{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:48:35Z","timestamp":1792302515524,"version":"4.4.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,7,24]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Patients with primary pulmonary hypertension (PPH) have a pulmonary vasculopathy that leads to exercise intolerance due to dyspnea and fatigue. To better understand the basis of the exercise limitation in patients with PPH, cardiopulmonary exercise testing (CPET) with gas exchange measurements, New York Heart Association (NYHA) symptom class, and resting pulmonary hemodynamics were studied.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            We retrospectively evaluated 53 PPH patients who had right heart catheterization and cycle ergometer CPET studies to maximum tolerance as part of their clinical workups. No adverse events occurred during CPET. Reductions in peak O\n            <jats:sub>2<\/jats:sub>\n            uptake (V\u0307\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            ), anaerobic threshold, peak O\n            <jats:sub>2<\/jats:sub>\n            pulse, rate of increase in V\u0307\n            <jats:sc>o<\/jats:sc>\n            <jats:sub>2<\/jats:sub>\n            , and ventilatory efficiency were consistently found. NYHA class correlated well with the above parameters of aerobic function and ventilatory efficiency but less well with resting pulmonary hemodynamics.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class.\n          <\/jats:p>","DOI":"10.1161\/hc2901.093198","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":508,"title":["Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension"],"prefix":"10.1161","volume":"104","author":[{"given":"Xing-Guo","family":"Sun","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Hansen","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Oudiz","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlman","family":"Wasserman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360207"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.20.2388"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.4.914"},{"key":"e_1_3_1_6_2","unstructured":"Rich S. Executive summary from the World Symposium on primary pulmonary hypertension 1998. World Health Organization website. Available at: www.who.int\/ncd\/cvd\/pph.html."},{"key":"e_1_3_1_7_2","unstructured":"Wasserman K Hansen JE Sue DY et al. Principles of the Exercise Testing and Interpretation. 3rd ed. Baltimore Md: Lippincott Williams &Wilkins; 1999."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90202-A"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.6.2535"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.24.2803"},{"key":"e_1_3_1_12_2","unstructured":"Portney LG Watkins MP. Foundations of Clinical Research: Applications to Practice. 2nd ed. Upper Saddle River NJ: Prentice-Hall Inc; 2000."},{"key":"e_1_3_1_13_2","unstructured":"Glantz SA Slinker BK. Primer of Applied Regression and Analysis of Variance. San Francisco Calif: McGraw-Hill Inc; 1990."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1967.22.1.71"},{"key":"e_1_3_1_15_2","first-page":"824","volume":"119","year":"2000","unstructured":"Ting H, Sun XG, Chuang ML, et al. A noninvasive assessment of pulmonary perfusion abnormality in patients with primary pulmonary hypertension. Chest. 2000; 119: 824\u2013832.","journal-title":"Chest"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.3.631"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.3.908"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.6.1213"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.4.457"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90513-9"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00464-5"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70102-9"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.102.13.1591"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hc2901.093198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:39:09Z","timestamp":1715650749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hc2901.093198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,24]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,7,24]]}},"alternative-id":["10.1161\/hc2901.093198"],"URL":"https:\/\/doi.org\/10.1161\/hc2901.093198","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,24]]},"assertion":[{"value":"2001-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}