{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:18:13Z","timestamp":1791289093111,"version":"4.3.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,8,14]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Proinflammatory cytokines play a role in acute coronary events. However, the potential role of antiinflammatory cytokines in the modulation of the atherosclerotic process remains unknown. Interleukin (IL)-10, which is expressed in human atherosclerotic plaques, has potent deactivating properties in macrophages and T cells. The aim of this study was to assess whether serum concentrations of IL-10 differed between patients with unstable and stable angina pectoris.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            A total of 95 patients with angina pectoris and angiographically documented coronary artery disease were studied. Of these, 50 patients had chronic stable angina (with stable symptoms over 3 months), and 45 patients had Braunwald class IIIB unstable angina with ST-segment changes. Serum IL-10 and IL-6 concentrations were measured on admission using commercially available immunoassays. Serum IL-10 concentrations were lower in unstable angina patients compared with those who had chronic stable angina (28.4 versus 14.0 pg\/mL; 95% CI, 9.8 to 19.0;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001), even after adjustment for variables that were significantly different on univariate analysis. IL-6 concentrations were higher in the unstable angina group (20.9 versus 11.4 pg\/mL; 95% CI, 1.0 to 12.6;\n            <jats:italic>P<\/jats:italic>\n            =0.04).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Patients with unstable angina had significantly lower serum IL-10 concentrations than did patients with chronic stable angina. This important finding is in keeping with previous data from animal model studies that suggest that IL-10 has a protective role in atherosclerosis.\n          <\/jats:p>","DOI":"10.1161\/hc3201.094973","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"746-749","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":184,"title":["Serum Levels of the Antiinflammatory Cytokine Interleukin-10 Are Decreased in Patients With Unstable Angina"],"prefix":"10.1161","volume":"104","author":[{"given":"David A.","family":"Smith","sequence":"first","affiliation":[{"name":"From the Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St George\u2019s Hospital Medical School, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra D.","family":"Irving","sequence":"additional","affiliation":[{"name":"From the Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St George\u2019s Hospital Medical School, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Sheldon","sequence":"additional","affiliation":[{"name":"From the Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St George\u2019s Hospital Medical School, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Della","family":"Cole","sequence":"additional","affiliation":[{"name":"From the Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St George\u2019s Hospital Medical School, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Kaski","sequence":"additional","affiliation":[{"name":"From the Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St George\u2019s Hospital Medical School, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.8.2013"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.11.2844"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.775"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.77.5.863"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.18.8154"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117619"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.790"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89400-3"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90096-5"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.16.2079"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(99)00093-5"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899509002465"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118650"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.19.3.611"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.85.8.e17"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.19.12.2847"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.2.2752565"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(05)80173-5"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00640-3"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.5.874"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.16.9558"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119786"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118286"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00808.x"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31965-8"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2174"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00348.x"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1997.17.145"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70306-9"},{"key":"e_1_3_1_32_2","first-page":"1127","volume":"112","year":"1996","unstructured":"Sugita T, Watarida S, Katsuyama K, et al. 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