{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:46:25Z","timestamp":1790012785480,"version":"4.0.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,11,27]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            The Post Coronary Artery Bypass Graft Trial, designed to compare the effects of two lipid-lowering regimens and low-dose anticoagulation versus placebo on progression of atherosclerosis in saphenous vein grafts of patients who had had CABG surgery, demonstrated that aggressive lowering of LDL cholesterol levels to a mean yearly cholesterol level from 93 to 97 mg\/dL compared with a moderate reduction to a level of 132 to 136 mg\/dL decreased the progression of atherosclerosis in saphenous vein grafts. Low-dose anticoagulation did not affect progression. This secondary analysis tested the hypothesis that a similar decrease in progression of atherosclerosis would also be present in native coronary arteries as measured in the left main coronary artery (LMCA).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            A sample of 402 patients was randomly selected from 1102 patients who had baseline and follow-up views of the LMCA suitable for analysis. Patients treated with the aggressive lipid-lowering strategy had less progression of atherosclerosis in the LMCA as measured by changes in minimum (\n            <jats:italic>P<\/jats:italic>\n            =0.0003) lumen diameter or the maximum percent stenosis (\n            <jats:italic>P<\/jats:italic>\n            =0.001), or the presence of substantial progression (\n            <jats:italic>P<\/jats:italic>\n            =0.008), or vascular occlusion (\n            <jats:italic>P<\/jats:italic>\n            =0.005) when compared with the moderate strategy.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            A strategy of aggressive lipid lowering results in significantly less atherosclerosis progression than a moderate approach in LMCAs.\n          <\/jats:p>","DOI":"10.1161\/hc4701.099730","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"2660-2665","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Effect of an Aggressive Lipid-Lowering Strategy on Progression of Atherosclerosis in the Left Main Coronary Artery From Patients in the Post Coronary Artery Bypass Graft Trial"],"prefix":"10.1161","volume":"104","author":[{"given":"Carl W.","family":"White","sequence":"first","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredarick L.","family":"Gobel","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Campeau","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genell L.","family":"Knatterud","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Forman","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Forrester","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Geller","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alan","family":"Herd","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hickey","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron J.","family":"Hoogwerf","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Hunninghake","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Terrin","sequence":"additional","affiliation":[{"name":"From the University of Minnesota, Minneapolis (C.W.W., D.B.H.); Minneapolis Heart Institute Foundation, Minneapolis, Minn (F.L.G.); Montreal Heart Institute, Montreal, Quebec, Canada (L.C.); Maryland Medical Research Institute, Baltimore, Md (G.L.K., S.A.F., M.L.T.); Cedars-Sinai Medical Center, Los Angeles, Calif (J.S.F., A.H.); Baylor College of Medicine, Houston, Tex (J.A.H.); Cleveland Clinic Foundation, Cleveland, Ohio (B.J.H.); Office of Biostatistics Research, National Heart, Lung, and Blood..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Post Coronary Artery Bypass Graft Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701163360301"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.25.3241"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.6.1289"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80810-8"},{"key":"e_1_3_3_5_2","first-page":"70","volume":"34","year":"1999","unstructured":"Pitt B, Waters D, Brown WV, et al. 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