{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:27:47Z","timestamp":1793831267949,"version":"4.6.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"25","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation"],"published-print":{"date-parts":[[2001,12,17]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                  \u2014\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Coronary endothelial dysfunction may be an early marker for cardiac allograft vasculopathy (CAV) in orthotopic heart transplant recipients. Using serial studies with intravascular ultrasound and Doppler flow-wire measurements, we have previously demonstrated that annual decrements in coronary endothelial function are associated with progressive intimal thickening. The present study tested whether endothelial dysfunction predicts subsequent clinical events, including cardiac death and CAV development.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results<\/jats:italic>\n                  \u2014\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Seventy-three patients were studied yearly beginning at transplantation until a prespecified end point was reached. End points were angiographic evidence of CAV (&gt;50% stenosis) or cardiac death (graft failure or sudden death). At each study, coronary endothelial function was measured with intracoronary infusions of adenosine (32-\u03bcg bolus), acetylcholine (54 \u03bcg over 2 minutes), and nitroglycerin (200 \u03bcg) into the left anterior descending coronary artery; intravascular ultrasound images and Doppler velocities were recorded simultaneously. Of the 73 patients studied, 14 reached an end point during the study (6 CAV and 8 deaths, including 4 with known CAV, 1 graft failure, and 3 sudden). On the last study performed, the group with an end point had decreased epicardial (constriction of 11.1\u00b12.9% versus dilation of 1.7\u00b12.2%,\n            <jats:italic>P<\/jats:italic>\n            =0.01) and microvascular (flow increase of 75\u00b120% versus 149\u00b116%,\n            <jats:italic>P<\/jats:italic>\n            =0.03) endothelium-dependent responses to acetylcholine compared with the patients who did not reach an end point. Responses to adenosine and nitroglycerin did not differ significantly.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                  \u2014\n                <\/jats:bold>\n              <\/jats:italic>\n            <\/jats:bold>\n            Endothelial dysfunction, as detected by abnormal responses to acetylcholine, preceded the development of clinical end points. These data implicate endothelial dysfunction in the development of clinically significant vasculopathy and suggest that serial studies of endothelial function have clinical utility.\n          <\/jats:p>","DOI":"10.1161\/hc5001.100796","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T18:31:09Z","timestamp":1191004269000},"page":"3091-3096","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":147,"title":["Coronary Endothelial Dysfunction After Heart Transplantation Predicts Allograft Vasculopathy and Cardiac Death"],"prefix":"10.1161","volume":"104","author":[{"given":"Steven M.","family":"Hollenberg","sequence":"first","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd W.","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Parrillo","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Scherer","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durand","family":"Burns","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tamburro","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Oberoi","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryl R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosa","family":"Costanzo","sequence":"additional","affiliation":[{"name":"From the Section of Cardiology, Rush-Presbyterian-St Luke\u2019s Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00037-6"},{"key":"e_1_3_2_2_2","first-page":"S69","volume":"11","year":"1992","unstructured":"Yeung AC, Anderson T, Meredith I, et al. Endothelial dysfunction in the development and detection of transplant coronary artery disease. J Heart Lung Transplant. 1992; 11: S69\u2013S73.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.6.2069"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.5.458"},{"key":"e_1_3_2_5_2","first-page":"744","volume":"17","year":"1998","unstructured":"Costanzo MR, Naftel DC, Pritzker MR, et al. Heart transplant coronary artery disease detected by coronary angiography: a multi-institutional study of preoperative donor and recipient risk factors: Cardiac Transplant Research Database. J Heart Lung Transplant. 1998; 17: 744\u2013753.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_6_2","first-page":"S215","volume":"14","year":"1995","unstructured":"Yeung AC, Davis SF, Hauptman PJ, et al. Incidence and progression of transplant coronary artery disease over 1 year: results of a multicenter trial with use of intravascular ultrasound: Multicenter Intravascular Ultrasound Transplant Study Group. J Heart Lung Transplant. 1995; 14: S215\u2013S220.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_7_2","first-page":"487","volume":"17","year":"1998","unstructured":"Hollenberg SM, Tamburro P, Klein LW, et al. Discordant epicardial and microvascular endothelial responses in heart transplant recipients early after transplantation. J Heart Lung Transplant. 1998; 17: 487\u2013494.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(199903)46:3<282::AID-CCD5>3.0.CO;2-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.82.5.2225364"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113297"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.4.1171"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.4.1394923"},{"key":"e_1_3_2_13_2","first-page":"S198","volume":"14","year":"1995","unstructured":"Johnson JA, Kobashigawa JA. Quantitative analysis of transplant coronary artery disease with use of intracoronary ultrasound. J Heart Lung Transplant. 1995; 14: S198\u2013S202.","journal-title":"J Heart Lung Transplant"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.5.1899"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00357-6"},{"key":"e_1_3_2_16_2","first-page":"871","volume":"137","year":"1990","unstructured":"Hruban RH, Beschorner WE, Baumgartner WA, et al. Accelerated arteriosclerosis in heart transplant recipients is associated with T-lymphocyte-mediated endothelial endothelialitis. Am J Pathol. 1990; 137: 871\u2013882.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(97)80030-8"},{"key":"e_1_3_2_18_2","first-page":"I-391.","volume":"100","year":"1999","unstructured":"Hollenberg SM, Scherer MD, Wurzburg DD, et al. Changes in coronary endothelial function predict progression of allograft vasculopathy late after heart transplantation. Circulation. 1999; 100 (suppl I): I-391.Abstract.","journal-title":"Circulation"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.90.5.7955193"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200003150-00030"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198610233151702"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4651"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.4.1062"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.85.8.753"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00142-M"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00128-X"}],"container-title":["Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/hc5001.100796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T02:13:01Z","timestamp":1715652781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/hc5001.100796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,17]]},"references-count":27,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2001,12,17]]}},"alternative-id":["10.1161\/hc5001.100796"],"URL":"https:\/\/doi.org\/10.1161\/hc5001.100796","relation":{},"ISSN":["0009-7322","1524-4539"],"issn-type":[{"value":"0009-7322","type":"print"},{"value":"1524-4539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,17]]},"assertion":[{"value":"2001-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}