{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:17:21Z","timestamp":1780064241563,"version":"3.54.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,11,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Balloon-expandable \u03b2-particle\u2013emitting (\n            <jats:sup>32<\/jats:sup>\n            P) stents inhibit within-stent neointimal hyperplasia but induce lumen narrowing beyond the stent margins, ie, the so-called \u201cedge effects.\u201d\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            We prospectively investigated the performance of novel stents impregnated with the \u03b3-emitting isotope\n            <jats:sup>103<\/jats:sup>\n            Pd, designed to reduce edge effects, in 24 rabbits. The stents had a length of 18 mm and were mounted on 20-mm-long delivery balloons for deployment. Angiograms were obtained immediately and 1 month after direct implantation of control and 1-, 2-, and 4-mCi\n            <jats:sup>103<\/jats:sup>\n            Pd stents into the iliac arteries without predilatation or postdilatation. Late lumen loss was measured with quantitative angiography. Neointimal hyperplasia and vascular remodeling were evaluated by histomorphometry. Late lumen loss was inhibited within\n            <jats:sup>103<\/jats:sup>\n            Pd stents (control 0.18 mm, 1 mCi 0.08 mm, 2 mCi 0.05 mm, and 4 mCi \u22120.03 mm,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 all activities versus control). Conversely, late lumen loss occurred at the edges of\n            <jats:sup>103<\/jats:sup>\n            Pd stents, correlating with areas of high balloon\/artery ratios and vessel overstretch injury. Edge effects were primarily due to neointimal hyperplasia but were also caused by negative vessel remodeling at high stent activities.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Edge effects after implantation of radioisotope stents can occur independently of the isotope chosen for stent impregnation.\n          <\/jats:p>","DOI":"10.1161\/hc4401.098469","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"2358-2362","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Failure of a Novel Balloon-Expandable \u03b3-Emitting (\n            <sup>103<\/sup>\n            Pd) Stent to Prevent Edge Effects"],"prefix":"10.1161","volume":"104","author":[{"given":"Christoph","family":"Hehrlein","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"DeVries","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Arab","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Haller","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schloesser","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferman O.","family":"Tio","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Fischell","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.6.2956"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1570"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.4.641"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.16.1684"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.1.18"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.21.2454"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.102.13.1484"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.101.21.2467"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00415-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8043(98)00180-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.3.529"},{"key":"e_1_3_2_13_2","first-page":"327","volume":"1","year":"2000","unstructured":"Carter AJ, Jenkins S, Sweet W, et al. Dose and dose rate effects of beta-particle emitting radioactive stents in a porcine model of restenosis. Cardiovasc Radiat Med. 2000; 1: 327\u2013335.","journal-title":"Cardiovasc Radiat Med"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hc4401.098469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:35:56Z","timestamp":1715650556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hc4401.098469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,6]]},"references-count":13,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2001,11,6]]}},"alternative-id":["10.1161\/hc4401.098469"],"URL":"https:\/\/doi.org\/10.1161\/hc4401.098469","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11,6]]},"assertion":[{"value":"2001-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}