{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:43:17Z","timestamp":1789720997757,"version":"4.0.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,10,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Neointimal hyperplasia after PTCA is an important component of restenosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Cultures of rabbit endothelial cells and smooth muscle cells (SMCs) were irradiated with different doses of nonablative infrared (1064-nm) radiation. Normalized viability index detected with nondestructive Alamar Blue assay and direct cell count were studied. Our experiments demonstrated dose-dependent cytostatic or cytotoxic effects of laser irradiation. We also evaluated the long-term effect of endoluminal nonablative infrared laser irradiation on neointimal hyperplasia in a rabbit balloon injury model. PTCA of both iliac arteries of 23 New Zealand White rabbits was performed. One iliac artery was subjected to intra-arterial subablative infrared irradiation via a diffuse tip fiber. The contralateral vessel served as control. The diet was supplemented with 0.25% cholesterol and 2% peanut oil for 10 days before and 60 days after PTCA. Morphometry after 60 days showed that intimal areas were 0.76\u00b10.18 and 1.85\u00b10.30 mm\n            <jats:sup>2<\/jats:sup>\n            in the laser and control arteries, respectively (\n            <jats:italic>P<\/jats:italic>\n            =2.2\u00d710\n            <jats:sup>\u221211<\/jats:sup>\n            ).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            We conclude that nonablative infrared laser inhibited neointimal hyperplasia after PTCA in cholesterol-fed rabbits for up to 60 days.\n          <\/jats:p>","DOI":"10.1161\/hc3901.096101","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"1850-1855","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Effect of Short Pulsed Nonablative Infrared Laser Irradiation on Vascular Cells In Vitro and Neointimal Hyperplasia in a Rabbit Balloon Injury Model"],"prefix":"10.1161","volume":"104","author":[{"given":"Nicholas","family":"Kipshidze","sequence":"first","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Nikolaychik","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Muckerheidi","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Keelan","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Chekanov","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Maternowski","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramjit","family":"Chawla","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Hernandez","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Iyer","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Sahota","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Roubin","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. Muckerheidi), and Medical College of Wisconsin, Milwaukee (M.H.K., P.C.), Wis; and Good Samaritan Hospital, Los Angeles, Calif (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Moses","sequence":"additional","affiliation":[{"name":"From Lenox Hill Heart and Vascular Institute of New York and Cardiovascular Research Foundation, New York, NY (N.K., S.I., G.D., M.B.L., G.R., J.W.M.); Milwaukee Heart Institute, Milwaukee (V.N., V.C., M. Maternowski, I.H.), Alien Technologies, Port Washington (M. 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