{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:41Z","timestamp":1787018081138,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,9,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Background<\/jats:italic>\n                        <\/jats:bold>\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    The Prospective Randomized Enalapril Study Evaluating Regression of Ventricular Enlargement (PRESERVE) study was designed to test whether enalapril achieves greater left ventricular (LV) mass reduction than does a nifedipine gastrointestinal treatment system by a prognostically meaningful degree on a population basis (10 g\/m\n                    <jats:sup>2<\/jats:sup>\n                    ).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Methods and Results<\/jats:italic>\n                        <\/jats:bold>\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    An ethnically diverse population of 303 men and women with essential hypertension and increased LV mass at screening echocardiography were enrolled at clinical centers on 4 continents and studied by echocardiography at baseline and after 6- and 12-month randomized therapy. Clinical examination and blinded echocardiogram readings 48 weeks after study entry in an intention-to-treat analysis of 113 enalapril-treated and 122 nifedipine-treated patients revealed similar reductions in systolic\/diastolic pressure (\u221222\/12 versus \u221221\/13 mm Hg) and LV mass index (\u221215 versus \u221217g\/m\n                    <jats:sup>2<\/jats:sup>\n                    , both\n                    <jats:italic>P<\/jats:italic>\n                    &gt;0.20). No significant between-treatment difference was detected in population subsets defined by monotherapy treatment, sex, age, race, or severity of baseline hypertrophy. Similarly, there was no between-treatment difference in change in velocities of early diastolic or atrial phase transmitral blood flow. More enalapril-treated than nifedipine-treated patients required supplemental treatment with hydrochlorothiazide (59% versus 34%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) but not atenolol (27% versus 22%, NS).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>\n                        <jats:bold>\n                          <jats:italic>Conclusions<\/jats:italic>\n                        <\/jats:bold>\n                      <\/jats:italic>\n                    <\/jats:bold>\n                    Once-daily antihypertensive treatment with enalapril or long-acting nifedipine, plus adjunctive hydrochlorothiazide and atenolol when needed to control blood pressure, both had moderately beneficial and statistically indistinguishable effects on regression of LV hypertrophy.\n                  <\/jats:p>","DOI":"10.1161\/hc3601.095927","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T14:31:09Z","timestamp":1190989869000},"page":"1248-1254","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":149,"title":["Effects of Once-Daily Angiotensin-Converting Enzyme Inhibition and Calcium Channel Blockade-Based Antihypertensive Treatment Regimens on Left Ventricular Hypertrophy and Diastolic Filling in Hypertension"],"prefix":"10.1161","volume":"104","author":[{"given":"Richard B.","family":"Devereux","sequence":"first","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Palmieri","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Sharpe","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"De Quattro","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Bella","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"de Simone","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Findlay","family":"Walker","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjo\u0308rn","family":"Dahlo\u0308f","sequence":"additional","affiliation":[{"name":"From Cornell Medical Center, New York, NY (R.B.D., V.P., J.N.B., G.d.S., R.T.H.); Auckland Hospital, Aukland, New Zealand (N.S.); University of Southern California, Los Angeles (V.D.Q.); Merck &amp; Co, Whitehouse Station, NJ (J.F.W.); and University of Go\u0308teborg, Go\u0308teborg, Sweden (B.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.88.4.8403291"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-5-345"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199312000-00016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520010045030"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-10-831"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90717-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.4.7923663"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199510000-00003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.97.1.48"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.2.95"},{"key":"e_1_3_2_12_2","first-page":"85","volume":"6","year":"1992","unstructured":"Cruickshank J, Lewis J, Moore V, et al. 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