{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:57:10Z","timestamp":1770062230436,"version":"3.49.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,9,11]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Recognizing that mechanical circulatory support with a left ventricular assist device (LVAD) induces changes in myocardial structure and contractile function, we examined whether there are changes in ventricular conduction and\/or repolarization among failing human hearts after LVAD implantation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            We examined 12-lead electrocardiograms before surgery, immediately after LVAD placement, and at a delayed (&gt;1 week) postoperative time point in 23 patients who were receiving LVAD support for refractory heart failure. The immediate effects of hemodynamic unloading via LVAD placement included a decrease in QRS duration from 117\u00b16 to 103\u00b16 ms (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01), an increase in absolute QT duration from 359\u00b16 to 378\u00b18 ms (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05), and an increase in the heart rate-corrected QT interval (QTc) from 379\u00b110 to 504\u00b111 ms (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01). None of these immediate changes were observed among 22 patients undergoing routine coronary artery bypass grafting. With sustained cardiac unloading via LVAD support, there was a marked decrease in the QTc from 504\u00b111 to 445\u00b19 ms (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Studies in isolated cardiac myocytes, obtained at the time of transplantation, confirmed that delayed decreases in heart rate-adjusted QTc were the result of decreases in action potential duration after LVAD support.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Acute electrocardiogram responses to LVAD placement demonstrate the dependence of QRS and QT duration on load in the failing human heart. Delayed decreases in QTc and action potential duration reflect reversal of electrophysiologic remodeling in the failing heart. Shortening of the action potential duration likely contributes to the improved cellular contractile performance observed after sustained LVAD support.\n          <\/jats:p>","DOI":"10.1161\/hc3601.095718","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"1241-1247","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Electrophysiological Alterations After Mechanical Circulatory Support in Patients With Advanced Cardiac Failure"],"prefix":"10.1161","volume":"104","author":[{"given":"John D.","family":"Harding","sequence":"first","affiliation":[{"name":"From the Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Valentino","family":"Piacentino","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Gaughan","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Houser","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth B.","family":"Margulies","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Group, Temple University School of Medicine, Philadelphia, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00017-6"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(99)00077-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-000-0067-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2000.7190"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.23.2316"},{"key":"e_1_3_2_6_2","first-page":"353","volume":"7","year":"1920","unstructured":"Bazett HC. An analysis of the time relationship of the electrocardiogram. Heart. 1920; 7: 353\u2013370.","journal-title":"Heart"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90035-B"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1920.tb18266.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00555-2"},{"key":"e_1_3_2_10_2","first-page":"765","volume":"16","year":"1997","unstructured":"Altemose GT, Gritsus V, Jeevanandam V, et al. Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy. 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