{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:12:34Z","timestamp":1788858754856,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Fibrosis assessed through late gadolinium enhancement (LGE) in cardiac magnetic resonance imaging and genetics have emerged as risk markers of ventricular arrhythmias in nonischemic dilated cardiomyopathy. Conduction corridors detected within LGE (ie, LGE corridors) have been associated with ventricular arrhythmias in ischemic cardiomyopathy. This study sought to evaluate major ventricular arrhythmic events (MVAs) according to the presence of LGE corridors combined with high-risk genotypes (HRGs) in nonischemic dilated cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We studied consecutive patients with nonischemic dilated cardiomyopathy from 22 European centers who had undergone genetic testing and cardiac magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 925 patients (mean age, 54.5 years [interquartile range, 43.7\u201363.9 years]; 64% men; mean left ventricular ejection fraction, 37.6% [26.9%\u201344.8%]; LGE in 24.3%), LGE corridors were present in 160 patients (17.3%), and HRG in 119 (12.9%). After a median follow-up of 5.4 years (interquartile range, 3.3\u20137.7), 95 patients (10.3%) experienced an MVA. In multivariable competing-risk analysis adjusted for left ventricular ejection fraction and extent of LGE, the number of LGE corridors and HRGs were independently associated with MVA (subdistribution hazard ratio, 1.25 [95% CI, 1.11\u20131.42];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001; and subdistribution hazard ratio, 2.28 [95% CI, 1.32\u20133.96];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.003, respectively). An optimal cutoff of \u22654 LGE corridors predicted MVA. A stepwise risk stratification algorithm to predict MVA integrating LGE, the presence of \u22654 LGE corridors, and HRG outperformed left ventricular ejection fraction \u226435%\u2013based classification proposed in guidelines (5-year time-dependent area under the curve, 0.72 [95% CI, 0.65\u20130.78] versus 0.57 [95% CI, 0.51\u20130.64];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), showing a progressive increase in arrhythmic risk across categories (Gray test\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and allowing clinically meaningful arrhythmic risk classification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>LGE corridors and HRGs provide additive value for arrhythmic risk stratification in patients with nonischemic dilated cardiomyopathy. These findings support MVA multiparametric prediction over the traditional left ventricular ejection fraction \u226435% threshold.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.126.080608","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:00:19Z","timestamp":1788858019000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Arrhythmic Risk Stratification According to LGE Corridors and Genetics in Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-1707","authenticated-orcid":true,"given":"Noem\u00ed","family":"Ramos-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain (N.R.-L., N.M.-A., P.G.-P., J.G.M.)."},{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain (N.R.-L., J.P.O., A.G.-\u00c1., P.G.-P.)."},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, the Netherlands (N.R.-L., N.M.-A., E.P., G.C., C.R.B., J.F.R.-P., A.S.A., P.G.-P., J.G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-5287","authenticated-orcid":true,"given":"Nerea","family":"Mora-Ayestar\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain (N.R.-L., N.M.-A., P.G.-P., J.G.M.)."},{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, the Netherlands (N.R.-L., N.M.-A., E.P., G.C., C.R.B., J.F.R.-P., A.S.A., P.G.-P., J.G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-0313","authenticated-orcid":true,"given":"Juan Pablo","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain (N.R.-L., J.P.O., A.G.-\u00c1., P.G.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Claver","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitari de Bellvitge (E.C., J.S., A.d.M.), l\u2019Hospitalet de Llobregat, Spain."},{"name":"Bioheart Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL; E.C., J.S., A.d.M.), l\u2019Hospitalet de Llobregat, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"G\u00f3mez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain (C.G.G., E.R.G., M.\u00c1.E.C.)."},{"name":"Facultad de Medicina, Universidad Complutense de Madrid, Spain (C.G.G., E.R.G., M.\u00c1.E.C.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain (C.G.G., E.R.G., M.\u00c1.E.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-5129","authenticated-orcid":true,"given":"Edwin","family":"Poel","sequence":"additional","affiliation":[{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, the Netherlands (N.R.-L., N.M.-A., E.P., G.C., C.R.B., J.F.R.-P., A.S.A., P.G.-P., J.G.M.)."},{"name":"Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure &amp; Arrhythmias, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands (E.P., C.R.B., A.S.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-8568","authenticated-orcid":true,"given":"M\u00f3nica","family":"Garc\u00eda Monsalvo","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Department of Cardiology, CSUR Cardiopat\u00edas Familiares, Hospital Universitario de Salamanca, Gerencia Regional de Salud de Castilla y Le\u00f3n, Salamanca, Spain (M.G.M., M.G.D.)."},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca, Spain (M.G.M., M.G.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-320X","authenticated-orcid":true,"given":"Guillem","family":"Casas","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, the Netherlands (N.R.-L., N.M.-A., E.P., G.C., C.R.B., J.F.R.-P., A.S.A., P.G.-P., J.G.M.)."},{"name":"Department of Cardiology, Vall d\u2019Hebron Hospital Universitari (G.C., J.F.R.-P.), Vall d\u2019Hebron Barcelona Hospital Campus, Spain."},{"name":"Cardiovascular Diseases, Vall d\u2032Hebron Institut de Recerca (VHIR; G.C., J.F.R.-P.), Vall d\u2019Hebron Barcelona Hospital Campus, Spain."},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Spain (G.C., J.F.R.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mu\u00f1oz-Esparza","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Unidad de Cardiopatias Familiares (CSUR\/ERN), Hospital Universitario Virgen de la Arrixaca, Murcia, Spain (C.M.