{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:49:17Z","timestamp":1773694157489,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,10,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            The peripheral and central chemoreflexes are important autonomic mechanisms for regulating breathing and cardiovascular function. Although pathological inflammatory infiltration of the peripheral chemoreceptors and central nervous system has been reported in Chagas\u2019 disease, functional evaluation of chemoreflexes has not yet been performed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            The hypothesis that chemoreflex function is altered in patients with Chagas\u2019 heart disease (CH) but normal left ventricle function was tested in 12 CH patients and 13 matched control subjects. The ventilatory rate, minute ventilation, heart rate, mean arterial pressure, forearm blood flow, forearm vascular resistance, and venous norepi-nephrine responses to hypoxia and hypercapnia were determined. During hypoxia, the decrease in oxygen saturation was smaller in CH patients, despite a similar ventilatory response between groups. Both groups showed an increase in heart rate during hypoxia, but this response was blunted in CH patients. Although the mean arterial pressure response to hypoxia was similar in both groups, forearm vascular resistance significantly decreased in control subjects while remaining unchanged in CH patients. Moreover, a significant increase in plasma norepinephrine levels elicited by stimulation of peripheral chemoreceptors was observed only in the CH group. During hypercapnia, the increase in minute ventilation was smaller in CH patients, who did not exhibit the increase in norepinephrine observed in control subjects.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            These data suggest that CH potentiates respiratory, cardiovascular, and autonomic responses to peripheral chemoreceptor activation by hypoxia in patients with normal left ventricular function. The ventilatory and sympathetic responses to central chemoreceptor activation by hypercapnia, however, are significantly blunted.\n          <\/jats:p>","DOI":"10.1161\/hc4001.097039","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"1792-1798","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Dysregulation of Peripheral and Central Chemoreflex Responses in Chagas\u2019 Heart Disease Patients Without Heart Failure"],"prefix":"10.1161","volume":"104","author":[{"given":"Jose\u0301 Augusto","family":"Soares Barreto-Filho","sequence":"first","affiliation":[{"name":"From the Hypertension Unit, Heart Institute, InCor, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Marciano","family":"Consolim-Colombo","sequence":"additional","affiliation":[{"name":"From the Hypertension Unit, Heart Institute, InCor, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heno","family":"Ferreira Lopes","sequence":"additional","affiliation":[{"name":"From the Hypertension Unit, Heart Institute, InCor, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Roberto","family":"Martins Sobrinho","sequence":"additional","affiliation":[{"name":"From the Hypertension Unit, Heart Institute, InCor, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia M.","family":"Guerra-Riccio","sequence":"additional","affiliation":[{"name":"From the Hypertension Unit, Heart Institute, InCor, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Moacyr","family":"Krieger","sequence":"additional","affiliation":[{"name":"From the Hypertension Unit, Heart Institute, InCor, University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60472-8"},{"key":"e_1_3_2_2_2","first-page":"281","volume":"8","year":"1966","unstructured":"Brand\u00e3o HJS, Zulian R. 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