{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:06:42Z","timestamp":1791176802768,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,7,24]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Coronary artery angioplasty triggers healing that causes constrictive remodeling. Because collagen accumulation correlates with constrictive remodeling and aldosterone has been implicated in collagen accumulation, we examined how aldosterone and the mineralocorticoid receptor antagonists spironolactone and eplerenone affect remodeling and collagen in porcine coronary and iliac arteries after angioplasty.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Twenty-four pigs were allocated into 4 treatment groups: oral eplerenone (100 mg\/d), oral spironolactone (200 mg\/d), subcutaneous aldosterone (400 \u03bcg\/d), or no treatment. Twenty-eight days after angioplasty of the coronary arteries, eplerenone increased total vessel area by 30% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) and luminal area by nearly 60% (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) compared with the no-treatment group, without affecting neointima size. These effects were accompanied by a 65% reduction in neointimal and medial collagen density (both\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). Spironolactone was less effective, and aldosterone tended to exert opposite effects on coronary artery structure after angioplasty. These effects were not observed in angioplastied iliac arteries.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Eplerenone attenuates constrictive remodeling after coronary artery angioplasty by mechanisms involving reduction in collagen accumulation, which thus appears to be an important contributor to constrictive remodeling of angioplastied coronary arteries.\n          <\/jats:p>","DOI":"10.1161\/hc3001.091458","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"467-472","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["Eplerenone Suppresses Constrictive Remodeling and Collagen Accumulation After Angioplasty in Porcine Coronary Arteries"],"prefix":"10.1161","volume":"104","author":[{"given":"Michael R.","family":"Ward","sequence":"first","affiliation":[{"name":"From the Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kanellakis","sequence":"additional","affiliation":[{"name":"From the Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Ramsey","sequence":"additional","affiliation":[{"name":"From the Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Funder","sequence":"additional","affiliation":[{"name":"From the Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Bobik","sequence":"additional","affiliation":[{"name":"From the Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.1.35"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.2.475"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.9.1716"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.10.1109"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0040"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.17.6.1152"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00983.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.10.7711"},{"key":"e_1_3_1_10_2","first-page":"III-656.","volume":"82","year":"1990","unstructured":"Schwartz RS, Murphy JG, Edwards WD, et al. Restenosis occurs with internal elastic lamina laceration and is proportional to severity of vessel injury in a porcine coronary artery model. Circulation. 1990; 82 (suppl III): III-656.","journal-title":"Circulation"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.5.1631"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.8.2722"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117269"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.36.4.495"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90092-F"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.2.8339427"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.4.7923611"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.12.2178"},{"key":"e_1_3_1_19_2","first-page":"515","volume":"25","year":"1995","unstructured":"Currier JW, Faxon DP. Restenosis after percutaneous transluminal coronary angioplasty: have we been aiming at the wrong target? J Am Coll Cardiol. 1995; 25: 515\u2013520.","journal-title":"J Am Coll Cardiol"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.73.2.8101140"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)88542-7"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00407-4"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00277.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1025"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0258"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64751-7"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000025728"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708073370601"},{"key":"e_1_3_1_29_2","first-page":"321","volume":"40","year":"1991","unstructured":"Kossor DC, Kominami S, Takemori S, et al. Role of the steroid 17-alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450. Mol Pharmacol. 1991; 40: 321\u2013325.","journal-title":"Mol Pharmacol"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hc3001.091458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:39:24Z","timestamp":1715650764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hc3001.091458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,24]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,7,24]]}},"alternative-id":["10.1161\/hc3001.091458"],"URL":"https:\/\/doi.org\/10.1161\/hc3001.091458","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,24]]},"assertion":[{"value":"2001-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}