{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:22:23Z","timestamp":1791292943577,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,10,16]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Recent studies demonstrated an influence of atherosclerotic risk factors on the progression of aortic valve stenosis. The extent of aortic valve calcification (AVC) was also found to be a strong predictor of stenosis progression. We investigated the influence of the LDL cholesterol level (LDL), other standard cardiovascular risk factors, and the extent of coronary calcification (CC) on the progression of AVC quantified by electron beam tomography (EBT).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            In 104 patients (64.7\u00b18 years, 89 male) with an EBT scan positive for AVC, CC and AVC were quantified using a volumetric score. EBT was repeated at a mean interval of 15 months (10 to 36 months), and the progression of AVC and CC was determined. Patients were divided into 2 groups according to LDL: group 1, LDL\u22643.36 mmol\/L (130 mg\/dL), 57 patients; group 2, LDL&gt;3.36 mmol\/L (130 mg\/dL), 47 patients. Mean values for CC were 546\u00b1932 mm\n            <jats:sup>3<\/jats:sup>\n            in scan 1 and 665\u00b11085 mm\n            <jats:sup>3<\/jats:sup>\n            in scan 2 for AVC 324\u00b1796 mm\n            <jats:sup>3<\/jats:sup>\n            and 404\u00b11076 mm\n            <jats:sup>3<\/jats:sup>\n            , respectively. The mean progression of CC was 27\u00b137% (group 1, 16\u00b122%; group 2, 39\u00b146%,\n            <jats:italic>P<\/jats:italic>\n            \u22640.001) and of AVC was 25\u00b138% (group 1, 9\u00b122%; group 2, 43\u00b144%,\n            <jats:italic>P<\/jats:italic>\n            \u22640.001).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Quantification of AVC by EBT permits new insights into the progression of aortic valve sclerosis. We observed a strong influence of LDL cholesterol level on the progression of AVC and CC, suggesting that lipid-lowering therapy may decrease the progression of aortic valve calcification.\n          <\/jats:p>","DOI":"10.1161\/hc4101.097527","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"1927-1932","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":319,"title":["Progression of Aortic Valve Calcification"],"prefix":"10.1161","volume":"104","author":[{"given":"Karsten","family":"Pohle","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Ma\u0308ffert","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Ropers","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Moshage","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaos","family":"Stilianakis","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner G.","family":"Daniel","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Achenbach","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine II (K.P., R.M., D.R. W.M., W.G.D., S.A.) and Department of Medical Information, Biometry, and Epidemiology (N.S.), University of Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00563-3"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2262"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060602"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.454000.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(05)80024-9"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1076-7460.2001.00839.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(96)90440-8"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.6.1715"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.2.7519131"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008313430903"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.2.211"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410302"},{"key":"e_1_3_1_13_2","unstructured":"Gould RG. Principles of ultrafast computed tomography: historical aspects mechanism and scanner characteristics.In: Stanford W Rumberger JA eds. Ultrafast Computed Tomography in Cardiac Imaging: Principles and Practice. Mt Kisco NY: Futura; 1993: 1\u201316."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.1979.4330523"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.8.2157"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.1.126"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812313392703"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01392-8"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00820-1"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.218.1.r01ja34224"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/204748730000700203"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90818-6"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/21\/3\/306"},{"key":"e_1_3_1_25_2","first-page":"361","volume":"10","year":"2001","unstructured":"Kizer JR, Gefter WB, de Lemos AS, et al. Electron beam computed tomography for the quantification of aortic valve calcification. J Heart Valve Dis. 2001; 10: 361\u2013366.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.3.9722864"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)81191-1"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02572-1"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.21.2497"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.19.5.1218"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(00)00043-0"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00389-2"},{"key":"e_1_3_1_33_2","first-page":"269","volume":"26","year":"1996","unstructured":"Fuster V, Badimon J, Chesebro JH, et al. Plaque rupture, thrombosis, and therapeutic implications. Haemostasis. 1996; 26: 269\u2013284.","journal-title":"Haemostasis"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.16.8.1070"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.3.8058924"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hc4101.097527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:20:55Z","timestamp":1738830055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hc4101.097527"}},"subtitle":["Association With Coronary Atherosclerosis and Cardiovascular Risk Factors"],"short-title":[],"issued":{"date-parts":[[2001,10,16]]},"references-count":35,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2001,10,16]]}},"alternative-id":["10.1161\/hc4101.097527"],"URL":"https:\/\/doi.org\/10.1161\/hc4101.097527","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,16]]},"assertion":[{"value":"2001-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}