{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:36:42Z","timestamp":1789616202286,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2002,3,8]]},"abstract":"<jats:p>\n            A central role for leukocytes in neointimal hyperplasia after arterial injury is suspected. However, the relative importance of neutrophils and monocytes in balloon or stent-induced injury are not well understood, and mechanistic targeting of leukocyte recruitment or function is crude. We determined the temporal and spatial distribution of different leukocytes after balloon and stent-induced injury in primate iliac arteries. Based on these data, we targeted neutrophil and monocyte recruitment selectively after angioplasty or stent implantation and demonstrated that monocyte-specific blockade achieved via blockade of the MCP-1 receptor CCR2, was effective at reducing neointimal hyperplasia after stenting. In contrast, combined neutrophil and monocyte blockade achieved by targeting the leukocyte \u03b2\n            <jats:sub>2<\/jats:sub>\n            -integrin \u03b2-subunit CD18 was required to reduce neointimal hyperplasia after balloon injury. Distinct patterns of leukocyte infiltration in balloon versus stent-injured arteries predict distinct mechanisms for antiinflammatory strategies targeting neutrophils or monocytes in primates and may assist design of effective clinical strategies for optimizing vascular interventions.\n          <\/jats:p>","DOI":"10.1161\/hh0402.105956","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Targeting CCR2 or CD18 Inhibits Experimental In-Stent Restenosis in Primates"],"prefix":"10.1161","volume":"90","author":[{"given":"Christopher","family":"Horvath","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass and the Harvard\/MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass (F.G.P.W., C.R.); the West Roxbury Veteran\u2019s Affairs Medical Center (F.G.P.W.), West Roxbury, Mass; and the Clinical Investigator Training Program, Harvard\/MIT Division of Health Sciences and Technology-Beth Israel Deaconess..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick G.P.","family":"Welt","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass and the Harvard\/MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass (F.G.P.W., C.R.); the West Roxbury Veteran\u2019s Affairs Medical Center (F.G.P.W.), West Roxbury, Mass; and the Clinical Investigator Training Program, Harvard\/MIT Division of Health Sciences and Technology-Beth Israel Deaconess..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nedelman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass and the Harvard\/MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass (F.G.P.W., C.R.); the West Roxbury Veteran\u2019s Affairs Medical Center (F.G.P.W.), West Roxbury, Mass; and the Clinical Investigator Training Program, Harvard\/MIT Division of Health Sciences and Technology-Beth Israel Deaconess..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Rao","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass and the Harvard\/MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass (F.G.P.W., C.R.); the West Roxbury Veteran\u2019s Affairs Medical Center (F.G.P.W.), West Roxbury, Mass; and the Clinical Investigator Training Program, Harvard\/MIT Division of Health Sciences and Technology-Beth Israel Deaconess..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbell","family":"Rogers","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Cardiac Catheterization Laboratory, Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Mass and the Harvard\/MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Mass (F.G.P.W., C.R.); the West Roxbury Veteran\u2019s Affairs Medical Center (F.G.P.W.), West Roxbury, Mass; and the Clinical Investigator Training Program, Harvard\/MIT Division of Health Sciences and Technology-Beth Israel Deaconess..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10134"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.20.12.2553"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90609-Q"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01605979"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.16.10.1312"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90476-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198602203140806"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.12.3098"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00563-3"},{"key":"e_1_3_3_10_2","first-page":"I-370.","volume":"88","year":"1993","unstructured":"Rogers C, Karnovsky MJ, Edelman ER. 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