-E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-0301","authenticated-orcid":true,"given":"Mar\u00eda Teresa","family":"Basurte-Elorz","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Navarra, IdiSNA, Pamplona, Spain (M.T.B.-E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Larra\u00f1aga-Moreira","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Inherited Cardiac Disease Unit, Hospital Universitario de A Coru\u00f1a (HUAC), Servizo Galego de Sa\u00fade (SERGAS), A Coru\u00f1a, Spain (J.M.L.-M.)."},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Universidade da Coru\u00f1a (UDC), A Coru\u00f1a, Spain (J.M.L.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Garc\u00eda-Pinilla","sequence":"additional","affiliation":[{"name":"Inherited Cardiac Diseases and Heart Failure Unit, Medicine and Dermatology Department, Hospital Universitario Virgen de la Victoria, M\u00e1laga, Spain (J.M.G.-P.)."},{"name":"Institute for Biomedical Research M\u00e1laga, IBIMA-Plataforma BIONAND, M\u00e1laga, Spain (J.M.G.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-0206","authenticated-orcid":true,"given":"Mar\u00eda Victoria","family":"Mogoll\u00f3n Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda, Complejo Hospitalario Universitario de C\u00e1ceres, Spain (M.V.M.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-1446","authenticated-orcid":true,"given":"Gonzalo","family":"Cabez\u00f3n Villalba","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Department of Cardiology, Instituto de Ciencias del Coraz\u00f3n, Hospital Cl\u00ednico Universitario Valladolid, Spain (G.C.V.)."},{"name":"Institute for Biomedical Research Valladolid (IBioVALL), Valladolid, Spain (G.C.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Espejo Bares","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Department of Cardiology, Hospital Universitario 12 de Octubre, Madrid, Spain (V.E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7835-3722","authenticated-orcid":true,"given":"Mar\u00eda","family":"Ruiz-Cueto","sequence":"additional","affiliation":[{"name":"Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.R.-C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-8174","authenticated-orcid":true,"given":"Bernardo","family":"L\u00f3pez-Abel","sequence":"additional","affiliation":[{"name":"Xen\u00e9tica Cardiovascular, Instituto de Investigaci\u00f3n Sanitaria de Santiago, Unidad de Cardiopat\u00edas Familiares, Complexo Hospitalario Universitario de Santiago de Compostela, Spain (B.L.-A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-2424","authenticated-orcid":true,"given":"Ana","family":"Garc\u00eda-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain (N.R.-L., J.P.O., A.G.-\u00c1., P.G.-P.)."},{"name":"Cardiology Department, Hospital Cl\u00ednic Barcelona, IDIBAPS, Universitat de Barcelona, Spain (A.G.-\u00c1.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7362-1922","authenticated-orcid":true,"given":"Vicente","family":"Climent-Pay\u00e1","sequence":"additional","affiliation":[{"name":"Heart Failure and Inherited Cardiac Diseases Unit, Cardiology Department, Dr Balmis General University Hospital, Alicante, Spain (V.C.-P.)."},{"name":"Institute for Health and Biomedical Research of Alicante (ISABIAL), Alicante, Spain (V.C.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-5907","authenticated-orcid":true,"given":"Coloma","family":"Tir\u00f3n","sequence":"additional","affiliation":[{"name":"Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitari Dr Josep Trueta, Girona, Spain (C.T.)."},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona Dr Josep Trueta (IDIBGI), Girona, Spain (C.T.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares, Madrid, Spain (C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2997-2391","authenticated-orcid":true,"given":"Eva","family":"Cabrera-Borrego","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Virgen de las Nieves, Granada, Spain (E.C.-B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4861-0831","authenticated-orcid":true,"given":"Mar\u00eda Luisa","family":"Pe\u00f1a-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Inherited Cardiac Diseases Unit, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain (M.L.P.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-325X","authenticated-orcid":true,"given":"Tomas","family":"Ripoll-Vera","sequence":"additional","affiliation":[{"name":"Inherited Cardiac Diseases Unit, Cardiology Department, Hospital Universitario Son Llatzer and Institut d\u2019Investigaci\u00f2 Sanit\u00e0ria Illes Balears, Palma, Spain (T.R.-V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-4210","authenticated-orcid":true,"given":"Esther","family":"Zorio","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Grupo de Investigaci\u00f3n en Cardiopat\u00edas Familiares, Muerte S\u00fabita y Mecanismos de Enfermedad (CAFAMUSME), Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe), Valencia, Spain (E.Z.)."},{"name":"Department of Medicine, Faculty of Medicine and Dentistry, Universitat de Val\u00e8ncia, Spain (E.Z.)."},{"name":"Inherited Cardiac Diseases Unit, Cardiology Department, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain (E.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sana\u00fa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitari de Bellvitge (E.C., J.S., A.d.M.), l\u2019Hospitalet de Llobregat, Spain."},{"name":"Bioheart Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL; E.C., J.S., A.d.M.), l\u2019Hospitalet de Llobregat, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-9034","authenticated-orcid":true,"given":"Elena","family":"Rodr\u00edguez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (N.R.-L., N.M.-A., C.G.G., M.G.M., G.C., C.M.-E., J.M.G.-P., G.C.V., V.E.B., A.G.-\u00c1., E.Z., E.R.G., M.G.D., J.F.R.-P., A.d.M., M.\u00c1.E.C., P.G.-P., J.G.M.)."},{"name":"Department of Cardiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain (C.G.G., E.R.G., M.\u00c1.E.C.)."},{"name":"Facultad de Medicina, Universidad Complutense de Madrid, Spain (C.G.G., E.R.G., M.\u00c1.E.C.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Spain 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