{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:39:16Z","timestamp":1782293956052,"version":"3.54.5"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,10,30]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Radioactive stents have been reported to reduce in-stent neointimal thickening. An unexpected increase in neointimal response was observed, however, at the stent-to-artery transitions, the so-called \u201cedge effect.\u201d To investigate the factors involved in this edge effect, we studied stents with 1 radioactive half and 1 regular nonradioactive half, thereby creating a midstent radioactive dose-falloff zone next to a nonradioactive stent-artery transition at one side and a radioactive stent-artery transition at the other side.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Half-radioactive stents (n=20) and nonradioactive control stents (n=10) were implanted in the coronary arteries of Yucatan micropigs. Animals received aspirin and clopidogrel as antithrombotics. After 4 weeks, a significant midstent stenosis was observed by angiography in the half-radioactive stents. Two animals died suddenly because of coronary occlusion at this mid zone at 8 and 10 weeks. At 12-week follow-up angiography, intravascular ultrasound and histomorphometry showed a significant neointimal thickening at the midstent dose-falloff zone of the half-radioactive stents, but not at the stent-to-artery transitions at both extremities. Such a midstent response (mean angiographic late loss 1.0 mm) was not observed in the nonradioactive stents (mean loss 0.4 to 0.6 mm;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            The edge effect of high-dose radioactive stents in porcine coronary arteries is associated with the combination of stent injury and radioactive dose falloff.\n          <\/jats:p>","DOI":"10.1161\/hc4301.097873","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"2236-2241","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["\u201cEdge Effect\u201d of\n            <sup>32<\/sup>\n            P Radioactive Stents Is Caused by the Combination of Chronic Stent Injury and Radioactive Dose Falloff"],"prefix":"10.1161","volume":"104","author":[{"given":"Willem J.","family":"van der Giessen","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Regar","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda S.","family":"Harteveld","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique L.M.A.","family":"Coen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Bhagwandien","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Au","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Levendag","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Ligthart","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad","family":"den Boer","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter D.","family":"Verdouw","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; and Guidant Inc, Santa Clara, Calif (A.A., T.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Hu","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Thoraxcenter (W.J.v.d.G., E.R., M.S.H., R.B., J.L., P.W.S., A.d.B., P.D.V., E.B., H.M.M.v.B.), and Department of Radiation Oncology, Erasmus Medical Center (V.L.M.A.C., P.C.L.), Rotterdam, the Netherlands; 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