{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:14:01Z","timestamp":1784027641723,"version":"3.55.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,8,14]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Hemostasis affects ischemic cardiovascular disease through its role in formation of occluding arterial thrombi. Several studies suggest that hemostasis also might play a role in atherogenesis. We investigated whether individuals with an inherited bleeding tendency are protected against development of atherosclerosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            A total of 76 individuals with an inherited bleeding tendency (hemophilia and von Willebrand disease) and 142 healthy controls were included in the present study. Early atherosclerotic vessel-wall changes were quantified by measurement of intima-media thickness in the carotid and femoral arteries by B-mode ultrasonography. To validate intima-media thickness measurements, measurements also were performed in 77 individuals with clinically proven atherosclerosis and in 34 healthy, age-matched controls. A large difference in intima-media thickness was found between individuals with proven atherosclerosis and healthy controls, in particular for the femoral artery (difference for carotid artery, 0.16 mm; femoral artery, 0.53 mm). Comparison between patients with a bleeding tendency and healthy controls showed only minimally reduced intima-media in femoral artery in individuals with a bleeding tendency (adjusted difference, \u22120.078 mm; 95% CI, \u22120.17 to 0.018 mm). Subgroup analysis revealed that in subjects with moderate to severe hemophilia, vessel walls were thinnest (adjusted difference, \u22120.10 mm; 95% CI, \u22120.27 to 0.061 mm).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Hypocoagulability caused by hemophilia or von Willebrand disease has at most a limited effect on atherogenesis.\n          <\/jats:p>","DOI":"10.1161\/hc3501.094232","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"762-767","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Decreased Coagulability Has No Clinically Relevant Effect on Atherogenesis"],"prefix":"10.1161","volume":"104","author":[{"given":"A.","family":"S\u030cra\u0301mek","sequence":"first","affiliation":[{"name":"From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.C.","family":"Reiber","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.B.J.","family":"Gerrits","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.R.","family":"Rosendaal","sequence":"additional","affiliation":[{"name":"From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408233110804"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90111-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.12.9.1525121"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.17.11.3321"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.7.736"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615188"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07793.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-11-199512010-00002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.5.1747"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.11.1037"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405033101801"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.3.657"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647286"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.1.67"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.51.5.6814782"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200012000-00001"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.6.1399"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01797677"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648848"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1991.tb00336.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116078"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.14.7.8018662"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.14.12.7981175"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.3.386"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.5.351"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/atv91.13.12.8241104"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199412000-00005"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.15.9.1269"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400050094018"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01123.x"},{"key":"e_1_3_2_31_2","first-page":"1018","volume":"112","year":"1988","unstructured":"Glagov S, Zarins C, Giddens DP, et al. Hemodynamics and atherosclerosis: insights and perspectives gained from studies of human arteries. Arch Pathol Lab Med. 1988; 112: 1018\u20131031.","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/107602969900500405"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.4.366"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.15.1467"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.8532481.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.1995.tb00061.x"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hc3501.094232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:45:10Z","timestamp":1715651110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hc3501.094232"}},"subtitle":["Observations in Individuals With a Hereditary Bleeding Tendency"],"short-title":[],"issued":{"date-parts":[[2001,8,14]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,8,14]]}},"alternative-id":["10.1161\/hc3501.094232"],"URL":"https:\/\/doi.org\/10.1161\/hc3501.094232","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,14]]},"assertion":[{"value":"2001-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}