{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:57:14Z","timestamp":1793087834903,"version":"4.5.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2026,10,27]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Heart failure with reduced ejection fraction causes high mortality and recurrent hospitalizations in India. We evaluated the effectiveness of the collaborative care model in improving days alive and out of the hospital and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a parallel-group, cluster-randomized controlled trial involving 1507 adults with heart failure with reduced ejection fraction across 22 centers in India (CTRI\/2021\/11\/037797). Centers were randomized 1:1 to the intervention or usual care. Participants were followed up for 2 years. The intervention included risk stratification, lifestyle and pharmacological optimization, and a nurse-coordinated, mobile health\u2013supported disease management program with self-care education, active follow-up, and continuous outpatient monitoring throughout the study period. The primary outcome was days alive and out of the hospital, and all-cause mortality was assessed as a secondary outcome. Days alive and out of the hospital was analyzed with a one-inflated \u03b2 model. All-cause mortality was analyzed with Cox proportional hazards models adjusted for the clustered study design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 1507 participants (752 usual care; 755 intervention), the mean age was 61.9 years, and 77.6% were men. All participants except one completed 24 months of follow-up. Most participants (70%) had low educational attainment; 57.3% lived in rural areas; and ischemic heart disease was the predominant cause (77.4%). Baseline characteristics were comparable between the intervention and usual care groups. In the one-inflated \u03b2 model, the probability of surviving up to 730 days without hospitalization was 34.7% (95% CI, 31.2%\u201338.1%) in the usual care group and 46.5% (95% CI, 42.6%\u201349.9%) in the intervention group. Participants in the intervention group had 78% higher odds of achieving a percent days alive and out of the hospital of exactly 1 (730\/730 days) compared with those in the usual care group (odds ratio, 1.78 [95% CI, 1.42\u20132.23]). There were 201 deaths (26.73%) in the usual care group compared with 163 deaths (21.59%) in the intervention group (risk ratio, 0.80 [95% CI, 0.67\u20130.97]). In the multivariable Cox proportional hazards model, the intervention group had a 22% lower mortality risk than the usual care group (hazard ratio, 0.78 [95% CI, 0.63\u20130.95];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>A nurse-coordinated, mobile health\u2013supported collaborative care model for heart failure with reduced ejection fraction in India increased the number of days alive and out of hospital, raised the absolute probability of remaining out of hospital by 11.8 percentage points, and reduced all-cause mortality by 22%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.ctri.nic.in\">www.ctri.nic.in<\/jats:ext-link>\n                      ; Unique identifier: CTRI\/2021\/11\/037797.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circulationaha.126.082490","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T07:37:30Z","timestamp":1788075450000},"page":"1675-1685","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT (India)"],"prefix":"10.1161","volume":"154","clinical-trial-number":[{"clinical-trial-number":"ctri\/2021\/11\/037797","registry":"10.18810\/clinical-trial-registry-india"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4172-4307","authenticated-orcid":true,"given":"Panniyammakal","family":"Jeemon","sequence":"first","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India (P.J., S.G., N.A., S.I., T.A., M.A., A.J., S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Ganapathi","sequence":"additional","affiliation":[{"name":"Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India (P.J., S.G., N.A., S.I., T.A., M.A., A.J., 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