats:italic toggle=\"yes\">TRIB1<\/jats:italic>\n                      (cg14128479). Among inflammation-related mediators, circulating DAG1, NEXN, MMP9, IL1RN, and MMP13 were prioritized as potential intermediates. Additionally, a CpG selection process was used to develop a methylation risk score for AAA, which strongly associated with disease in both the discovery cohort and 2 external validation cohorts, even after adjustment for a full suite of clinical covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This study identified putative causal DNA methylation markers for AAA, and multi-omics analyses implicate activator protein-1\u2013linked inflammatory transcriptional programs, blood lipids, and multiple inflammation-related proteins as key pathways underlying methylation-associated AAA risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.126.079863","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:01:06Z","timestamp":1790672466000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenome-Wide Association Study of Abdominal Aortic Aneurysm Identifies Central Role for Inflammatory Pathways"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-5627","authenticated-orcid":true,"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."},{"name":"Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.Y.)."},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (S.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (M.G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9599-6351","authenticated-orcid":true,"given":"Gabrielle","family":"Shakt","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-9932","authenticated-orcid":true,"given":"Michael G.","family":"Levin","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-9653","authenticated-orcid":true,"given":"Katherine","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-2222","authenticated-orcid":true,"given":"Renae","family":"Judy","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia","family":"Dinatale","sequence":"additional","affiliation":[{"name":"VA Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Heath Care System, Salt Lake City, UT (T.D., A.V., J.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Voorhees","sequence":"additional","affiliation":[{"name":"VA Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Heath Care System, Salt Lake City, UT (T.D., A.V., J.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0108-2127","authenticated-orcid":true,"given":"Julie A.","family":"Lynch","sequence":"additional","affiliation":[{"name":"VA Informatics and Computing Infrastructure (VINCI), VA Salt Lake City Heath Care System, Salt Lake City, UT (T.D., A.V., J.A.L.)."},{"name":"Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT (J.A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-3762","authenticated-orcid":true,"given":"Saiju","family":"Pyarajan","sequence":"additional","affiliation":[{"name":"Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA (S.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1843-8724","authenticated-orcid":true,"given":"Daniel","family":"Levy","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Framingham, MA (D.L., R.J.)."},{"name":"National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (D.L., R.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-9054","authenticated-orcid":true,"given":"Roby","family":"Joehanes","sequence":"additional","affiliation":[{"name":"Framingham Heart Study, Framingham, MA (D.L., R.J.)."},{"name":"National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (D.L., R.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6811-9364","authenticated-orcid":true,"given":"Kyong-Mi","family":"Chang","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."},{"name":"Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (K.-M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-148X","authenticated-orcid":true,"given":"Jennifer A.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-1110","authenticated-orcid":true,"given":"Joshua C.","family":"Bis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-2190","authenticated-orcid":true,"given":"Bruce M.","family":"Psaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F.","family":"Voight","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."},{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (B.F.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-9318","authenticated-orcid":true,"given":"Philip S.","family":"Tsao","sequence":"additional","affiliation":[{"name":"VA Palo Alto Healthcare System, Palo Alto, CA (P.S.T.)."},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA (P.S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6950-4210","authenticated-orcid":true,"given":"Gregory T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Otago, Dunedin, New Zealand (G.T.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-1632","authenticated-orcid":true,"given":"Scott M.","family":"Damrauer","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (S.Y., G.S., M.G.L., K.H., R.J., K.-M.C., B.F.V., S.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitra","family":"Muralidhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Deen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitra","family":"Muralidhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Oslin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Voora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica V.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Brophy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Churby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob T.","family":"Kean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E.","family":"Selva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahpoor (Alex)","family":"Shayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey B.","family":"Whitbourne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.11.019"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.03.435"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2021.02.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9825"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)11522-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0030-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0114-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-024-00760-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176334"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100727"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj1182"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2023.2185742"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky691"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318327"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-86"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1131-9"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntaf165"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58357-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00092-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21998"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01510-y"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21998"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/35093131"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv612"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw024"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0213-x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20885-8"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00913-z"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39936-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu176"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjmed-2022-000335"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2005.127"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(91)90005-w"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7213760"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109575"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10017"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-004-0050-5"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X11422110"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.10.016"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.321087"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.227652"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b41a18"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-025-02027-2"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aan3286"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-025-01382-z"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00520-1"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2025.4491"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.118.002413"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17048"},{"key":"e_1_3_3_59_2","volume-title":"Low-dose colchicine inhibit abdominal aortic aneurysm growth trial","author":"Luo J","year":"2022","unstructured":"Luo J. Low-dose colchicine inhibit abdominal aortic aneurysm growth trial. 2022;clinicaltrials.govhttps:\/\/clinicaltrials.gov\/study\/NCT05361772"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae093"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0460-9"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky691"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1131-9"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047544"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14248"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv612"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20885-8"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39936-3"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu176"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCULATIONAHA.126.079863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:01:07Z","timestamp":1790672467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.126.079863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":70,"alternative-id":["10.1161\/CIRCULATIONAHA.126.079863"],"URL":"https:\/\/doi.org\/10.1161\/circulationaha.126.079863","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"CIRCULATIONAHA.126.079863"}}